C
Charles DeCarli
Researcher at University of California, Davis
Publications - 721
Citations - 77364
Charles DeCarli is an academic researcher from University of California, Davis. The author has contributed to research in topics: Dementia & Hyperintensity. The author has an hindex of 125, co-authored 614 publications receiving 65820 citations. Previous affiliations of Charles DeCarli include University of Southern California & French Institute of Health and Medical Research.
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Journal ArticleDOI
White Matter Hyperintensities and Subclinical Infarction: Associations With Psychomotor Speed and Cognitive Flexibility
Clinton B. Wright,Joanne R. Festa,Myunghee Cho Paik,Alexis Schmiedigen,Truman R. Brown,Mitsuhiro Yoshita,Mitsuhiro Yoshita,Charles DeCarli,Charles DeCarli,Ralph L. Sacco,Yaakov Stern +10 more
TL;DR: Both SI and WMHV were associated with globally worse cognitive performance, and considering performance on the tests of sequencing, cognitive flexibility, and sensorimotor ability simultaneously using GEE,WMHV and subclinical infarction were each associated with better cognitive performance globally.
Journal ArticleDOI
Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.
Adam C. Naj,Gyungah Jun,Christiane Reitz,Brian W. Kunkle,William Perry,YoSon Park,Gary W. Beecham,Gary W. Beecham,Ruchita Rajbhandary,Kara L. Hamilton-Nelson,Li-San Wang,John S. K. Kauwe,Matthew J. Huentelman,Amanda J. Myers,Thomas D. Bird,Thomas D. Bird,Bradley F. Boeve,Clinton T. Baldwin,Gail P. Jarvik,Paul K. Crane,Ekaterina Rogaeva,M. Michael Barmada,F. Yesim Demirci,Carlos Cruchaga,Patricia L. Kramer,Nilufer Ertekin-Taner,John Hardy,Neill R. Graff-Radford,Robert C. Green,Eric B. Larson,Eric B. Larson,Peter St George-Hyslop,Peter St George-Hyslop,Joseph D. Buxbaum,Denis A. Evans,Julie A. Schneider,Kathryn L. Lunetta,M. Ilyas Kamboh,Andrew J. Saykin,Eric M. Reiman,Philip L. De Jager,Philip L. De Jager,David A. Bennett,John C. Morris,Thomas J. Montine,Alison Goate,Deborah Blacker,Debby W. Tsuang,Debby W. Tsuang,Hakon Hakonarson,Walter A. Kukull,Tatiana Foroud,Eden R. Martin,Eden R. Martin,Jonathan L. Haines,Richard Mayeux,Lindsay A. Farrer,Gerard D. Schellenberg,Margaret A. Pericak-Vance,Margaret A. Pericak-Vance,Marilyn S. Albert,Roger L. Albin,Liana G. Apostolova,Steven E. Arnold,Robert Barber,Lisa L. Barnes,Thomas G. Beach,James T. Becker,Duane Beekly,Eileen H. Bigio,James D. Bowen,Adam L. Boxer,James R. Burke,Nigel J. Cairns,Laura B. Cantwell,Chuanhai Cao,Christopher S. Carlson,Regina M. Carney,Minerva M. Carrasquillo,Steven L. Carroll,Helena C. Chui,David G. Clark,Jason J. Corneveaux,David H. Cribbs,Elizabeth Crocco,Charles DeCarli,Steven T. DeKosky,Malcolm B. Dick,Dennis W. Dickson,Ranjan Duara,Kelley Faber,Kenneth B. Fallon,Martin R. Farlow,Steven H. Ferris,Matthew P. Frosch,Douglas Galasko,Mary Ganguli,Marla Gearing,Daniel H. Geschwind,Bernardino Ghetti,John R. Gilbert,Jonathan D. Glass,Jonathan D. Glass,John H. Growdon,Ronald L. Hamilton,Lindy E. Harrell,Elizabeth Head,Lawrence S. Honig,Christine M. Hulette,Bradley T. Hyman,Gregory A. Jicha,Lee-Way Jin,Anna Karydas,Jeffrey Kaye,R. C. Kim,R. C. Kim,Edward H. Koo,Neil W. Kowall,Joel H. Kramer,Frank M. LaFerla,James J. Lah,James B. Leverenz,Allan I. Levey,Ge Li,Andrew P. Lieberman,Chiao-Feng Lin,Oscar L. Lopez,Constantine G. Lyketsos,Wendy J. Mack,Frank Martiniuk,Deborah C. Mash,Eliezer Masliah,Wayne C. McCormick,Susan M. McCurry,Andrew McDavid,Ann C. McKee,M.