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Bruce W. Birren
Researcher at Broad Institute
Publications - 215
Citations - 125222
Bruce W. Birren is an academic researcher from Broad Institute. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 103, co-authored 205 publications receiving 113491 citations. Previous affiliations of Bruce W. Birren include Massachusetts Institute of Technology & California Institute of Technology.
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Journal ArticleDOI
Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis
Jörg Kämper,Regine Kahmann,Michael Bölker,Li-Jun Ma,Thomas Brefort,Barry J. Saville,Barry J. Saville,Flora Banuett,James W. Kronstad,Scott E. Gold,Olaf Müller,Michael H. Perlin,Han A. B. Wösten,Ronald P. de Vries,Jose Ruiz-Herrera,Cristina G. Reynaga-Peña,Karen M. Snetselaar,Michael P. McCann,José Pérez-Martín,Michael Feldbrügge,Christoph W. Basse,Gero Steinberg,José I. Ibeas,William K. Holloman,Plinio Guzmán,Mark L. Farman,Jason E. Stajich,Rafael Sentandreu,Juan Manuel González-Prieto,John C. Kennell,Lazaro Molina,Jan Schirawski,Artemio Mendoza-Mendoza,Doris Greilinger,Karin Münch,Nicole Rössel,Mario Scherer,Miroslav Vranes,Oliver Ladendorf,Volker Vincon,Uta Fuchs,Björn Sandrock,Shaowu Meng,Eric C.H. Ho,Matt J. Cahill,Kylie J. Boyce,Jana Klose,Steven J. Klosterman,Heine J. Deelstra,Lucila Ortiz-Castellanos,Weixi Li,Patricia Sánchez-Alonso,Peter Schreier,Isolde Häuser-Hahn,Martin Vaupel,Edda Koopmann,Gabi Friedrich,Hartmut Voss,Thomas Schlüter,Jonathan Margolis,Darren Mark Platt,Candace Swimmer,Andreas Gnirke,Feng Chen,Valentina Vysotskaia,Gertrud Mannhaupt,Ulrich Güldener,Martin Münsterkötter,Dirk Haase,Matthias Oesterheld,Hans-Werner Mewes,Evan Mauceli,David DeCaprio,Claire M. Wade,Jonathan Butler,Sarah Young,David B. Jaffe,Sarah E. Calvo,Chad Nusbaum,James E. Galagan,Bruce W. Birren +80 more
TL;DR: The discovery of the secreted protein gene clusters and the functional demonstration of their decisive role in the infection process illuminate previously unknown mechanisms of pathogenicity operating in biotrophic fungi.
Journal ArticleDOI
Genome sequence of Aedes aegypti, a major arbovirus vector
Vishvanath Nene,Jennifer R. Wortman,Daniel Lawson,Brian J. Haas,Chinnappa D. Kodira,Zhijian Jake Tu,Brendan J. Loftus,Zhiyong Xi,Karyn Megy,Manfred Grabherr,Quinghu Ren,Evgeny M. Zdobnov,Neil F. Lobo,Kathryn S. Campbell,Susan E. Brown,Maria de Fatima Bonaldo,Jingsong Zhu,Steven P. Sinkins,David G. Hogenkamp,Paolo Amedeo,Peter Arensburger,Peter W. Atkinson,Shelby L. Bidwell,Jim Biedler,Ewan Birney,Robert V. Bruggner,Javier Costas,Monique R. Coy,Jonathan Crabtree,Matt Crawford,Becky deBruyn,David DeCaprio,Karin Eiglmeier,Eric Eisenstadt,Hamza El-Dorry,William M. Gelbart,Suely Lopes Gomes,Martin Hammond,Linda Hannick,James R. Hogan,Michael H. Holmes,David M. Jaffe,J. Spencer Johnston,Ryan C. Kennedy,Hean Koo,Saul A. Kravitz,Evgenia V. Kriventseva,David Kulp,Kurt LaButti,Eduardo Lee,Song Li,Diane D. Lovin,Chunhong Mao,Evan Mauceli,Carlos Frederico Martins Menck,Jason R. Miller,Philip Montgomery,Akio Mori,Ana L. T. O. Nascimento,Horacio Naveira,Chad Nusbaum,Sinéad B. O'Leary,Joshua Orvis,Mihaela Pertea,Hadi Quesneville,Kyanne R. Reidenbach,Yu-Hui Rogers,Charles Roth,Jennifer R. Schneider,Michael C. Schatz,Martin Shumway,Mario Stanke,Eric O. Stinson,Jose M. C. Tubio,Janice P. Vanzee,Sergio Verjovski-Almeida,Doreen Werner,Owen White,Stefan Wyder,Qiandong Zeng,Qi Zhao,Yongmei Zhao,Catherine A. Hill,Alexander S. Raikhel,Marcelo B. Soares,Dennis L. Knudson,Norman H. Lee,James E. Galagan,Steven L. Salzberg,Ian T. Paulsen,George Dimopoulos,Frank H. Collins,Bruce W. Birren,Claire M. Fraser-Liggett,David W. Severson +94 more
TL;DR: A draft sequence of the genome of Aedes aegypti, the primary vector for yellow fever and dengue fever, which at approximately 1376 million base pairs is about 5 times the size of the genomes of the malaria vector Anopheles gambiae was presented in this paper.
