K
Khai Koon Heng
Researcher at Genome Institute of Singapore
Publications - 3
Citations - 811
Khai Koon Heng is an academic researcher from Genome Institute of Singapore. The author has contributed to research in topics: Genome-wide association study & SNP array. The author has an hindex of 3, co-authored 3 publications receiving 683 citations.
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Journal ArticleDOI
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis
Steve Eyre,John Bowes,John Bowes,Dorothée Diogo,Dorothée Diogo,Annette Lee,Anne Barton,Anne Barton,Paul Martin,Paul Martin,Alexandra Zhernakova,Alexandra Zhernakova,Eli A. Stahl,Eli A. Stahl,Sebastien Viatte,Sebastien Viatte,Kate McAllister,Kate McAllister,Christopher I. Amos,Leonid Padyukov,René E. M. Toes,Tom W J Huizinga,Cisca Wijmenga,Gosia Trynka,Lude Franke,Harm-Jan Westra,Lars Alfredsson,Xinli Hu,Cynthia Sandor,Cynthia Sandor,Paul I.W. de Bakker,Sonia Davila,Chiea Chuen Khor,Khai Koon Heng,Robert Andrews,Sarah Edkins,Sarah E. Hunt,Cordelia Langford,Deborah P M Symmons,Deborah P M Symmons,Genomics Study Syndicate,Patrick Concannon,Suna Onengut-Gumuscu,Stephen S. Rich,Panos Deloukas,Miguel A. Gonzalez-Gay,Luis Rodriguez-Rodriguez,Lisbeth Ärlsetig,Javier Martin,Solbritt Rantapää-Dahlqvist,Robert M. Plenge,Robert M. Plenge,Soumya Raychaudhuri,Lars Klareskog,Peter K. Gregersen,Jane Worthington,Jane Worthington +56 more
TL;DR: This study illustrates the advantages of dense SNP mapping analysis to inform subsequent functional investigations and refined the peak of association to a single gene for 19 loci, identified secondary independent effects at 6 loci and identified association to low-frequency variants at 4 loci.
Journal ArticleDOI
Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci
Tin Aung,Tin Aung,Mineo Ozaki,Mei Chin Lee,Ursula Schlötzer-Schrehardt,Gudmar Thorleifsson,Takanori Mizoguchi,Robert P. Igo,Aravind Haripriya,Susan Williams,Yury S. Astakhov,Andrew C. Orr,Kathryn P. Burdon,Kathryn P. Burdon,Satoko Nakano,Kazuhiko Mori,Khaled K. Abu-Amero,Khaled K. Abu-Amero,Michael A. Hauser,Zheng Li,Gopalakrishnan Prakadeeswari,Jessica N. Cooke Bailey,Alina Popa Cherecheanu,Jae H. Kang,Sarah C. Nelson,Ken Hayashi,Shin-ichi Manabe,Shigeyasu Kazama,Tomasz Zarnowski,Kenji Inoue,Murat Irkec,Miguel Coca-Prados,Miguel Coca-Prados,Kazuhisa Sugiyama,Irma Järvelä,Patricio G. Schlottmann,S Fabian Lerner,Hasnaa Lamari,Yildirim Nilgün,Mukharram M. Bikbov,Ki Ho Park,Soon Cheol Cha,Kenji Yamashiro,Juan Carlos Zenteno,Jost B. Jonas,Jost B. Jonas,Rajesh Kumar,Shamira A. Perera,Anita S Y Chan,Anita S Y Chan,Nino Kobakhidze,Ronnie George,Lingam Vijaya,Tan Do,Deepak P. Edward,Lourdes