-Marsel Mesulam,Bruce L. Miller,Carol A. Miller,Joshua W. Miller,Jill R. Murrell,John M Olichney,Vernon S. Pankratz,Joseph E. Parisi,Henry L. Paulson,Elaine R. Peskind,Ronald C. Petersen,Aimee Pierce,Wayne W. Poon,Huntington Potter,Joseph F. Quinn,Ashok Raj,Murray A. Raskind,Barry Reisberg,John M. Ringman,Erik D. Roberson,Howard J. Rosen,Roger N. Rosenberg,Mary Sano,Lon S. Schneider,William W. Seeley,Amanda Smith,Joshua A. Sonnen,Salvatore Spina,Robert S. Stern,Rudolph E. Tanzi,Tricia A. Thornton-Wells,John Q. Trojanowski,Juan C. Troncoso,Otto Valladares,Vivianna M. Van Deerlin,Linda J. Van Eldik,Badri N. Vardarajan,Harry V. Vinters,Jean Paul Vonsattel,Sandra Weintraub,Kathleen A. Welsh-Bohmer,Jennifer Williamson,Sarah Wishnek,Randall L. Woltjer,Clinton B. Wright,Steven G. Younkin,Chang En Yu,Lei Yu +183 more
TL;DR: The combined effects of Alzheimer disease risk variants on AAO are on the scale of, but do not exceed, the APOE effect, and additional genetic contributions toAAO are individually likely to be small.
Journal ArticleDOI
Genetic architecture of subcortical brain structures in 38,851 individuals
Claudia L. Satizabal,Claudia L. Satizabal,Claudia L. Satizabal,Hieab H.H. Adams,Derrek P. Hibar,Charles C. White,Charles C. White,Maria J. Knol,Jason L. Stein,Jason L. Stein,Markus Scholz,Muralidharan Sargurupremraj,Neda Jahanshad,Gennady V. Roshchupkin,Albert V. Smith,Albert V. Smith,Joshua C. Bis,Xueqiu Jian,Michelle Luciano,Edith Hofer,Alexander Teumer,Sven J. van der Lee,Jingyun Yang,Lisa R. Yanek,Tom V. Lee,Shuo Li,Yanhui Hu,Jia Yu Koh,John D. Eicher,Sylvane Desrivières,Alejandro Arias-Vasquez,Ganesh Chauhan,Ganesh Chauhan,Lavinia Athanasiu,Lavinia Athanasiu,Miguel E. Rentería,Sungeun Kim,D. Hoehn,Nicola J. Armstrong,Qiang Chen,Avram J. Holmes,Avram J. Holmes,Anouk den Braber,Iwona Kłoszewska,Micael Andersson,Thomas Espeseth,Thomas Espeseth,Oliver Grimm,Lucija Abramovic,Saud Alhusaini,Saud Alhusaini,Yuri Milaneschi,Martina Papmeyer,Martina Papmeyer,Tomas Axelsson,Stefan Ehrlich,Stefan Ehrlich,Roberto Roiz-Santiañez,Bernd Kraemer,Asta Håberg,Hannah J. Jones,Hannah J. Jones,G. Bruce Pike,Dan J. Stein,Dan J. Stein,Allison Stevens,Janita Bralten,Meike W. Vernooij,Tamara B. Harris,Irina Filippi,A. Veronica Witte,A. Veronica Witte,Tulio Guadalupe,Katharina Wittfeld,Katharina Wittfeld,Thomas H. Mosley,James T. Becker,Nhat Trung Doan,Saskia P. Hagenaars,Yasaman Saba,Gabriel Cuellar-Partida,Najaf Amin,Saima Hilal,Saima Hilal,Kwangsik Nho,Nazanin Mirza-Schreiber,Konstantinos Arfanakis,Konstantinos Arfanakis,Diane M. Becker,David Ames,David Ames,Aaron Goldman,Phil Lee,Phil Lee,Dorret I. Boomsma,Dorret I. Boomsma,Simon Lovestone,Simon Lovestone,Sudheer Giddaluru,Sudheer Giddaluru,Stephanie Le Hellard,Stephanie Le Hellard,Manuel Mattheisen,Marc M. Bohlken,Dalia Kasperaviciute,Lianne Schmaal,Stephen M. Lawrie,Ingrid Agartz,Ingrid Agartz,Esther Walton,Esther Walton,Diana Tordesillas-Gutiérrez,Gareth E. Davies,Jean Shin,Jonathan C