Cheng Li

TL;DR: In this paper, the authors investigated hierarchical topologically associating domain (TAD) structures in cancers and defined a "TAD hierarchical score (TH score)" for genes, which allowed them to assess the TAD nesting level of all genes in a simplified way.

TL;DR: Genetic changes in a cohort of 143 CLL cases analyzed longitudinally for changes in acquired genomic copy number aberrations, acquired uniparental disomy, and somatically acquired mutations in the genes TP53, SF3B1, and NOTCH1 are described.

TL;DR: This study provides a novel web server that could effectively predict the regulation of miRNAs expression by small molecules and predicted binding affinities of oncogenic mi RNAs and small molecules bore a close resemblance to the lowest binding energy profiles using molecular docking.

TL;DR: This work uncovers a novel role of nuclear actin in inducible transcriptional regulation using next-generation transcriptome sequencing and super-resolution microscopy and unveilsnuclear actin promotes the formation of transcription factory on inducable genes, acting as a general mechanism underlying the rapid response to environmental cues.

TL;DR: It is found that 2-hour sublethal TKI treatment elicits a transient drug-tolerant state in EGFR-mutant lung cancer cells and the importance of epigenetically regulated BCAT1-engaged metabolism reprogramming in TKI resistance in lung cancer is revealed.