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Benjamin D. Pope
Researcher at Wyss Institute for Biologically Inspired Engineering
Publications - 25
Citations - 3510
Benjamin D. Pope is an academic researcher from Wyss Institute for Biologically Inspired Engineering. The author has contributed to research in topics: Replication timing & DNA Replication Timing. The author has an hindex of 16, co-authored 25 publications receiving 2790 citations. Previous affiliations of Benjamin D. Pope include Harvard University & Florida State University.
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Journal ArticleDOI
A comparative encyclopedia of DNA elements in the mouse genome
Feng Yue,Feng Yue,Yong Cheng,Alessandra Breschi,Jeff Vierstra,Weisheng Wu,Weisheng Wu,Tyrone Ryba,Tyrone Ryba,Richard Sandstrom,Zhihai Ma,Carrie A. Davis,Benjamin D. Pope,Yin Shen,Dmitri D. Pervouchine,Sarah Djebali,Robert E. Thurman,Rajinder Kaul,Eric Rynes,Anthony Kirilusha,Georgi K. Marinov,Brian A. Williams,Diane Trout,Henry Amrhein,Katherine I. Fisher-Aylor,Igor Antoshechkin,Gilberto DeSalvo,Lei Hoon See,Meagan Fastuca,Jorg Drenkow,Chris Zaleski,Alexander Dobin,Pablo Prieto,Julien Lagarde,Giovanni Bussotti,Andrea Tanzer,Olgert Denas,Kanwei Li,M. A. Bender,M. A. Bender,Miaohua Zhang,Rachel Byron,Mark Groudine,Mark Groudine,David McCleary,Long Pham,Zhen Ye,Samantha Kuan,Lee Edsall,Yi-Chieh Wu,Matthew D. Rasmussen,Mukul S. Bansal,Manolis Kellis,Manolis Kellis,Cheryl A. Keller,Christapher S. Morrissey,Tejaswini Mishra,Deepti Jain,Nergiz Dogan,Robert S. Harris,Philip Cayting,Trupti Kawli,Alan P. Boyle,Alan P. Boyle,Ghia Euskirchen,Anshul Kundaje,Shin Lin,Yiing Lin,Camden Jansen,Venkat S. Malladi,Melissa S. Cline,Drew T. Erickson,Vanessa M. Kirkup,Katrina Learned,Cricket A. Sloan,Kate R. Rosenbloom,Beatriz Lacerda de Sousa,Kathryn Beal,Miguel Pignatelli,Paul Flicek,Jin Lian,Tamer Kahveci,Dongwon Lee,W. James Kent,Miguel Santos,Javier Herrero,Cedric Notredame,Audra K. Johnson,Shinny Vong,Kristen Lee,Daniel Bates,Fidencio Neri,Morgan Diegel,Theresa K. Canfield,Peter J. Sabo,Matthew S. Wilken,Thomas A. Reh,Erika Giste,Anthony Shafer,Tanya Kutyavin,Eric Haugen,Douglas Dunn,Alex Reynolds,Shane Neph,Richard Humbert,R. Scott Hansen,Marella F. T. R. de Bruijn,Licia Selleri,Alexander Y. Rudensky,Steven Z. Josefowicz,Robert M. Samstein,Evan E. Eichler,Stuart H. Orkin,Dana N. Levasseur,Thalia Papayannopoulou,Kai Hsin Chang,Arthur I. Skoultchi,Srikanta Gosh,Christine M. Disteche,Piper M. Treuting,Yanli Wang,Mitchell J. Weiss,Gerd A. Blobel,Xiaoyi Cao,Sheng Zhong,Ting Wang,Peter J. Good,Rebecca F. Lowdon,Rebecca F. Lowdon,Leslie B. Adams,Leslie B. Adams,Xiao Qiao Zhou,Michael J. Pazin,Elise A. Feingold,Barbara J. Wold,James Taylor,Ali Mortazavi,Sherman M. Weissman,John A. Stamatoyannopoulos,Michael Snyder,Roderic Guigó,Thomas R. Gingeras,David M. Gilbert,Ross C. Hardison,Michael A. Beer,Bing Ren +145 more
TL;DR: The mouse ENCODE Consortium has mapped transcription, DNase I hypersensitivity, transcription factor binding, chromatin modifications and replication domains throughout the mouse genome in diverse cell and tissue types as mentioned in this paper.
Journal ArticleDOI
Topologically associating domains are stable units of replication-timing regulation
Benjamin D. Pope,Tyrone Ryba,Vishnu Dileep,Feng Yue,Weisheng Wu,Olgert Denas,Daniel L. Vera,Yanli Wang,R. Scott Hansen,Theresa K. Canfield,Robert E. Thurman,Yong Cheng,Günhan Gülsoy,Jonathan H. Dennis,Michael Snyder,John A. Stamatoyannopoulos,James Taylor,Ross C. Hardison,Tamer Kahveci,Bing Ren,David M. Gilbert +20 more
TL;DR: It is demonstrated that, collectively, replication domain boundaries share a near one-to-one correlation with TAD boundaries, whereas within a cell type, adjacent TADs that replicate at similar times obscure replicationdomain boundaries, largely accounting for the previously reported lack of alignment.
