C
Charles DeCarli
Researcher at University of California, Davis
Publications - 721
Citations - 77364
Charles DeCarli is an academic researcher from University of California, Davis. The author has contributed to research in topics: Dementia & Hyperintensity. The author has an hindex of 125, co-authored 614 publications receiving 65820 citations. Previous affiliations of Charles DeCarli include University of Southern California & French Institute of Health and Medical Research.
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Education attenuates the effect of medial temporal lobe atrophy on cognitive function in Alzheimer's disease: the MIRAGE study.
Robert Perneczky,Stefan Wagenpfeil,Kathryn L. Lunetta,L. Adrienne Cupples,Robert C. Green,Charles DeCarli,Lindsay A. Farrer,Alexander Kurz +7 more
TL;DR: The interaction term between education and MTA was significant suggesting that education modifies the relation of MTA to cognition, and at any level of pathology, cognition remained higher for better educated individuals.
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Managing and analysing data from a large-scale study on Framingham Offspring relating brain structure to cognitive function
Joseph M. Massaro,Ralph B. D'Agostino,Lisa M. Sullivan,Alexa S. Beiser,Charles DeCarli,Rhoda Au,Merrill F. Elias,Philip A. Wolf +7 more
TL;DR: The Framingham Heart Study is gathering brain structure and cognitive information on the Framingham Offspring, creating one of the largest known data sets to assess changes in brain structure associated with normative ageing and cognitive decline.
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Vascular dementia: emerging trends.
TL;DR: Patients with vascular dementia often exhibit mood and behavioral changes and may have focal neurological signs on neurological examination, and primary treatment is through primary or secondary modification of cerebrovascular risk factors, although symptomatic treatments with cholinesterase inhibitors have shown modest symptomatic benefit.
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Distinctive RNA expression profiles in blood associated with Alzheimer disease after accounting for white matter hyperintensities.
Zhouxian Bai,Boryana Stamova,Huichun Xu,Huichun Xu,Bradley P. Ander,Jiajia Wang,Glen C. Jickling,Xinhua Zhan,Dazhi Liu,Guangchun Han,Lee-Way Jin,Charles DeCarli,Hongxing Lei,Frank R. Sharp +13 more
TL;DR: RNA expression is altered in AD blood irrespective of white matter hyperintensities status, and some genes are shared with AD brain.
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Alcohol intake and brain structure in a multiethnic elderly cohort
Yian Gu,Nikolaos Scarmeas,Erica Eaton Short,José A. Luchsinger,Charles DeCarli,Yaakov Stern,Jennifer J. Manly,Nicole Schupf,Richard Mayeux,Adam M. Brickman +9 more
TL;DR: It is suggested that among older adults in the community, light-to-moderate alcohol intake, in particular wine, is associated with larger TBV, and light to moderate alcohol consumption is potentially beneficial for brain aging.