Coryse St Hillaire-Clarke

TL;DR: A comprehensive summary of the physiological and behavioral phenotypes of RTT mouse models to date and areas in which further phenotypic analyses are required to enhance the utility of these models for translational studies are summarized.

TL;DR: Interoception refers to the representation of the internal states of an organism, and includes the processes by which it senses, interprets, integrates, and regulates signals from within itself as discussed by the authors.

TL;DR: The National Institute of Neurological Disorders and Stroke has established the Parkinson's Disease Biomarkers Program to promote discovery of PD biomarkers for use in phase II and III clinical trials.

TL;DR: The new research plan is organized around both short-term and long-term goals with the expectation that progress toward specific objectives can be achieved within a five to ten year time frame.

TL;DR: The role of the PDBP in PD biomarker identification is discussed in this paper, where the authors present guidelines to facilitate their development, including harmonizing procedures for biofluid acquisition and clinical assessments, replication of the most promising biomarkers, support and encouragement of publications that report negative findings, longitudinal follow-up of current cohorts including the PDBP, testing of wearable technologies to capture readouts between study visits and development of recently diagnosed (de novo) cohorts to foster identification of the earliest markers of disease onset.