Andrew D. Ellington

TL;DR: A number of aptamers against therapeutically important targets have shown efficacy in cell and animal models, and a handful are now in clinical trials or are being used as drugs.

TL;DR: The in vitro selection of nucleic acid binding species (aptamers) is frequently repetitive, time-consuming, and poorly adapted to high-throughput applications as discussed by the authors ; however, the increases in throughput brought about by automation should potentiate the application of aptamer technology to the rapidly growing field of proteomics.

TL;DR: This review seeks to provide an overview of the current thinking on molecular profiling for diagnosis and prognosis of cancers and provide insight into the current state-of-the-art in the biosensor field and new strategies that must be considered to bring this important technology into the cancer field.

TL;DR: It is found that the V-gene repertoire of BMPCs becomes highly polarized after immunization, with the most abundant sequences represented at frequencies between ∼1% and >10% of the total repertoire.

TL;DR: Upon nutrient depletion the authors observe widespread protein assemblies displaying nutrient-specific formation and dissolution, and a surprising number of proteins involved in intermediary metabolism and stress response were observed to form punctate cytoplasmic foci.