Charles DeCarli

TL;DR: Heterogeneity in the Hispanic population is hypothesized to be due, in part, to ancestry‐specific genetic effects of APOE alleles, which are the strongest known genetic predictors for AD.

TL;DR: This work hypothesized that ADNI mild cognitive impairment (MCI) subjects would also exhibit heterogeneity with possible clinical implications, and examined normal controls from the Alzheimer's Disease Neuroimaging Initiative to identify this heterogeneity.

TL;DR: The authors used biomarkers to study Vietnam Veterans with or without mild cognitive impairment with a history of at least one traumatic brain injury and/or ongoing PTSD to determine whether these contribute to the development of Alzheimer's disease.

TL;DR: In this article , the authors evaluated select preanalytic variables including magnification, compression rate, and storage format using three digital slides scanners (Zeiss Axioscan Z1, Leica Aperio AT2, and Leica A perio GT 450) on over 60 whole slide images, in a cohort of 14 cases having a spectrum of amyloid-β deposits.

TL;DR: In the community-based, stroke-free middle-aged sample, elevated BDNF has a subtle, positive effect on WM microstructural integrity in specific tracts whose integrity was also found to be associated with preserved executive function, which can expand the understanding of the structural pathways in the brain implicated in BDNF mediated preservation of cognitive reserve and protection from vascular brain injury.