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Chad Nusbaum
Researcher at Massachusetts Institute of Technology
Publications - 70
Citations - 69227
Chad Nusbaum is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 48, co-authored 69 publications receiving 62980 citations. Previous affiliations of Chad Nusbaum include Barts Health NHS Trust & Uniformed Services University of the Health Sciences.
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A High-Throughput Chromatin Immunoprecipitation Approach Reveals Principles of Dynamic Gene Regulation in Mammals
Manuel Garber,Nir Yosef,Nir Yosef,Alon Goren,Raktima Raychowdhury,Anne Thielke,Mitchell Guttman,Mitchell Guttman,James T. Robinson,Brian Minie,Nicolas Chevrier,Zohar Itzhaki,Ronnie Blecher-Gonen,Chamutal Bornstein,Daniela Amann-Zalcenstein,Assaf Weiner,Dennis C. Friedrich,James Meldrim,Oren Ram,Christine S. Cheng,Christine S. Cheng,Andreas Gnirke,Sheila Fisher,Nir Friedman,Bang Wong,Bradley E. Bernstein,Bradley E. Bernstein,Chad Nusbaum,Nir Hacohen,Nir Hacohen,Aviv Regev,Aviv Regev,Aviv Regev,Ido Amit,Ido Amit +34 more
TL;DR: A high-throughput Chromatin ImmunoPrecipitation (HT-ChIP) method is developed to systematically map protein-DNA interactions and suggests a model for transcription regulation whereby TF networks are hierarchically organized into cell differentiation factors, factors that bind targets prior to stimulus to prime them for induction, and factors that regulate specific gene programs.
Metabolic labeling of RNA uncovers principles of RNA production and degradation dynamics in mammalian cells
Michal Rabani,Joshua Z. Levin,Lin Fan,Xian Adiconis,Raktima Raychowdhury,Manuel Garber,Andreas Gnirke,Chad Nusbaum,Nir Hacohen,Nir Friedman,Ido Amit,Aviv Regev,Aviv Regev +12 more
TL;DR: This article used metabolic labeling of RNA at high temporal resolution with advanced RNA quantification and computational modeling to estimate RNA transcription and degradation rates during the response of mouse dendritic cells to lipopolysaccharide.
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Th17 reprogramming of T cells in systemic juvenile idiopathic arthritis
Lauren A. Henderson,Kacie J Hoyt,Pui Y. Lee,Deepak A. Rao,A. Helena Jonsson,Jennifer P Nguyen,Kayleigh Rutherford,Amélie M Julé,Louis-Marie Charbonnier,Siobhan M. Case,Margaret H. Chang,Ezra M. Cohen,Fatma Dedeoglu,Robert C. Fuhlbrigge,Olha Halyabar,Melissa M. Hazen,Erin Janssen,Susan Kim,Jeffrey Lo,Mindy S. Lo,Esra Meidan,Mary Beth F. Son,Robert P. Sundel,Matthew L. Stoll,Chad Nusbaum,James A. Lederer,Talal A. Chatila,Peter A. Nigrovic +27 more
TL;DR: Findings identify evolving Th17 polarization in sJIA that begins in Tregs and progresses to Teffs, likely reflecting the impact of the cytokine milieu and consistent with a biphasic model of disease pathogenesis.
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Mapping of Myxococcus xanthus Social Motility dsp Mutations to the dif Genes
Hope Lancero,Jennifer E. Brofft,John Downard,Bruce W. Birren,Chad Nusbaum,Jerome Naylor,Wenyuan Shi,Lawrence J. Shimkets +7 more
TL;DR: Myxococcus xanthus dsp and dif mutants have similar phenotypes in that they are deficient in social motility and fruiting body development and found that 16 of the 18 dsp alleles map to the dif genes.
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Complete Genome Sequence of Algoriphagus sp. PR1, Bacterial Prey of a Colony-Forming Choanoflagellate
Rosanna A. Alegado,Steven Ferriera,Steven Ferriera,Chad Nusbaum,Sarah Young,Qian Zeng,Alma Imamovic,Stephen R. Fairclough,Nicole King +8 more
TL;DR: The complete genome sequence of Algoriphagus sp.