C
Charles DeCarli
Researcher at University of California, Davis
Publications - 721
Citations - 77364
Charles DeCarli is an academic researcher from University of California, Davis. The author has contributed to research in topics: Dementia & Hyperintensity. The author has an hindex of 125, co-authored 614 publications receiving 65820 citations. Previous affiliations of Charles DeCarli include University of Southern California & French Institute of Health and Medical Research.
Papers
More filters
Journal ArticleDOI
NAD(P)H:quinone oxidoreductase activity is increased in hippocampal pyramidal neurons of patients with alzheimer’s disease
TL;DR: It is hypothesized that the expression pattern of QR is part of a neuroprotective system up-regulated in response to the AD process, and may lead to further insights into the pathogenesis and potential new avenues of treatment for AD.
Journal ArticleDOI
Subclinical cerebrovascular disease in mild cognitive impairment
José A. Luchsinger,Adam M. Brickman,Christiane Reitz,S. J. Cho,Nicole Schupf,Jennifer J. Manly,Ming-Xin Tang,Scott A. Small,Richard Mayeux,Charles DeCarli,Truman R. Brown +10 more
TL;DR: White matter hyperintensity (WMH) is more strongly related to amnestic mild cognitive impairment (MCI).
Journal ArticleDOI
Association of plasma ADMA levels with MRI markers of vascular brain injury: Framingham offspring study.
Aleksandra Pikula,Rainer H. Böger,Alexa S. Beiser,Renke Maas,Charles DeCarli,Edzard Schwedhelm,Jayandra J. Himali,Friedrich Schulze,Rhoda Au,Margaret Kelly-Hayes,Carlos S. Kase,Ramachandran S. Vasan,Philip A. Wolf,Sudha Seshadri +13 more
TL;DR: Higher plasma ADMA values were associated with an increased prevalence of SBIs, after adjustment for traditional stroke risk factors, suggesting ADMA may be a potentially useful new biomarker of subclinical vascular brain injury, which is an important correlate of vascular cognitive impairment and risk of stroke.
Journal ArticleDOI
Brain volume change and cognitive trajectories in aging.
Evan Fletcher,Brandon E. Gavett,Danielle J Harvey,Sarah E Tomaszewski Farias,John M Olichney,Laurel A. Beckett,Charles DeCarli,Dan M Mungas +7 more
TL;DR: Cognitive decline was strongly influenced by gray matter volume change and, especially, temporal lobe change, and may reflect involvement of temporal lobe structures that are critical for late life cognitive health but also are vulnerable to diseases of aging.
Journal ArticleDOI
Discriminant analysis of MRI measures as a method to determine the presence of dementia of the Alzheimer type
Charles DeCarli,Declan G. Murphy,A.Randy McIntosh,Diane Teichberg,Mark B. Schapiro,Barry Horwitz +5 more
TL;DR: Quantitative MRI and multivariate discriminant analysis showed promise in distinguishing the dementing process from healthy aging in a group of 60 subjects.