Journal ArticleDOI
Evolution of pathogenicity and sexual reproduction in eight Candida genomes.
Geraldine Butler,Matthew D. Rasmussen,Michael F. Lin,Michael F. Lin,Manuel A. S. Santos,Sharadha Sakthikumar,Carol A. Munro,Esther Rheinbay,Esther Rheinbay,Manfred Grabherr,Anja Forche,Jennifer L. Reedy,Ino Agrafioti,Martha B. Arnaud,Steven Bates,Alistair J. P. Brown,Sascha Brunke,Maria C. Costanzo,David A. Fitzpatrick,Piet W. J. de Groot,David Harris,Lois L. Hoyer,Bernhard Hube,Frans M. Klis,Chinnappa D. Kodira,Nicola Lennard,Mary E. Logue,Ronny Martin,Aaron M. Neiman,Elissavet Nikolaou,Michael A. Quail,Janet Quinn,Maria C. Santos,Florian F. Schmitzberger,Gavin Sherlock,Prachi Shah,Kevin A. T. Silverstein,Marek S. Skrzypek,David R. Soll,Rodney Staggs,Ian Stansfield,Michael P. H. Stumpf,Peter E. Sudbery,Thyagarajan Srikantha,Qiandong Zeng,Judith Berman,Matthew Berriman,Joseph Heitman,Neil A. R. Gow,Michael C. Lorenz,Bruce W. Birren,Manolis Kellis,Manolis Kellis,Christina A. Cuomo +53 more
TL;DR: There are significant expansions of cell wall, secreted and transporter gene families in pathogenic species, suggesting adaptations associated with virulence in Candida albicans species.
Journal ArticleDOI
The Fusarium graminearum Genome Reveals a Link Between Localized Polymorphism and Pathogen Specialization
Christina A. Cuomo,Ulrich Güldener,Jin-Rong Xu,Frances Trail,B. Gillian Turgeon,Antonio Di Pietro,Jonathan D. Walton,Li-Jun Ma,Scott E. Baker,Martijn Rep,Gerhard Adam,John F. Antoniw,Thomas K. Baldwin,Sarah E. Calvo,Yueh-Long Chang,David DeCaprio,Liane R. Gale,Sante Gnerre,Rubella S. Goswami,Kim E. Hammond-Kosack,Linda J. Harris,Karen Hilburn,John C. Kennell,Scott Kroken,Jon K. Magnuson,Gertrud Mannhaupt,Evan Mauceli,Hans-Werner Mewes,Rudolf Mitterbauer,Gary J. Muehlbauer,Martin Münsterkötter,David R. Nelson,Kerry O'Donnell,Thérèse Ouellet,Weihong Qi,Hadi Quesneville,M. Isabel G. Roncero,Kye Yong Seong,Igor V. Tetko,Martin Urban,Cees Waalwijk,Todd J. Ward,Jiqiang Yao,Bruce W. Birren,H. Corby Kistler,H. Corby Kistler +45 more
TL;DR: The genome of the filamentous fungus Fusarium graminearum, a major pathogen of cultivated cereals, was sequenced and annotated and many highly polymorphic regions contained sets of genes implicated in plant-fungus interactions and were unusually divergent, with higher rates of recombination.
Journal ArticleDOI
An STS-Based Map of the Human Genome
Thomas J. Hudson,Lincoln D. Stein,Sebastian S. Gerety,Junli Ma,Andrew B. Castle,James Silva,Donna K. Slonim,Rafael Baptista,Leonid Kruglyak,Shu-Hua Xu,Xintong Hu,Angela M. E. Colbert,Carl Rosenberg,Mary Pat Reeve-Daly,Steve Rozen,Lester Hui,Xiaoyun Wu,Christina Vestergaard,Kimberly M. Wilson,Jane S. Bae,Shanak Maitra,Soula Ganiatsas,Cheryl A. Evans,Margaret M. DeAngelis,Kimberly A. Ingalls,Robert Nahf,Lloyd T. Horton,Michele Oskin Anderson,Alville Collymore,Wenjuan Ye,Vardouhie Kouyoumjian,Irena S. Zemsteva,James P. Tam,Richard Devine,Dorothy F. Courtney,Michelle Turner Renaud,Huy Nguyen,Tara J. O'Connor,Cécile Fizames,Sabine Fauré,Gabor Gyapay,Colette Dib,Jean Morissette,James B. Orlin,Bruce W. Birren,Nathan Goodman,Jean Weissenbach,Trevor Hawkins,Simon J. Foote,David C. Page,Eric S. Lander +50 more
TL;DR: A physical map has been constructed of the human genome containing 15,086 sequence-tagged sites (STSs), with an average spacing of 199 kilobases, anchored by the radiation hybrid and genetic maps.