Ipser,Louis N. Vinke,Martine Hoogman,Tianye Jia,Ralph Burkhardt,Ralph Burkhardt,Marieke Klein,Fabrice Crivello,Deborah Janowitz,Owen Carmichael,Unn K. Haukvik,Unn K. Haukvik,Benjamin S. Aribisala,Benjamin S. Aribisala,Helena Schmidt,Lachlan T. Strike,Lachlan T. Strike,Ching-Yu Cheng,Shannon L. Risacher,Benno Pütz,Debra A. Fleischman,Amelia A. Assareh,Venkata S. Mattay,Randy L. Buckner,Patrizia Mecocci,Anders M. Dale,Sven Cichon,Sven Cichon,Marco P. Boks,Mar Matarin,Brenda W.J.H. Penninx,Vince D. Calhoun,Vince D. Calhoun,Vince D. Calhoun,M. Mallar Chakravarty,M. Mallar Chakravarty,Andre F. Marquand,Christine Macare,Shahrzad Kharabian Masouleh,Jaap Oosterlaan,Jaap Oosterlaan,Philippe Amouyel,Philippe Amouyel,Philippe Amouyel,Katrin Hegenscheid,Jerome I. Rotter,Andrew J. Schork,David C. Liewald,Greig I. de Zubicaray,Tien Yin Wong,Tien Yin Wong,Li Shen,Philipp G. Sämann,Henry Brodaty,Joshua L. Roffman,Eco J. C. de Geus,Eco J. C. de Geus,Magda Tsolaki,Susanne Erk,Kristel R. van Eijk,Gianpiero L. Cavalleri,Nic J.A. van der Wee,Andrew M. McIntosh,Randy L. Gollub,Kazima B. Bulayeva,Manon Bernard,Jennifer S. Richards,Jennifer S. Richards,Jayandra J. Himali,Jayandra J. Himali,Markus Loeffler,Nanda Rommelse,Wolfgang Hoffmann,Wolfgang Hoffmann,Lars T. Westlye,Lars T. Westlye,Maria C. Valdés Hernández,Narelle K. Hansell,Narelle K. Hansell,Theo G.M. van Erp,Christiane Wolf,John B.J. Kwok,John B.J. Kwok,John B.J. Kwok,Bruno Vellas,Andreas Heinz,Loes M. Olde Loohuis,Norman Delanty,Norman Delanty,Beng-Choon Ho,Christopher R.K. Ching,Christopher R.K. Ching,Elena Shumskaya,Baljeet Singh,Albert Hofman,Albert Hofman,Dennis van der Meer,Dennis van der Meer,Georg Homuth,Bruce M. Psaty,Mark E. Bastin,Grant W. Montgomery,Tatiana Foroud,Simone Reppermund,Jouke-Jan Hottenga,Jouke-Jan Hottenga,Andrew Simmons,Andrew Simmons,Andreas Meyer-Lindenberg,Wiepke Cahn,Christopher D. Whelan,Christopher D. Whelan,Marjolein M.J. van Donkelaar,Qiong Yang,Norbert Hosten,Robert C. Green,Anbupalam Thalamuthu,Sebastian Mohnke,Hilleke E. Hulshoff Pol,Honghuang Lin,Honghuang Lin,Clifford R. Jack,Peter R. Schofield,Peter R. Schofield,Thomas W. Mühleisen,Thomas W. Mühleisen,Pauline Maillard,Steven G. Potkin,Wei Wen,Evan Fletcher,Arthur W. Toga,Oliver Gruber,Matthew J. Huentelman,George Davey Smith,Lenore J. Launer,Lars Nyberg,Erik G. Jönsson,Erik G. Jönsson,Benedicto Crespo-Facorro,Nastassja Koen,Nastassja Koen,Douglas N. Greve,André G. Uitterlinden,Daniel R. Weinberger,Vidar M. Steen,Vidar M. Steen,Iryna O. Fedko,Iryna O. Fedko,Nynke A. Groenewold,Wiro J. Niessen,Wiro J. Niessen,Roberto Toro,Christophe Tzourio,William T. Longstreth,M. Kamran Ikram,Jordan W. Smoller,Jordan W. Smoller,Marie-José van Tol,Jessika E. Sussmann,Tomáš Paus,Herve Lemaitre,Matthias L. Schroeter,Matthias L. Schroeter,Bernard Mazoyer,Ole A. Andreassen,Ole A. Andreassen,Florian Holsboer,Chantal Depondt,Dick J. Veltman,Jessica A. Turner,Jessica A. Turner,Zdenka Pausova,Gunter Schumann,Daan van Rooij,Daan van Rooij,Srdjan Djurovic,Srdjan Djurovic,Ian J. Deary,Katie L. McMahon,Bertram Müller-Myhsok,Bertram Müller-Myhsok,Rachel M. Brouwer,Hilkka Soininen,Massimo Pandolfo,Thomas H. Wassink,Joshua W. Cheung,Thomas Wolfers,Jean-Luc Martinot,Marcel P. Zwiers,Matthias