B
Balaraman Kalyanaraman
Researcher at Medical College of Wisconsin
Publications - 488
Citations - 42413
Balaraman Kalyanaraman is an academic researcher from Medical College of Wisconsin. The author has contributed to research in topics: Radical & Superoxide. The author has an hindex of 100, co-authored 475 publications receiving 38562 citations. Previous affiliations of Balaraman Kalyanaraman include University of Alabama at Birmingham & University of Alabama.
Papers
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Journal ArticleDOI
Superoxide generation by endothelial nitric oxide synthase: The influence of cofactors
Jeannette Vasquez-Vivar,Balaraman Kalyanaraman,Pavel Martásek,Neil Hogg,Bettie Sue Siler Masters,Hakim Karoui,Paul Tordo,Kirkwood A. Pritchard +7 more
TL;DR: The mechanism of superoxide generation by endothelial nitric oxide synthase (eNOS) was investigated by the electron spin resonance spin-trapping technique using 5-diethoxyphosphoryl-5-methyl-1-pyrroline N-oxide as discussed by the authors.
Journal ArticleDOI
Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations.
Balaraman Kalyanaraman,Victor M. Darley-Usmar,Kelvin J.A. Davies,Phyllis A. Dennery,Henry Jay Forman,Henry Jay Forman,Matthew B. Grisham,Giovanni E. Mann,Kevin P. Moore,L. Jackson Roberts,Harry Ischiropoulos +10 more
TL;DR: A critical analysis of the challenges and limitations of the most widely used fluorescent probes for detecting and measuring reactive oxygen and nitrogen species and proposed guidelines that will help present and future researchers with regard to the optimal use of selected fluorescent probes and interpretation of results are presented.
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Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity
Frank Weinberg,Robert B. Hamanaka,William W. Wheaton,Samuel E. Weinberg,Joy Joseph,Marcos Lopez,Balaraman Kalyanaraman,Gökhan M. Mutlu,G. R. Scott Budinger,Navdeep S. Chandel +9 more
TL;DR: It is reported that the major function of glucose metabolism for Kras-induced anchorage-independent growth, a hallmark of transformed cells, is to support the pentose phosphate pathway.
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Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives.
Homero Rubbo,Rafael Radi,M Trujillo,R. Telleri,Balaraman Kalyanaraman,Stephen Barnes,Marion Kirk,Bruce A. Freeman +7 more
TL;DR: In this paper, the influence of NO on membrane lipid peroxidation induced by O2-, H2O2, and OH derived from xanthine oxidase (XO) and by ONOO- was assessed by formation of thiobarbituric acid-reactive products and by liquid chromatography-mass spectrometry.
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Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications
Jacek Zielonka,Joy Joseph,Adam Sikora,Micael Hardy,Olivier Ouari,Jeannette Vasquez-Vivar,Gang Cheng,Marcos Lopez,Balaraman Kalyanaraman +8 more
TL;DR: The physicochemical basis for mitochondrial accumulation of lipophilic cations, synthetic chemistry strategies to target compounds to mitochondria, mitochondrial probes, and sensors, and examples of mitochondrial targeting of bioactive compounds are described.