Camden Jansen

TL;DR: The mouse ENCODE Consortium has mapped transcription, DNase I hypersensitivity, transcription factor binding, chromatin modifications and replication domains throughout the mouse genome in diverse cell and tissue types as mentioned in this paper.

TL;DR: By comparing with the human genome, this work not only confirms substantial conservation in the newly annotated potential functional sequences, but also finds a large degree of divergence of sequences involved in transcriptional regulation, chromatin state and higher order chromatin organization.

TL;DR: It is shown that both activation and repression target genes can be bound by Bcl11b in vivo, and that B cl11b effects overlap with E2A-dependent effects, resolving how innate lymphoid, myeloid, and dendritic, and B-cell fate alternatives are excluded by different mechanisms.

TL;DR: In this article, a detailed phenotypic characterization of the 5xFAD model on a congenic C57BL/6 J strain was conducted across its lifespan, including a seldomly analyzed 18-month old time point.

TL;DR: Data and analyses from chromatin immunoprecipitation followed by high-throughput sequencing (ChIP–seq) experiments using the human HepG2 cell line are presented, providing a comprehensive catalogue of the transcription factor landscape and gene regulatory networks in these cells.