Nauck,Ingrid Melle,Ingrid Melle,Nicholas G. Martin,Ryota Kanai,Ryota Kanai,Eric Westman,René S. Kahn,René S. Kahn,Sanjay M. Sisodiya,Tonya White,Arvin Saremi,Hans van Bokhoven,Han G. Brunner,Han G. Brunner,Henry Völzke,Margaret J. Wright,Dennis van 't Ent,Dennis van 't Ent,Markus M. Nöthen,Roel A. Ophoff,Roel A. Ophoff,Jan K. Buitelaar,Guillén Fernández,Perminder S. Sachdev,Marcella Rietschel,Neeltje E.M. van Haren,Neeltje E.M. van Haren,Simon E. Fisher,Simon E. Fisher,Alexa S. Beiser,Alexa S. Beiser,Clyde Francks,Clyde Francks,Andrew J. Saykin,Karen A. Mather,Karen A. Mather,Nina Romanczuk-Seiferth,Catharina A. Hartman,Anita L. DeStefano,Anita L. DeStefano,Dirk J. Heslenfeld,Michael W. Weiner,Henrik Walter,Pieter J. Hoekstra,Paul A. Nyquist,Barbara Franke,David A. Bennett,Hans J. Grabe,Hans J. Grabe,Andrew D. Johnson,Christopher Chen,Christopher Chen,Cornelia M. van Duijn,Cornelia M. van Duijn,Oscar L. Lopez,Myriam Fornage,Joanna M. Wardlaw,Reinhold Schmidt,Charles DeCarli,Philip L. De Jager,Philip L. De Jager,Arno Villringer,Arno Villringer,Stéphanie Debette,Stéphanie Debette,Vilmundur Gudnason,Sarah E. Medland,Joshua M. Shulman,Paul M. Thompson,Sudha Seshadri,Sudha Seshadri,M. Arfan Ikram +375 more
TL;DR: This paper identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank.
Journal ArticleDOI
Rate of progression differs in frontotemporal dementia and Alzheimer disease
Katya Rascovsky,David P. Salmon,Allan Lipton,James B. Leverenz,Charles DeCarli,William J. Jagust,C. Clark,Mario F. Mendez,David F. Tang-Wai,Neil Graff-Radford,Douglas Galasko +10 more
TL;DR: The results are consistent with shorter survival and faster rates of cognitive and functional decline in patients with frontotemporal dementia (FTD) compared to those with Alzheimer disease (AD), suggesting that FTD follows a more malignant disease course than AD once dementia is clinically recognized.
Journal ArticleDOI
The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: Evidence of validity
Giovanni B. Frisoni,Clifford R. Jack,Martina Bocchetta,Corinna M. Bauer,Kristian Steen Frederiksen,Yawu Liu,Gregory M. Preboske,Tim Swihart,Melanie Blair,Enrica Cavedo,Michel J. Grothe,Mariangela Lanfredi,Oliver Martinez,Masami Nishikawa,Marileen Portegies,Travis R. Stoub,Chadwich Ward,Liana G. Apostolova,Rossana Ganzola,Dominik Wolf,Frederik Barkhof,George Bartzokis,Charles DeCarli,John G. Csernansky,Leyla deToledo-Morrell,Mirjam I. Geerlings,Jeffrey Kaye,Ronald J. Killiany,Stéphane Lehéricy,Hiroshi Matsuda,John T. O'Brien,Lisa C. Silbert,Philip Scheltens,Hilkka Soininen,Stefan J. Teipel,Stefan J. Teipel,Gunhild Waldemar,Andreas Fellgiebel,Josephine Barnes,Michael J. Firbank,Lotte Gerritsen,Lotte Gerritsen,Wouter J.P. Henneman,Nikolai Malykhin,Jens C. Pruessner,Lei Wang,Craig Watson,Henrike Wolf,Henrike Wolf,Mony deLeon,Johannes Pantel,Clarissa Ferrari,Paolo Bosco,Patrizio Pasqualetti,Simon Duchesne,Henri Duvernoy,Marina Boccardi +56 more
TL;DR: In this article, a harmonized protocol (HarP) was defined for the manual segmentation of the hippocampus on MR images and the results showed that the HarP has high measurement stability compared with local segmentation protocols, and good reproducibility within and among human tracers.