A
Arun Padmanabhan
Researcher at University of California, San Francisco
Publications - 41
Citations - 2362
Arun Padmanabhan is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Medicine & Transcription factor. The author has an hindex of 13, co-authored 29 publications receiving 1894 citations. Previous affiliations of Arun Padmanabhan include Miami University & Harvard University.
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Journal ArticleDOI
Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS
Andrew Elden,Hyung-Jun Kim,Michael P. Hart,Alice Chen-Plotkin,Brian S. Johnson,Xiaodong Fang,Maria Armakola,Felix Geser,Robert W. Greene,Min Min Lu,Arun Padmanabhan,Dana Clay-Falcone,Leo McCluskey,Lauren Elman,Denise Juhr,Peter J. Gruber,Udo Rüb,Georg Auburger,John Q. Trojanowski,Virginia M.-Y. Lee,Vivianna M. Van Deerlin,Nancy M. Bonini,Aaron D. Gitler +22 more
TL;DR: It is shown that ataxin 2 (ATXN2), a polyglutamine (polyQ) protein mutated in spinocerebellar ataxia type 2, is a potent modifier of TDP-43 toxicity in animal and cellular models.
Journal ArticleDOI
Plasticity of Hopx + type I alveolar cells to regenerate type II cells in the lung
Rajan Jain,Christina E. Barkauskas,Norifumi Takeda,Emily Bowie,Haig Aghajanian,Qiaohong Wang,Arun Padmanabhan,Lauren J. Manderfield,Mudit Gupta,Deqiang Li,Li Li,Chinmay M. Trivedi,Brigid L.M. Hogan,Jonathan A. Epstein +13 more
TL;DR: It is shown that Hopx becomes restricted to Type I cells during development and, unexpectedly, lineage-labeled Hopx+ cells both proliferate and generate Type II cells during adult alveolar regrowth following partial pneumonectomy.
Journal ArticleDOI
Rapid 3D Phenotyping of Cardiovascular Development in Mouse Embryos by Micro-CT With Iodine Staining
TL;DR: It is shown how multiple cardiac defects can be demonstrated by micro-CT in a single specimen with a known genetic lesion, and a previously undescribed cardiac venous abnormality is revealed in a PlexinD1 mutant mouse.
Journal ArticleDOI
Integration of Bmp and Wnt signaling by Hopx specifies commitment of cardiomyoblasts
Rajan Jain,Deqiang Li,Mudit Gupta,Lauren J. Manderfield,Jamie L. Ifkovits,Qiaohong Wang,Feiyan Liu,Ying Liu,Andrey Poleshko,Arun Padmanabhan,Jeffrey C. Raum,Li Li,Edward E. Morrisey,Min Min Lu,Kyoung-Jae Won,Jonathan A. Epstein +15 more
TL;DR: A specialized progenitor population that is committed exclusively to forming cardiomyocytes is identified and the mechanisms governing commitment to the myocyte lineage in vivo are identified, suggesting that Hopx promotes myogenesis by repressing Wnt signaling.
Journal ArticleDOI
Evaluation and application of modularly assembled zinc-finger nucleases in zebrafish.
Cong Zhu,Tom Smith,Joseph C. McNulty,Amy L. Rayla,Abirami Lakshmanan,Arndt F. Siekmann,Matthew Buffardi,Xiangdong Meng,Jimann Shin,Arun Padmanabhan,Daniel Cifuentes,Antonio J. Giraldez,A. Thomas Look,Jonathan A. Epstein,Nathan D. Lawson,Scot A. Wolfe +15 more
TL;DR: This work generates new germline mutations in eight different genes, confirming that this is a viable platform for heritable gene inactivation in vertebrates and highlights the benefit of a definitive reverse genetic strategy to reveal gene function.