C
Cheng Li
Researcher at Peking University
Publications - 238
Citations - 49764
Cheng Li is an academic researcher from Peking University. The author has contributed to research in topics: Gene & Medicine. The author has an hindex of 63, co-authored 200 publications receiving 42539 citations. Previous affiliations of Cheng Li include University of California, Los Angeles & Tongji University.
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Journal ArticleDOI
Lessons from a decade of integrating cancer copy number alterations with gene expression profiles
TL;DR: This work discusses the quantitative relationships observed between CNA and gene expression in multiple cancer types and biological milestones achieved using the available methodologies, and provides suggestions for building efficient data integration methodologies.
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Gene Expression Profile Alone Is Inadequate In Predicting Complete Response In Multiple Myeloma
Samirkumar B. Amin,Wai-Ki Yip,Stephane Minvielle,Annemiek Broyl,Yi Li,Bret Hanlon,David Swanson,Parantu K. Shah,Philippe Moreau,Bronno van der Holt,Mark van Duin,Florence Magrangeas,Pieter Sonneveld,Kenneth C. Anderson,Cheng Li,Hervé Avet-Loiseau,Nikhil C. Munshi +16 more
TL;DR: It is suggested that GEP-based signature has limited power to predict CR in MM, highlighting the need to develop comprehensive predictive model using integrated genomics approach.
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Postoperative Delirium Is Associated with Long-term Decline in Activities of Daily Living.
Zhongyong Shi,Xinchun Mei,Cheng Li,Yupeng Chen,Hailin Zheng,Yujie Wu,Hui Zheng,Liang Liu,Edward R. Marcantonio,Zhongcong Xie,Yuan Shen +10 more
TL;DR: Postoperative delirium was associated with long-term detrimental outcomes, including greater decline in activities of daily living and a higher rate of postoperative mortality.
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Temporal genetic program following B-cell receptor cross-linking: altered balance between proliferation and death in healthy and malignant B cells.
TL;DR: The molecular basis for the different functional consequences of BCR cross-linking in healthy and malignant B cells is identified and analysis of gene expression profiling over time may be used to identify genes that might be rational targets to perturb these pathways.
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Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors
Yuetong Wang,Jian Zhang,Shengxiang Ren,Dan Sun,Hsin-Yi Huang,Hua Wang,Yujuan Jin,Fuming Li,Chao Zheng,Liu Yang,Lei Deng,Zhonglin Jiang,Tao Jiang,Xiangkun Han,Shenda Hou,Chenchen Guo,Fei Li,Dong Gao,Jun Qin,Daming Gao,Luonan Chen,Shuhai Lin,Kwok-Kin Wong,Cheng Li,Liang Hu,Caicun Zhou,Hongbin Ji +26 more
TL;DR: It is found that 2-h sublethal TKI treatment elicits a transient drug-tolerant state in EGFR mutant lung cancer cells, and the importance of BCAT1-engaged metabolism reprogramming in TKI resistance in lung cancer is revealed.