Journal ArticleDOI
Independence of Repressive Histone Marks and Chromatin Compaction during Senescent Heterochromatic Layer Formation
Tamir Chandra,Kristina Kirschner,Jean Yves Thuret,Benjamin D. Pope,Tyrone Ryba,Scott Newman,Kashif Ahmed,Shamith A. Samarajiwa,Rafik Salama,Thomas L. Carroll,Rory Stark,Rekin's Janky,Masako Narita,Lixiang Xue,Agustin Chicas,Sabrina Nũnez,Ralf Janknecht,Yoko Hayashi-Takanaka,Michael D. Wilson,Aileen Marshall,Duncan T. Odom,M. Madan Babu,David P. Bazett-Jones,Simon Tavaré,Paul A.W. Edwards,Scott W. Lowe,Scott W. Lowe,Hiroshi Kimura,David M. Gilbert,Masashi Narita +29 more
TL;DR: The experiments reveal that high-order heterochromatin formation and epigenetic remodeling of the genome can be discrete events.
A comparative encyclopedia of DNA elements in the mouse genome
Feng Yue,Feng Yue,Yong Cheng,Alessandra Breschi,Jeff Vierstra,Weisheng Wu,Weisheng Wu,Tyrone Ryba,Tyrone Ryba,Richard Sandstrom,Zhihai Ma,Carrie A. Davis,Benjamin D. Pope,Yin Shen,Dmitri D. Pervouchine,Sarah Djebali,Robert E. Thurman,Rajinder Kaul,Eric Rynes,Anthony Kirilusha,Georgi K. Marinov,Brian A. Williams,Diane Trout,Henry Amrhein,Katherine I. Fisher-Aylor,Igor Antoshechkin,Gilberto DeSalvo,Lei Hoon See,Meagan Fastuca,Jorg Drenkow,Chris Zaleski,Alexander Dobin,Pablo Prieto,Julien Lagarde,Giovanni Bussotti,Andrea Tanzer,Olgert Denas,Kanwei Li,M. A. Bender,M. A. Bender,Miaohua Zhang,Rachel Byron,Mark Groudine,Mark Groudine,David McCleary,Long Pham,Zhen Ye,Samantha Kuan,Lee Edsall,Yi-Chieh Wu,Matthew D. Rasmussen,Mukul S. Bansal,Manolis Kellis,Manolis Kellis,Cheryl A. Keller,Christapher S. Morrissey,Tejaswini Mishra,Deepti Jain,Nergiz Dogan,Robert S. Harris,Philip Cayting,Trupti Kawli,Alan P. Boyle,Alan P. Boyle,Ghia Euskirchen,Anshul Kundaje,Shin Lin,Yiing Lin,Camden Jansen,Venkat S. Malladi,Melissa S. Cline,Drew T. Erickson,Vanessa M. Kirkup,Katrina Learned,Cricket A. Sloan,Kate R. Rosenbloom,Beatriz Lacerda de Sousa,Kathryn Beal,Miguel Pignatelli,Paul Flicek,Jin Lian,Tamer Kahveci,Dongwon Lee,W. James Kent,Miguel Santos,Javier Herrero,Cedric Notredame,Audra K. Johnson,Shinny Vong,Kristen Lee,Daniel Bates,Fidencio Neri,Morgan Diegel,Theresa K. Canfield,Peter J. Sabo,Matthew S. Wilken,Thomas A. Reh,Erika Giste,Anthony Shafer,Tanya Kutyavin,Eric Haugen,Douglas Dunn,Alex Reynolds,Shane Neph,Richard Humbert,R. Scott Hansen,Marella F. T. R. de Bruijn,Licia Selleri,Alexander Y. Rudensky,Steven Z. Josefowicz,Robert M. Samstein,Evan E. Eichler,Stuart H. Orkin,Dana N. Levasseur,Thalia Papayannopoulou,Kai Hsin Chang,Arthur I. Skoultchi,Srikanta Gosh,Christine M. Disteche,Piper M. Treuting,Yanli Wang,Mitchell J. Weiss,Gerd A. Blobel,Xiaoyi Cao,Sheng Zhong,Ting Wang,Peter J. Good,Rebecca F. Lowdon,Rebecca F. Lowdon,Leslie B. Adams,Leslie B. Adams,Xiao Qiao Zhou,Michael J. Pazin,Elise A. Feingold,Barbara J. Wold,James Taylor,Ali Mortazavi,Sherman M. Weissman,John A. Stamatoyannopoulos,Michael Snyder,Roderic Guigó,Thomas R. Gingeras,David M. Gilbert,Ross C. Hardison,Michael A. Beer,Bing Ren +145 more
TL;DR: By comparing with the human genome, this work not only confirms substantial conservation in the newly annotated potential functional sequences, but also finds a large degree of divergence of sequences involved in transcriptional regulation, chromatin state and higher order chromatin organization.
Journal ArticleDOI
Genome-scale analysis of replication timing: from bench to bioinformatics
TL;DR: This protocol describes how to analyze genome-wide replication timing (RT) in mammalian cells and presents a guide to analyzing the resulting data sets based on methods used routinely and covers clustering methods and means to relate changes in the replication program to gene expression and other genetic and epigenetic data sets.