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Chad Nusbaum
Researcher at Massachusetts Institute of Technology
Publications - 70
Citations - 69227
Chad Nusbaum is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 48, co-authored 69 publications receiving 62980 citations. Previous affiliations of Chad Nusbaum include Barts Health NHS Trust & Uniformed Services University of the Health Sciences.
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Patent
Selection of nucleic acids by solution hybridization to oligonucleotide baits
TL;DR: In this paper, methods of selection of nucleic acids using solution hybridization, methods of sequencing nucleic acid including such selection methods, and products for use in the methods are disclosed.
Journal Article
A framework for human microbiome research
Barbara A. Methé,Karen E. Nelson,Mihai Pop,Heather Huot Creasy,Michelle G. Giglio,Curtis Huttenhower,Dirk Gevers,Joseph F. Petrosino,Sahar Abubucker,Jonathan H. Badger,Asif T. Chinwalla,Ashlee M. Earl,Michael Fitzgerald,Robert S. Fulton,Kymberlie Hallsworth-Pepin,Elizabeth A. Lobos,Ramana Madupu,Vincent Magrini,John Martin,Makedonka Mitreva,Donna M. Muzny,Erica Sodergren,James Versalovic,Aye Wollam,Kim C. Worley,Jennifer R. Wortman,Sarah Young,Qiandong Zeng,Kjersti Aagaard,Olukemi O. Abolude,Emma Allen-Vercoe,Eric J. Alm,Lucia Alvarado,Gary L. Andersen,Scott Anderson,Elizabeth L. Appelbaum,Harindra Arachchi,Gary C. Armitage,Cesar Arze,Tulin Ayvaz,Carl C. Baker,Lisa Begg,Tsegahiwot Belachew,Veena Bhonagiri,Monika Bihan,Martin J. Blaser,Toby Bloom,Vivien Bonazzi,Paul Brooks,Gregory A. Buck,Christian J. Buhay,Dana A. Busam,Joseph L. Campbell,Shane Canon,Brandi L. Cantarel,Patrick S. G. Chain,I-Min A. Chen,Lei Chen,Shaila Chhibba,Ken Chu,Dawn Ciulla,Jose C. Clemente,Sandra W. Clifton,Sean Conlan,Jonathan Crabtree,Mary A. Cutting,Noam J. Davidovics,Catherine C. Davis,Todd Z. DeSantis,Carolyn Deal,Kimberley D. Delehaunty,Floyd E. Dewhirst,Elena Deych,Yan Ding,David J. Dooling,Shannon Dugan,W. Michael Dunne,A. Scott Durkin,Robert C. Edgar,Rachel L. Erlich,Candace N. Farmer,Ruth M. Farrell,Karoline Faust,Michael Feldgarden,Victor Felix,Sheila A. Fisher,Anthony A. Fodor,Larry J. Forney,Leslie Foster,Valentina Di Francesco,Jonathan Friedman,Dennis C. Friedrich,Catrina Fronick,Lucinda Fulton,Hongyu Gao,Nathalia Garcia,Georgia Giannoukos,Christina Giblin,Maria Y. Giovanni,Jonathan M. Goldberg,Johannes B. Goll,Antonio Gonzalez,Allison D. Griggs,Sharvari Gujja,Brian J. Haas,Holli A. Hamilton,Emily L. Harris,Theresa A. Hepburn,Brandi Herter,Diane E. Hoffmann,Michael Holder,Clinton Howarth,Katherine H. Huang,Susan M. Huse,Jacques Izard,Janet K. Jansson,Huaiyang Jiang,Craig T. Jordan,Vandita Joshi,James A. Katancik,Wendy A. Keitel,Scott T. Kelley,Cristyn Kells,Susan Kinder-Haake,Nicholas B. King,Rob Knight,Dan Knights,Heidi H. Kong,Omry Koren,Sergey Koren,Karthik Kota,Christie Kovar,Nikos C. Kyrpides,Patricio S. La Rosa,Sandra L. Lee,Katherine P. Lemon,Niall J. Lennon,Cecil M. Lewis,Lora Lewis,Ruth E. Ley,Kelvin Li,Konstantinos Liolios,Bo Liu,Yue Liu,Chien-Chi Lo,Catherine A. Lozupone,R. Dwayne Lunsford,Tessa Madden,Anup Mahurkar,Peter J. Mannon,Elaine R. Mardis,Victor M. Markowitz,Konstantinos Mavrommatis,Jamison McCorrison,Daniel McDonald,Jean E. McEwen,Amy L. McGuire,Pamela McInnes,Teena Mehta,Kathie A. Mihindukulasuriya,Jason R. Miller,Patrick Minx,Irene Newsham,Chad Nusbaum,Michelle O'Laughlin,Joshua Orvis,Ioanna Pagani,Krishna Palaniappan,Shital M. Patel,Matthew D. Pearson,Jane Peterson,Mircea Podar,Craig Pohl,Katherine S. Pollard,Margaret Priest,Lita M. Proctor,Xiang Qin,Jeroen Raes,Jacques