Cheng Li

TL;DR: It is concluded that telomerase inhibition by PPA induces cell growth arrest in BEAC cells and demonstrates the potential of telomersase inhibitors in chemoprevention and treatment of Barrett's-associated esophageal adenocarcinoma.

TL;DR: This work unveils that nuclear actin promotes the formation of transcription factory on inducible genes, acting as a general mechanism underlying the rapid response to environmental cues.

TL;DR: The ability to identify and sequence low‐level mutations in the absence of elaborate microdissection, via COLD‐PCR‐based Sanger sequencing, provides a platform for accurate mutation profiling in clinical specimens and the use of TP53 as a prognostic/predictive biomarker, evaluation of cancer risk, recurrence, and further understanding of cancer biology.

TL;DR: NF1 null states are present in 7 of 95 (7%) of adult AML and delineate a disease subset that could be preferentially targeted by Ras or mammalian target of rapamycin–directed therapeutics.

TL;DR: In patient-derived xenograft models, digitoxin treatment efficiently inhibited lung SCC progression in correlation with reduced expression of YAP, highlighting a novel tumor-suppressor function of Y AP via downregulation of GPX2 and ROS accumulation.