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Chad Nusbaum
Researcher at Massachusetts Institute of Technology
Publications - 70
Citations - 69227
Chad Nusbaum is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 48, co-authored 69 publications receiving 62980 citations. Previous affiliations of Chad Nusbaum include Barts Health NHS Trust & Uniformed Services University of the Health Sciences.
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Journal ArticleDOI
Radiation hybrid map of the mouse genome.
Van Etten Wj,Robert G. Steen,Huy Nguyen,Andrew B. Castle,Donna K. Slonim,Bing Ge,Chad Nusbaum,Greg Schuler,Eric S. Lander,Thomas J. Hudson,Thomas J. Hudson +10 more
TL;DR: The first comprehensive RH map of the mouse genome is reported, providing essentially complete connectivity and coverage across the genome, and good resolution for ordering loci, with 1 centiRay (cR) corresponding to an average of approximately 100 kb.
Journal ArticleDOI
The Breakpoint Region of the Most Common Isochromosome, i(17q), in Human Neoplasia Is Characterized by a Complex Genomic Architecture with Large, Palindromic, Low-Copy Repeats
Aikaterini Barbouti,Pawel Stankiewicz,Chad Nusbaum,Christina A. Cuomo,April Cook,Mattias Höglund,Bertil Johansson,Anne Hagemeijer,Sung Sup Park,Felix Mitelman,James R. Lupski,James R. Lupski,Thoas Fioretos +12 more
TL;DR: A complex genomic architecture is revealed in the i(17q) breakpoint cluster region, characterized by large ( approximately 38-49-kb), palindromic, low-copy repeats, strongly suggesting that somatic rearrangements are not random events but rather reflect susceptibilities due to the genomic structure.
Journal ArticleDOI
Massively parallel sequencing of human urinary exosome/microvesicle RNA reveals a predominance of non-coding RNA.
Kevin C. Miranda,Daniel T. Bond,Joshua Z. Levin,Xian Adiconis,Andrey Sivachenko,Carsten Russ,Dennis Brown,Chad Nusbaum,Leileata M. Russo +8 more
TL;DR: It is revealed that the entire genitourinary system may be mapped using microvesicle transcript analysis and that the majority of non-ribosomal RNA sequences contained in microvesicles is potentially functional non-coding RNA, which play an emerging role in cell regulation.
Journal ArticleDOI
Genome-wide identification and characterization of replication origins by deep sequencing
Jia Xu,Yoshimi Yanagisawa,Alexander M. Tsankov,Christopher Hart,Christopher Hart,Keita Aoki,Naveen Kommajosyula,Kathleen E. Steinmann,Kathleen E. Steinmann,James Bochicchio,Carsten Russ,Aviv Regev,Aviv Regev,Oliver J. Rando,Chad Nusbaum,Hironori Niki,Patrice M. Milos,Zhiping Weng,Nicholas Rhind +18 more
TL;DR: The sequences that specify origins are evolutionarily plastic, with low complexity nucleosome-excluding sequences functioning in S. pombe and S. octosporus, and binding sites for trans-acting nucleosomes-excluding proteins functioning inS.
Journal ArticleDOI
A YAC-based physical map of the mouse genome.
Chad Nusbaum,Donna K. Slonim,Katrina Harris,Bruce W. Birren,Robert G. Steen,Lincoln Stein,Joyce C. Miller,William F. Dietrich,Robert Nahf,Victoria E. H. Wang,Olga Merport,Andrew B. Castle,Zeeshan Husain,Gail Farino,Delphine Gray,Mechele O. Anderson,Richard Devine,Lloyd T. Horton,Wenjuan Ye,Xiaoyun Wu,Vardouhie Kouyoumjian,Irina S. Zemsteva,Yi Wu,Alville Collymore,Dorothy F. Courtney,James Tam,Matthew Cadman,Andrew R. Haynes,Christine Heuston,Tracy Marsland,Anne Southwell,Pamela Trickett,Mark A. Strivens,Mark T. Ross,Wojciech Makalowski,Yixun Xu,Yixun Xu,Mark S. Boguski,Nigel P. Carter,Paul Denny,Steve D.M. Brown,Thomas J. Hudson,Thomas J. Hudson,Eric S. Lander +43 more
TL;DR: Use of this map in addition to a newly constructed radiation hybrid (RH) map provides a comprehensive framework for mouse genomic studies, and directly facilitates positional cloning of mouse mutations by providing ready access to most of the genome.