Jishnu Das

TL;DR: HINT addresses the ubiquitous need of having a repository of high-quality protein-protein interactions and can be utilized to generate specific hypotheses about specific proteins and/or pathways, as well as analyzing global properties of cellular networks.

TL;DR: It is found that in-frame mutations are enriched on the interaction interfaces of proteins associated with the corresponding disorders, and that the disease specificity for different mutations of the same gene can be explained by their location within an interface.

TL;DR: In this article, the authors used patterns of polymorphisms in functionally annotated regions in 1092 humans to identify deleterious variants; then, they experimentally validated candidates, finding regions particularly sensitive to mutations and variants that are disruptive because of mechanistic effects on transcription-factor binding.

TL;DR: Antibiotics treatment prior and subsequent to seasonal influenza vaccination revealed significant associations between bacterial species and metabolic phenotypes, highlighting a key role for the microbiome in modulating human immunity.

TL;DR: Antibody-mediated effector functions, including phagocytosis and NK cell activation, were associated with protection, particularly for antibodies with moderate neutralizing activity, and this framework identifies functional correlates that can inform therapeutic and vaccine design strategies against EBOV and other pathogens.