C
Charles E. Alpers
Researcher at University of Washington
Publications - 418
Citations - 35650
Charles E. Alpers is an academic researcher from University of Washington. The author has contributed to research in topics: Renal pathology & Glomerulonephritis. The author has an hindex of 89, co-authored 409 publications receiving 32440 citations. Previous affiliations of Charles E. Alpers include New York Medical College & University of Washington Medical Center.
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Journal ArticleDOI
The Classification of Glomerulonephritis in Systemic Lupus Erythematosus Revisited
Jan J. Weening,Vivette D. D'Agati,Melvin M. Schwartz,Surya V. Seshan,Charles E. Alpers,Gerald B. Appel,James E. Balow,Jan A. Bruijn,Terence Cook,Franco Ferrario,Agnes B. Fogo,Ellen M. Ginzler,Lee A. Hebert,Gary Hill,Prue Hill,J. Charles Jennette,Norella C T Kong,Philippe Lesavre,Michael D. Lockshin,Lai-Meng Looi,Hirofumi Makino,Luiz Antonio Ribeiro de Moura,Michio Nagata +22 more
TL;DR: The main advantages of the current revised classification is that it provides a clear and unequivocal description of the various lesions and classes of lupus nephritis, allowing a better standardization and lending a basis for further clinicopathologic studies.
Journal ArticleDOI
The classification of glomerulonephritis in systemic lupus erythematosus revisited
Jan J. Weening,Vivette D. D'Agati,Melvin M. Schwartz,Surya V. Seshan,Charles E. Alpers,Gerald B. Appel,James E. Balow,Jan A. Bruijn,Terence Cook,Franco Ferrario,Agnes B. Fogo,Ellen M. Ginzler,Lee A. Hebert,Gary Hill,Prue Hill,J. Charles Jennette,Norella C T Kong,Philippe Lesavre,Michael D. Lockshin,Lai-Meng Looi,Hirofumi Makino,Luiz Antonio Ribeiro de Moura,Michio Nagata +22 more
TL;DR: The main advantages of the current revised classification is that it provides a clear and unequivocal description of the various lesions and classes of lupus nephritis, allowing a better standardization and lending a basis for further clinicopathologic studies.
Journal ArticleDOI
VEGF inhibition and renal thrombotic microangiopathy.
Vera Eremina,J. Ashley Jefferson,Jolanta Kowalewska,Howard S. Hochster,Mark Haas,Joseph Weisstuch,Catherine A. Richardson,Jeffrey B. Kopp,M. Golam Kabir,Peter H. Backx,Hans-Peter Gerber,Napoleone Ferrara,Laura Barisoni,Charles E. Alpers,Susan E. Quaggin +14 more
TL;DR: To show that local reduction of VEGF within the kidney is sufficient to trigger the pathogenesis of thrombotic microangiopathy, this work used conditional gene targeting to delete V EGF from renal podocytes in adult mice and resulted in a profound thromBotic glomerular injury.
Journal ArticleDOI
The Oxford classification of IgA nephropathy: Rationale, clinicopathological correlations, and classification
Daniel C. Cattran,Rosanna Coppo,H. Terence Cook,John Feehally,Ian Roberts,Stéphan Troyanov,Charles E. Alpers,Alessandro Amore,Jonathan Barratt,François Berthoux,Stephen M. Bonsib,Jan A. Bruijn,Vivette D. D'Agati,Giuseppe D'Amico,Steven N. Emancipator,Francesco Emma,Franco Ferrario,Fernando C. Fervenza,Sandrine Florquin,Agnes B. Fogo,Colin C. Geddes,Hermann Josef Groene,Mark Haas,Andrew M. Herzenberg,Prue Hill,Ronald J. Hogg,Stephen I-Hong Hsu,J. Charles Jennette,Kensuke Joh,Bruce A. Julian,Tetsuya Kawamura,Fernand Mac-Moune Lai,Chi Bon Leung,Lei Shi Li,Philip Kam-Tao Li,Zhihong Liu,Bruce Mackinnon,Sergio Mezzano,F. Paolo Schena,Yasuhiko Tomino,Patrick D. Walker,Haiyan Wang,Jan J. Weening,N Yoshikawa,Hong Zhang +44 more
TL;DR: In this article, a new classification for IgA nephropathy is presented by an international consensus working group and the goal of this new system was to identify specific pathological features that more accurately predict risk of progression of renal disease.
Journal ArticleDOI
Mouse Models of Diabetic Nephropathy
Frank C. Brosius,Charles E. Alpers,Erwin P. Bottinger,Matthew D. Breyer,Thomas M. Coffman,Susan B. Gurley,Raymond C. Harris,Masao Kakoki,Matthias Kretzler,Edward H. Leiter,Moshe Levi,Richard A. McIndoe,Kumar Sharma,Oliver Smithies,Katalin Susztak,Nobuyuki Takahashi,Takamune Takahashi +16 more
TL;DR: This interim report and an online supplement detail the progress made toward a complete murine model of human diabetic kidney disease and the critical analysis of existing murine models, which substantially enhances the understanding of this disease process.