C
Charles DeCarli
Researcher at University of California, Davis
Publications - 721
Citations - 77364
Charles DeCarli is an academic researcher from University of California, Davis. The author has contributed to research in topics: Dementia & Hyperintensity. The author has an hindex of 125, co-authored 614 publications receiving 65820 citations. Previous affiliations of Charles DeCarli include University of Southern California & French Institute of Health and Medical Research.
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Journal ArticleDOI
White matter hyperintensities and CSF Alzheimer disease biomarkers in preclinical Alzheimer disease.
Anja Soldan,Corinne Pettigrew,Yuxin Zhu,Mei Cheng Wang,Abhay Moghekar,Rebecca F. Gottesman,Baljeet Singh,Oliver Martinez,Evan Fletcher,Charles DeCarli,Marilyn S. Albert +10 more
TL;DR: It is suggested that WMH primarily affect the risk of progression when CSF measures of neurodegeneration or neuronal injury are low, however, CSF biomarkers of amyloid and p-tau and WMH appear to have largely independent and nonsynergistic effects on therisk of progression to MCI.
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Localized hippocampus measures are associated with Alzheimer pathology and cognition independent of total hippocampal volume
TL;DR: Results suggest that regional measures of hippocampal atrophy provided by localized components analysis may be more sensitive than total HP volume to the effects of AD pathology burden among cognitively normal individuals and may provide information about HP regions whose deficits may have especially profound cognitive consequences throughout the AD clinical course.
Journal Article
Brain growth and cognitive improvement in children with human immunodeficiency virus-induced encephalopathy after 6 months of continuous infusion zidovudine therapy.
Charles DeCarli,L. Fugate,J. Falloon,Janie Eddy,David A. Katz,Robert P. Friedland,Stanley I. Rapoport,Pim Brouwers,Philip A. Pizzo +8 more
TL;DR: It is concluded that the cognitive improvement of HIV encephalopathy seen after 6 months of continuous infusion of ZDV is accompanied by reduction in brain atrophy and decreased CSF protein, suggesting an ameliorating effect ofZDV on the pathogenesis of AIDSEncephalopathy in children.
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Association of Physical Function with Clinical and Subclinical Brain Disease: The Framingham Offspring Study
Erica C. Camargo,Galit Weinstein,Galit Weinstein,Alexa S. Beiser,Zaldy S. Tan,Charles DeCarli,Margaret Kelly-Hayes,Carlos S. Kase,Joanne M. Murabito,Sudha Seshadri +9 more
TL;DR: Tests of walking speed and handgrip strength may serve as clinical markers of brain structure and function and may improve dementia risk prediction.
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Associations of Circulating Growth Differentiation Factor-15 and ST2 Concentrations With Subclinical Vascular Brain Injury and Incident Stroke
Charlotte Andersson,Charlotte Andersson,Sarah R. Preis,Alexa S. Beiser,Alexa S. Beiser,Charles DeCarli,Kai C. Wollert,Thomas J. Wang,Thomas J. Wang,James L. Januzzi,Ramachandran S. Vasan,Ramachandran S. Vasan,Sudha Seshadri +12 more
TL;DR: Circulating GDF-15 and sST2 are associated with subclinical brain injury and cognitive impairment, suggesting potential links between cardiac stress biomarkers and brain injury.