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Andrew D. Ellington
Researcher at University of Texas at Austin
Publications - 599
Citations - 48723
Andrew D. Ellington is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: Aptamer & RNA. The author has an hindex of 96, co-authored 569 publications receiving 43262 citations. Previous affiliations of Andrew D. Ellington include Harvard University & UPRRP College of Natural Sciences.
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Kinetic optimization of a protein-responsive aptamer beacon
TL;DR: Comparisons across multiple, designed aptamer beacons indicate that there is a strong inverse correlation between the thermodynamics of hybridization and the speed of activation, a finding that should prove to be generally useful in the design of future biosensors.
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Toward automated nucleic acid enzyme selection.
Letha J. Sooter,Timothy E. Riedel,Eric A. Davidson,Matthew Levy,J. C. Cox,Andrew D. Ellington +5 more
TL;DR: Difficulties were encountered during the automation of DNA catalyst selection, including effectively washing beadbound DNA, pipetting 50% glycerol solutions, purifying single strand DNA, and monitoring the progress of the selection as it is performed.
Journal ArticleDOI
Free energy differences between enzyme bound states.
TL;DR: The controversy over the kinetically optimal free energy profile for an enzymatic reaction operating under constraints set forward by Albery & Knowles (1976) is resolved.