C
Charles DeCarli
Researcher at University of California, Davis
Publications - 721
Citations - 77364
Charles DeCarli is an academic researcher from University of California, Davis. The author has contributed to research in topics: Dementia & Hyperintensity. The author has an hindex of 125, co-authored 614 publications receiving 65820 citations. Previous affiliations of Charles DeCarli include University of Southern California & French Institute of Health and Medical Research.
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Journal ArticleDOI
An In Vivo Study of Phosphorus and Glucose Metabolism in Alzheimer's Disease Using Magnetic Resonance Spectroscopy and PET
Declan G. Murphy,Paul A. Bottomley,Judith A. Salerno,Charles DeCarli,Marc J. Mentis,Cheryl L. Grady,Diane Teichberg,Katherine R. Giacometti,Jack M. Rosenberg,Christopher J. Hardy,Mark B. Schapiro,Stanley I. Rapoport,Jeffrey R. Alger,Barry Horwitz +13 more
TL;DR: Altered high-energy phosphate levels are not a consequence of reduced glucose metabolism in DAT, and do not play a major role in the pathophysiology of the disorder, at least in whole-brain sections.
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Maximal brain size remains an important predictor of cognition in old age, independent of current brain pathology
Sarah E Tomaszewski Farias,Dan M Mungas,Bruce R Reed,Bruce R Reed,Owen Carmichael,Laurel A. Beckett,Danielle J Harvey,John M Olichney,Amanda Simmons,Charles DeCarli +9 more
TL;DR: Investigation of maximal brain development and measures of brain injury/atrophy jointly contribute to cognitive function in older people suggest maximal brain size as measured by ICV was related to semantic memory, executive function, and spatial ability independent of current brain volumes.
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Patent Foramen Ovale, Subclinical Cerebrovascular Disease and Ischemic Stroke in a Population-Based Cohort
Marco R. Di Tullio,Zhezhen Jin,Cesare Russo,Mitchell S.V. Elkind,Tatjana Rundek,Mitsuhiro Yoshita,Charles DeCarli,Clinton B. Wright,Shunichi Homma,Ralph L. Sacco +9 more
TL;DR: In this community-based cohort of stroke-free individuals over age 39, PFO was not associated with an increased risk of clinical stroke or subclinical cerebrovascular disease.
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Myelin Injury and Degraded Myelin Vesicles in Alzheimer’s Disease
Xinhua Zhan,Glen C. Jickling,Bradley P. Ander,Dazhi Liu,Boryana Stamova,Christopher Cox,Lee-Way Jin,Charles DeCarli,Frank R. Sharp +8 more
TL;DR: Brains from patients with Alzheimer's disease had significant loss of intact MBP, and an increase in degraded MBP in periventricular WM adjacent to a denuded ependymal layer, which is associated in part with vesicles particularly in perivavel WM that is adjacent to areas of ependedymal injury.
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A technique for single-channel MR brain tissue segmentation: Application to a pediatric sample
Jagath C. Rajapakse,Jay N. Giedd,Charles DeCarli,John Snell,Alan C. McLaughlin,Yolanda C. Vauss,Amy L. Krain,Susan D. Hamburger,Judith L. Rapoport +8 more
TL;DR: Segmentation of MR brain scans of 105 healthy children and adolescents showed that although the total brain volume was stable over age 4-18, white matter increased and gray matter decreased significantly, and white matter volume increased the most in superior and posterior regions and laterality effects were seen in hemisphere tissue volumes.