C
Cheng S. Jin
Researcher at Princess Margaret Cancer Centre
Publications - 26
Citations - 2867
Cheng S. Jin is an academic researcher from Princess Margaret Cancer Centre. The author has contributed to research in topics: Photothermal therapy & Photodynamic therapy. The author has an hindex of 17, co-authored 26 publications receiving 2473 citations. Previous affiliations of Cheng S. Jin include University Health Network & University of Toronto.
Papers
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Journal ArticleDOI
Porphysome nanovesicles generated by porphyrin bilayers for use as multimodal biophotonic contrast agents
Jonathan F. Lovell,Cheng S. Jin,Cheng S. Jin,Elizabeth Huynh,Elizabeth Huynh,Honglin Jin,Honglin Jin,Chulhong Kim,John L. Rubinstein,Warren C. W. Chan,Weiguo Cao,Lihong V. Wang,Gang Zheng,Gang Zheng +13 more
TL;DR: The development of porphysomes; nanovesicles formed from self-assembled porphyrin bilayers that generated large, tunable extinction coefficients, structure-dependent fluorescence self-quenching and unique photothermal and photoacoustic properties demonstrate the multimodal potential of organic nanoparticles for biophotonic imaging and therapy.
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Ablation of hypoxic tumors with dose-equivalent photothermal, but not photodynamic, therapy using a nanostructured porphyrin assembly.
TL;DR: It is determined that nanostructured porphyrin PTT enhancers are advantageous to overcome hypoxic conditions to achieve effective ablation of solid tumors.
Journal ArticleDOI
In situ conversion of porphyrin microbubbles to nanoparticles for multimodality imaging
Elizabeth Huynh,Ben Y. C. Leung,Brandon Helfield,Mojdeh Shakiba,Julie-Anne Gandier,Cheng S. Jin,Emma R. Master,Brian C. Wilson,David E. Goertz,Gang Zheng +9 more
TL;DR: This work shows the conversion of microbubbles to nanoparticles using low-frequency ultrasound and shows that this conversion is possible in tumour-bearing mice and could be validated using photoacoustic imaging.
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A PEGylation-Free Biomimetic Porphyrin Nanoplatform for Personalized Cancer Theranostics.
Liyang Cui,Liyang Cui,Liyang Cui,Qiaoya Lin,Cheng S. Jin,Cheng S. Jin,Wenlei Jiang,Huang Huang,Lili Ding,Nidal Muhanna,Nidal Muhanna,Jonathan C. Irish,Jonathan C. Irish,Fan Wang,Juan Chen,Gang Zheng +15 more
TL;DR: PLP offers a biomimetic theranostic nanoplatform for pretreatment stratification using PET and NIR fluorescence imaging and for further customized cancer management via imaging-guided surgery, PDT, or/and potential chemotherapy.
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Targeting-Triggered Porphysome Nanostructure Disruption for Activatable Photodynamic Therapy
TL;DR: In both in vitro and in vivo studies, folate‐porphysomes can achieve folate receptor‐selective PDT efficacy, which proves the robustness of targeting‐triggered PDT activation of porphysome nanostructure for highly selective tumor ablation.