C
Constantine J. Karvellas
Researcher at University of Alberta
Publications - 167
Citations - 5634
Constantine J. Karvellas is an academic researcher from University of Alberta. The author has contributed to research in topics: Liver transplantation & Medicine. The author has an hindex of 35, co-authored 136 publications receiving 4325 citations. Previous affiliations of Constantine J. Karvellas include University of Cambridge & King's College.
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Journal ArticleDOI
A comparison of early versus late initiation of renal replacement therapy in critically ill patients with acute kidney injury: a systematic review and meta-analysis
Constantine J. Karvellas,Maha R. Farhat,Imran Sajjad,Simon S Mogensen,Alexander A. Leung,Ron Wald,Sean M. Bagshaw +6 more
TL;DR: Earlier institution of RRT in critically ill patients with AKI may have a beneficial impact on survival, however, this conclusion is based on heterogeneous studies of variable quality and only two randomised trials.
Journal ArticleDOI
Arterial ammonia and clinical risk factors for encephalopathy and intracranial hypertension in acute liver failure
William Bernal,Catherine Hall,Constantine J. Karvellas,Georg Auzinger,Elizabeth Sizer,Julia Wendon +5 more
TL;DR: Ammonia is an independent risk factor for the development of both HE and ICH, and its combination with ammonia increased specificity and accuracy and improved the prediction of HE.
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Effects of fractionated plasma separation and adsorption on survival in patients with acute-on-chronic liver failure
Andreas Kribben,Guido Gerken,Sebastian Haag,Stefan Herget–Rosenthal,Ulrich Treichel,Christoph Betz,Christoph Sarrazin,Eric Hoste,Hans Van Vlierberghe,Angels Escorsell,Carsten Hafer,Oliver Schreiner,Peter R. Galle,Elena Mancini,Paolo Caraceni,Constantine J. Karvellas,Hermann Salmhofer,Mladen Knotek,Pere Ginès,Justyna Kozik–Jaromin,Kinan Rifai +20 more
TL;DR: Among all patients with AOCLF, extracorporeal liver support with FPSA does not increase the probability of survival, and further studies are needed to assess whether therapy might be beneficial in specific subsets of patients.
Journal ArticleDOI
Outcomes in adults with acute liver failure between 1998 and 2013: An observational cohort study
Adrian Reuben,Holly Tillman,Robert J. Fontana,Timothy Davern,Brendan M. McGuire,R. Todd Stravitz,Valerie Durkalski,Anne M. Larson,Iris Liou,Oren K. Fix,Michael L. Schilsky,Timothy M. McCashland,J. Eileen Hay,Natalie Murray,Obaid S. Shaikh,Daniel Ganger,Atif Zaman,Steven B. Han,Raymond T. Chung,Alastair D. Smith,Robert S. Brown,Jeffrey S. Crippin,M. Edwyn Harrison,David G. Koch,Santiago Munoz,K. Rajender Reddy,Lorenzo Rossaro,Raj Satyanarayana,Tarek Hassanein,A. James Hanje,Jody C. Olson,Ram Subramanian,Constantine J. Karvellas,Bilal Hameed,Averell H. Sherker,Patricia R. Robuck,William M. Lee +36 more
TL;DR: This large cohort study found that despite similar causes and severity of ALF among patients referred to specialty centers from 1998 to 2013, the proportion of patients listed for liver transplantation decreased and survival improved among those who did not receive a transplant as well asThose who did.
Journal ArticleDOI
Management of the critically ill patient with cirrhosis: A multidisciplinary perspective
Mitra K. Nadim,François Durand,John A. Kellum,Josh Levitsky,Jacqueline G. O'Leary,Constantine J. Karvellas,Jasmohan S. Bajaj,Andrew Davenport,Rajiv Jalan,Paolo Angeli,Stephen H. Caldwell,Javier Fernández,Claire Francoz,Guadalupe Garcia-Tsao,Pere Ginès,Michael G. Ison,David J. Kramer,Ravindra L. Mehta,Richard Moreau,David C. Mulligan,Jody C. Olson,Elizabeth A. Pomfret,Marco Senzolo,Randolph H. Steadman,Ram M. Subramanian,Jean Louis Vincent,Yuri Genyk +26 more
TL;DR: The management of the critically ill patient with cirrhosis: A multidisciplinary perspective is presented from a multi-disciplinary perspective.