C
Charles DeCarli
Researcher at University of California, Davis
Publications - 721
Citations - 77364
Charles DeCarli is an academic researcher from University of California, Davis. The author has contributed to research in topics: Dementia & Hyperintensity. The author has an hindex of 125, co-authored 614 publications receiving 65820 citations. Previous affiliations of Charles DeCarli include University of Southern California & French Institute of Health and Medical Research.
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Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants
Vincent Damotte,Sven J. van der Lee,Sven J. van der Lee,Vincent Chouraki,Vincent Chouraki,Benjamin Grenier-Boley,Jeannette Simino,Hieab H.H. Adams,Giuseppe Tosto,Charles C. White,Charles C. White,Natalie Terzikhan,Natalie Terzikhan,Carlos Cruchaga,Maria J. Knol,Shuo Li,Susanna Schraen,Megan L. Grove,Claudia L. Satizabal,Najaf Amin,Claudine Berr,Steven G. Younkin,Alzheimer’s Disease Neuroimaging Initiative,Rebecca F. Gottesman,Rebecca F. Gottesman,Luc Buée,Luc Buée,Alexa S. Beiser,David S. Knopman,André G. Uitterlinden,Charles DeCarli,Jan Bressler,Anita L. DeStefano,Jean-François Dartigues,Qiong Yang,Eric Boerwinkle,Eric Boerwinkle,Christophe Tzourio,Myriam Fornage,M. Arfan Ikram,Philippe Amouyel,Phil de Jager,Phil de Jager,Phil de Jager,Christiane Reitz,Thomas H. Mosley,Jean-Charles Lambert,Sudha Seshadri,Sudha Seshadri,Cornelia M. van Duijn,Cornelia M. van Duijn +50 more
TL;DR: In this article, the authors identified associations across APOE for Aβ1-42 and Aβ 1-42/Aβ 1 -40 ratio, and BACE1 for A β 1-40 ratio.
Journal Article
Abstract W P246: Diagnostic Value of Lobar Hemorrhages for Cerebral Amyloid Angiopathy in Hospital and Community-based Individuals: A Pathological Correlation Study
Sergi Martinez-Ramirez,Jose-Rafael Romero,M. Edip Gurol,Shoamanesh Ashkan,Ann C. McKee,Ellis S. van Etten,Octavio M. Pontes-Neto,Alison M. Ayres,Eitan Auriel,Jayandra J. Himali,Alexa S. Beiser,Charles DeCarli,Thor D. Stein,Victor E. Alvarez,Matthew P. Frosch,Jonathan Rosand,Steven M. Greenberg,Sudha Seshadri,Anand Viswanathan +18 more
TL;DR: Specificity of detection of multiple lobar hemorrhages on MRI (“probable CAA”) for moderate-severe CAA is similarly high in both hospital and community cohorts, increasing the opportunity to identify individuals with CAA for observational studies and emerging anti-amyloid therapeutic trials.
Journal ArticleDOI
Shanghai community brain health initiative: Pilot study. Neuropsychological results
Qianhua Zhao,Ding Ding,Qihao Guo,James A. Mortimer,Cathleen Copenhaver,David P. Salmon,Douglas Galasko,Charles DeCarli,Qi Dai,R. C. Petersen,Yougui Wu,Zhen Hong,Amy R. Borenstein +12 more
TL;DR: Lower cognitive reserve, as determined by education level and IQ, in the QH group may reflect an increased risk for conversion to MCI at the 18-month follow-up assessment, suggesting bimodality in healthy ageing.
Journal Article
PRE-CELL: Clinical and Novel Biomarker Measures of Disease Progression in a Lead-In-Observational Study for a Planned Phase 1 Trial of Genetically-Modified Mesenchymal Stem Cells Over-Expressing BDNF in Patients with Huntington’s Disease (S25.004)
Vicki L. Wheelock,Teresa Tempkin,Alexandra Duffy,Amanda Martin,Lisa Mooney,Ashok Dayananthan,Lorin M Scher,Sarah E Tomaszewski Farias,David Swadell,Charles DeCarli,James A. Brunberg,Chin-Shang Li,Yu Liu,Mark A Yarborough,Julie C. Stout,Miriam Moscovitch-Lopatin,Steven M. Hersch,Kyle D. Fink,Geralyn Annett,Jan A. Nolta +19 more
TL;DR: The PRE-CELL study has enrolled a cohort of subjects with early-stage HD and has characterized the rate of change in clinical, imaging and novel serum and CSF biomarker measures, and shows significant reduction in striatal volume detected at 6 months.
Journal ArticleDOI
Fornix white matter degeneration is a sensitive indicator of both early and late cognitive decline in a diverse community cohort
TL;DR: Fieremans et al. as mentioned in this paper performed a 3T Trio MR system (Siemens), providing parametric maps of the diffusion metrics, including WMTI maps for D axon, AWF, D e,axial, and D e,radial 1,2.