de Juan Marcos,Mohammad Pakravan,Sasan Moghimi,Ryuichi Ideta,Daniella Bach-Holm,Per Kappelgaard,Barbara M Wirostko,Scott Thomas,Daniel Gaston,Karen Bedard,Wenda L. Greer,Zhenglin Yang,Xueyi Chen,Lulin Huang,Lulin Huang,Jinghong Sang,Hongyan Jia,Liyun Jia,Chunyan Qiao,Hui Zhang,Xuyang Liu,Bowen Zhao,Ya Xing Wang,Liang Xu,Stéphanie Leruez,Pascal Reynier,George Chichua,Sergo Tabagari,Steffen Uebe,Matthias Zenkel,Daniel Berner,Georg Mossböck,Nicole Weisschuh,Ursula Hoja,Ulrich-Christoph Welge-Luessen,Christian Y. Mardin,Panayiota Founti,Anthi Chatzikyriakidou,Theofanis Pappas,Eleftherios Anastasopoulos,Alexandros Lambropoulos,Arkasubhra Ghosh,Rohit Shetty,Natalia Porporato,Vijayan Saravanan,Rengaraj Venkatesh,Chandrashekaran Shivkumar,N Kalpana,Sripriya Sarangapani,Mozhgan Rezaei Kanavi,Afsaneh Naderi Beni,Shahin Yazdani,Alireza Lashay,Homa Naderifar,Nassim Khatibi,Antonio Maria Fea,Carlo Lavia,Laura Dallorto,Teresa Rolle,Paolo Frezzotti,Daniela Paoli,Erika Salvi,Paolo Manunta,Yosai Mori,Kazunori Miyata,Tomomi Higashide,Etsuo Chihara,Satoshi Ishiko,Akitoshi Yoshida,Masahide Yanagi,Yoshiaki Kiuchi,Tsutomu Ohashi,Toshiya Sakurai,Takako Sugimoto,Hideki Chuman,Makoto Aihara,Masaru Inatani,Masahiro Miyake,Norimoto Gotoh,Fumihiko Matsuda,Nagahisa Yoshimura,Yoko Ikeda,Morio Ueno,Chie Sotozono,Jin Wook Jeoung,Min Sagong,Kyu Hyung Park,Jeeyun Ahn,Marisa Cruz-Aguilar,Sidi M Ezzouhairi,Abderrahman Rafei,Yaan Fun Chong,Xiao Yu Ng,Shuang Ru Goh,Yueming Chen,Victor H. K. Yong,Muhammad Imran Khan,Olusola Olawoye,Olusola Olawoye,Adeyinka O. Ashaye,Adeyinka O. Ashaye,Idakwo Ugbede,Adeola O Onakoya,Adeola O Onakoya,Nkiru Kizor-Akaraiwe,Chaiwat Teekhasaenee,Yanin Suwan,Wasu Supakontanasan,Suhanya Okeke,Nkechi J Uche,Ifeoma N. Asimadu,Humaira Ayub,Farah Akhtar,Ewa Kosior-Jarecka,Urszula Lukasik,Ignacio Lischinsky,Vania Castro,Rodolfo Perez Grossmann,Gordana Sunaric Megevand,Sylvain Roy,Edward Dervan,Eoin Silke,Aparna Rao,Priti Sahay,Pablo Fornero,Osvaldo Cuello,Delia Sivori,Tamara Zompa,Richard A. Mills,Emmanuelle Souzeau,Paul Mitchell,Jie Jin Wang,Alex W. Hewitt,Alex W. Hewitt,Michael Coote,Jonathan G Crowston,Sergei Y. Astakhov,Eugeny L. Akopov,A. Emelyanov,A. Emelyanov,Vera Vysochinskaya,Gyulli M. Kazakbaeva,R.R. Fayzrakhmanov,Saleh A. Al-Obeidan,Ohoud Owaidhah,Leyla Al-Jasim,Balram Chowbay,Balram Chowbay,Jia Nee Foo,Jia Nee Foo,Raphael Q Soh,Kar Seng Sim,Z. Xie,Augustine W O Cheong,Shi Qi Mok,Hui Meng Soo,Xiao Yin Chen,Su Qin Peh,Khai Koon Heng,Rahat Husain,Su-Ling Ho,Axel M. Hillmer,Ching-Yu Cheng,Francisco A. Escudero-Domínguez,Rogelio González-Sarmiento,Frederico Martinon-Torres,Antonio Salas,Kessara Pathanapitoon,Linda Hansapinyo,Boonsong