Journal ArticleDOI
A PEGylation-Free Biomimetic Porphyrin Nanoplatform for Personalized Cancer Theranostics.
Liyang Cui,Liyang Cui,Liyang Cui,Qiaoya Lin,Cheng S. Jin,Cheng S. Jin,Wenlei Jiang,Huang Huang,Lili Ding,Nidal Muhanna,Nidal Muhanna,Jonathan C. Irish,Jonathan C. Irish,Fan Wang,Juan Chen,Gang Zheng +15 more
TLDR
PLP offers a biomimetic theranostic nanoplatform for pretreatment stratification using PET and NIR fluorescence imaging and for further customized cancer management via imaging-guided surgery, PDT, or/and potential chemotherapy.Abstract:
PEGylation (PEG) is the most commonly adopted strategy to prolong nanoparticles’ vascular circulation by mitigating the reticuloendothelial system uptake. However, there remain many concerns in regards to its immunogenicity, targeting efficiency, etc., which inspires pursuit of alternate, non-PEGylated systems. We introduced here a PEG-free, porphyrin-based ultrasmall nanostructure mimicking nature lipoproteins, termed PLP, that integrates multiple imaging and therapeutic functionalities, including positron emission tomography (PET) imaging, near-infrared (NIR) fluorescence imaging and photodynamic therapy (PDT). With an engineered lipoprotein-mimicking structure, PLP is highly stable in the blood circulation, resulting in favorable pharmacokinetics and biodistribution without the need of PEG. The prompt tumor intracellular trafficking of PLP allows for rapid nanostructure dissociation upon tumor accumulation to release monomeric porphyrins to efficiently generate fluorescence and photodynamic reactivity,...read more
Citations
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Journal ArticleDOI
Molecular Interactions in Organic Nanoparticles for Phototheranostic Applications
Kenneth K. Ng,Gang Zheng +1 more
Journal ArticleDOI
Cell Membrane Coated Semiconducting Polymer Nanoparticles for Enhanced Multimodal Cancer Phototheranostics
TL;DR: An organic phototheranostic system that biomimetically targets the component in the tumor microenvironment for enhanced multimodal cancer theranostics and generates enhanced cytotoxic heat and singlet oxygen to exert combinational photothermal and photodynamic therapy, leading to an antitumor efficacy higher than that of the counterparts.
Journal ArticleDOI
Intracellularly Acid-Switchable Multifunctional Micelles for Combinational Photo/Chemotherapy of the Drug-Resistant Tumor.
Tingting Wang,Dangge Wang,Haijun Yu,Mingwei Wang,Jianping Liu,Bing Feng,Fangyuan Zhou,Qi Yin,Zhiwen Zhang,Yongzhuo Huang,Yaping Li +10 more
TL;DR: This study presents a robust nanoplatform for multimodal imaging and combinational therapy of the drug-resistant tumor, which might provide an insight for developing polymer-based NDDS for cancer therapy.
Journal ArticleDOI
Elimination of established tumors with nanodisc-based combination chemoimmunotherapy
TL;DR: This work provides a new, generalizable framework for using nanoparticle-based chemotherapy to initiate antitumor immunity and sensitize tumors to immune checkpoint blockade.
Journal ArticleDOI
High-Density Lipoproteins: Nature’s Multifunctional Nanoparticles
TL;DR: Clinical pharmacokinetics and safety of reconstituted HDL products, comparison of HDL with inorganic and other organic nanoparticles, and intrinsic targeting properties to different recipient cells are summarized.
References
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Journal ArticleDOI
Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size
Horacio Cabral,Yu Matsumoto,Kazue Mizuno,Qixian Chen,Mami Murakami,M. Kimura,Yasuko Terada,Mitsunobu R. Kano,Kohei Miyazono,Mitsuru Uesaka,Nobuhiro Nishiyama,Kazunori Kataoka +11 more
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