Cheng Li

TL;DR: A distinct class of miRNAs are uncovered that target nearly all cyclins/CDKs, which are very effective in inhibiting cancer cell proliferation, and highlight the utility of using cell-cycle-targeting miRNAs for treatment of refractory cancer types.

TL;DR: A familial pheochromocytoma syndrome consistent with digenic inheritance identified through a combination of global genomics strategies is described and a recessive digenic trait is added to the increasingly broad genetic heterogeneity of these tumors.

TL;DR: The JNK pathway was identified as a major barrier to chemical reprogramming, the inhibition of which was indispensable for inducing cell plasticity and a regeneration-like program by suppressing pro-inflammatory pathways and provides a platform for the generation and application of human pluripotent stem cells in biomedicine.

TL;DR: The results suggest that 2ME2 overcomes Dex resistance by modulating genes that confer chemoresistance in MM cells, and may allow improved therapeutic use of 2 ME2, based upon targeting genes that regulate MM cell growth and survival.

TL;DR: The dChip-GemiNI (Gene and miRNA Network-based Integration) method statistically ranks computationally predicted FFLs by their explanatory power to account for differential gene and miRNAs expression between two biological conditions such as normal and cancer.