Ravel,Jeffrey G. Reid,Mina Rho,Rosamond Rhodes,Kevin Riehle,Maria C. Rivera,Beltran Rodriguez-Mueller,Yu-Hui Rogers,Matthew C. Ross,Carsten Russ,Ravi Sanka,Pamela Sankar,J. Fah Sathirapongsasuti,Jeffery A. Schloss,Patrick D. Schloss,Thomas M. Schmidt,Matthew B. Scholz,Lynn M. Schriml,Alyxandria M. Schubert,Nicola Segata,Julia A. Segre,William D. Shannon,Richard R. Sharp,Thomas J. Sharpton,Narmada Shenoy,Nihar U. Sheth,Gina A. Simone,Indresh Singh,Christopher Smillie,Jack D. Sobel,Daniel D. Sommer,Paul Spicer,Granger G. Sutton,Sean M. Sykes,Diana Tabbaa,Mathangi Thiagarajan,Chad Tomlinson,Manolito Torralba,Todd J. Treangen,Rebecca Truty,Tatiana A. Vishnivetskaya,Jason Walker,Lu Wang,Zhengyuan Wang,Doyle V. Ward,Wesley C. Warren,Mark A. Watson,Christopher Wellington,Kris A. Wetterstrand,James R. White,Katarzyna Wilczek-Boney,Yuan Qing Wu,Kristine M. Wylie,Todd Wylie,Chandri N. Yandava,Liang Ye,Yuzhen Ye,Shibu Yooseph,Bonnie P. Youmans,Lan Zhang,Yanjiao Zhou,Yiming Zhu,Laurie Zoloth,Jeremy Zucker,Bruce W. Birren,Richard A. Gibbs,Sarah K. Highlander,George M. Weinstock,Richard K. Wilson,Owen White +247 more
TL;DR: Resources from a population of 242 healthy adults sampled at 15 or 18 body sites up to three times are presented, which have generated 5,177 microbial taxonomic profiles from 16S ribosomal RNA genes and over 3.5 terabases of metagenomic sequence so far.
Posted ContentDOI
Defining Inflammatory Cell States in Rheumatoid Arthritis Joint Synovial Tissues by Integrating Single-cell Transcriptomics and Mass Cytometry
Fan Zhang,Kevin Wei,Kamil Slowikowski,Chamith Y. Fonseka,Deepak A. Rao,Stephen Kelly,Susan M. Goodman,Darren Tabechian,Laura B. Hughes,Karen Salomon-Escoto,Gerald F. Watts,William Apruzzese,David J. Lieb,David L. Boyle,Arthur M. Mandelin,Accelerating Medicines Partnership: Ra Phase,Amp Ra,Sle,Brendan F. Boyce,Edward F. DiCarlo,Ellen M. Gravallese,Peter K. Gregersen,Larry W. Moreland,Gary S. Firestein,Nir Hacohen,Chad Nusbaum,James A. Lederer,Harris Perlman,Costantino Pitzalis,Andrew Filer,V. Michael Holers,Vivian P. Bykerk,Laura T. Donlin,Jennifer H. Anolik,Michael B. Brenner,Soumya Raychaudhuri +35 more
TL;DR: Using bulk and single-cell data, inflammatory mediators to source cell populations are mapped, for example attributing IL6 production to THY1+HLAhigh fibroblasts and naïve B cells, and IL1B to pro-inflammatory monocytes, which are potentially key mediators of RA pathogenesis.
Journal ArticleDOI
Yeast sterol regulatory element-binding protein (SREBP) cleavage requires Cdc48 and Dsc5, a ubiquitin regulatory X domain-containing subunit of the Golgi Dsc E3 ligase.
Emerson V. Stewart,S. Julie-Ann Lloyd,John S. Burg,Christine C. Nwosu,Robert E. Lintner,Riza M. Daza,Carsten Russ,Karen Ponchner,Chad Nusbaum,Peter J. Espenshade +9 more
TL;DR: Results of a genetic selection designed to identify additional components required for Sre1 cleavage provide a mechanistic link between the Dsc E3 ligase complex and the proteasome in SREBP cleavage and add to a growing list of similarities between the Cdc48 and Dsc5 ligase subunits involved in endoplasmic reticulum-associated degradation.
Patent
Methods for shearing and tagging dna for chromatin immunoprecipitation and sequencing
Bradley E. Bernstein,Alon Goren,Chad Nusbaum,Oren Ram,Assaf Rotem,Daniel R. Tarjan,Jeffrey Xing,Aviv Regev +7 more
TL;DR: In this article, the transposon is made up of a first DNA molecule that includes a first transposase recognition site and a second DNA molecule including a second transposases recognition site, wherein the transposition integrates the first and second DNA molecules into chromatin DNA.