Wanichwecharugruang,Naris Kitnarong,Anavaj Sakuntabhai,Anavaj Sakuntabhai,Hip X Nguyn,Giang T T Nguyn,Trình V Nguyn,Werner Zenz,A. Binder,DS Klobassa,Martin L. Hibberd,Martin L. Hibberd,Sonia Davila,Stefan Herms,Stefan Herms,Stefan Herms,Markus M. Nöthen,Susanne Moebus,Robyn M. Rautenbach,Ari Ziskind,Trevor R. Carmichael,Michèle Ramsay,Lydia Álvarez,Montserrat García,Héctor González-Iglesias,Pedro Pablo Rodríguez-Calvo,Luis Fernández-Vega Cueto,Çilingir Oguz,Nevbahar Tamçelik,Eray Atalay,Bilge Batu,Dilek Aktas,Burcu Kasım,M. Roy Wilson,Anne L. Coleman,Yutao Liu,Pratap Challa,Leon W. Herndon,Rachel W. Kuchtey,John Kuchtey,Karen Curtin,Craig J. Chaya,Alan S. Crandall,Linda M. Zangwill,Tien Yin Wong,Tien Yin Wong,Masakazu Nakano,Shigeru Kinoshita,Anneke I. den Hollander,Eija Vesti,John H. Fingert,John H. Fingert,Richard K. Lee,Arthur J. Sit,Bradford J. Shingleton,Ningli Wang,Daniele Cusi,Raheel Qamar,Raheel Qamar,Peter Kraft,Margaret A. Pericak-Vance,Soumya Raychaudhuri,Steffen Heegaard,Tero Kivelä,André Reis,Friedrich E. Kruse,Robert N. Weinreb,Louis R. Pasquale,Louis R. Pasquale,Jonathan L. Haines,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Fridbert Jonasson,R. Rand Allingham,Dan Milea,Dan Milea,Robert Ritch,Toshiaki Kubota,Kei Tashiro,Eranga N. Vithana,Shazia Micheal,Fotis Topouzis,Jamie E Craig,Michael V. Dubina,Michael V. Dubina,Periasamy Sundaresan,Kari Stefansson,Kari Stefansson,Janey L. Wiggs,Francesca Pasutto,Chiea Chuen Khor,Chiea Chuen Khor +315 more
TL;DR: A rare protective allele at LOXL1 is identified through deep resequencing of XFS cases and controls and a potential role for naturally occurring rare LO XL1 variants in disease biology is highlighted.
Journal ArticleDOI
Genome-wide association study of Parkinson's disease in East Asians.
Jia Nee Foo,Jia Nee Foo,Louis C.S. Tan,Ishak D. Irwan,Wing Lok Au,Hui Qi Low,Kumar M. Prakash,Azlina Ahmad-Annuar,Jin-Xin Bei,Anne Y.Y. Chan,Chiung Mei Chen,Yi-Chun Chen,Sun Ju Chung,Hao Deng,Shen-Yang Lim,Vincent Mok,Hao Pang,Zhong Pei,Rong Peng,Hui-Fang Shang,Kyuyoung Song,Ai Huey Tan,Yih-Ru Wu,Tin Aung,Ching-Yu Cheng,Fook Tim Chew,Soo-Hong Chew,Siow Ann Chong,Richard P. Ebstein,Jimmy Lee,Seang-Mei Saw,Adeline Seow,Mythily Subramaniam,E-Shyong Tai,Eranga N. Vithana,Tien Yin Wong,Khai Koon Heng,Wee-Yang Meah,Chiea Chuen Khor,Chiea Chuen Khor,Hong Liu,Furen Zhang,Jianjun Liu,Eng-King Tan +43 more
TL;DR: This is the first Han Chinese GWAS analysing a total of 22,729 subjects from Singapore, Hong Kong, Malaysia, Korea, mainland China and Taiwan and observes strong associations reaching genome-wide significance at SNCA, LRRK2 and MCCC1, confirming their important roles in both European and Asian PD.