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Bruce W. Birren
Researcher at Broad Institute
Publications - 215
Citations - 125222
Bruce W. Birren is an academic researcher from Broad Institute. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 103, co-authored 205 publications receiving 113491 citations. Previous affiliations of Bruce W. Birren include Massachusetts Institute of Technology & California Institute of Technology.
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Journal ArticleDOI
Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence
Daniel E. Neafsey,Stephen F. Schaffner,Sarak K. Volkman,Sarak K. Volkman,Daniel J. Park,Philip Montgomery,Danny A. Milner,Amanda K. Lukens,David I. Rosen,Rachel F. Daniels,Nathan Houde,Joseph F. Cortese,Erin Tyndall,Casey Gates,Nicole Stange-Thomann,Ousmane Sarr,Daouda Ndiaye,Omar Ndir,S. Mboup,Marcelo U. Ferreira,Sandra do Lago Moraes,Aditya P Dash,Chetan E. Chitnis,Roger C. Wiegand,Daniel L. Hartl,Bruce W. Birren,Eric S. Lander,Pardis C. Sabeti,Dyann F. Wirth +28 more
TL;DR: The distinct population profile of nonsynonymous variants indicates that natural selection has a significant influence on genomic diversity in P. falciparum, and that many of these changes may reflect functional variants deserving of follow-up study.
Journal ArticleDOI
Uneven chromosome contraction and expansion in the maize genome
Rémy Bruggmann,Arvind K. Bharti,Heidrun Gundlach,Jinsheng Lai,Sarah Young,Ana Clara Pontaroli,Fusheng Wei,Georg Haberer,Galina Fuks,Chunguang Du,Christina Raymond,Matt C. Estep,Renyi Liu,Jeffrey L. Bennetzen,Agnes P. Chan,Pablo D. Rabinowicz,John Quackenbush,W. Brad Barbazuk,Rod A. Wing,Bruce W. Birren,Chad Nusbaum,Steve Rounsley,Klaus F. X. Mayer,Joachim Messing +23 more
TL;DR: In this article, the authors sequenced the two copies of one such region, generating 7.8 Mb of sequence spanning 17.4 cM of the short arm of chromosome 1 and 6.6 Mb (25.6 cM) from the long arm of chromosomes 9.
Journal ArticleDOI
Sequence and Comparative Analysis of the Mouse 1-Megabase Region Orthologous to the Human 11p15 Imprinted Domain
Patrick Onyango,Webb Miller,Jessica A. Lehoczky,Cheuk T. Leung,Bruce W. Birren,Sarah J. Wheelan,Sarah J. Wheelan,Ken Dewar,Andrew P. Feinberg +8 more
TL;DR: This study provides the first global view of the architecture of an entire imprinted domain and provides candidate sequence elements for subsequent functional analyses.
Journal ArticleDOI
Longitudinal genomic surveillance of Plasmodium falciparum malaria parasites reveals complex genomic architecture of emerging artemisinin resistance
Gustavo C. Cerqueira,Ian H. Cheeseman,Stephen F. Schaffner,Shalini Nair,Marina McDew-White,Aung Pyae Phyo,Elizabeth A. Ashley,Elizabeth A. Ashley,Alexandre Melnikov,Peter Rogov,Bruce W. Birren,François Nosten,François Nosten,Tim J. Anderson,Daniel E. Neafsey +14 more
TL;DR: Evidence for additional genomic regions outside of the kelch13 locus associated with artemisinin-resistant parasites may yield new molecular markers for resistance surveillance, which may be useful in efforts to reduce the emergence or spread of artemis inin resistance in African parasite populations.
Journal ArticleDOI
The Early Whole-Blood Transcriptional Signature of Dengue Virus and Features Associated with Progression to Dengue Shock Syndrome in Vietnamese Children and Young Adults
Long T. Hoang,David J. Lynn,Matt Henn,Bruce W. Birren,Niall J. Lennon,Phuong Thi Le,Kien Thi Hue Duong,Tham Thi Hong Nguyen,Lanh Ngoc Mai,Jeremy Farrar,Martin L. Hibberd,Cameron P. Simmons +11 more
TL;DR: A nested case-control comparison of the early host transcriptional features in 24 DSS patients and 56 sex-, age-, and virus serotype-matched uncomplicated dengue patients suggests a hitherto unrecognized association between neutrophil activation, pathogenesis, and the development of DSS.