D
Daisy A. Hoagland
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 22
Citations - 5044
Daisy A. Hoagland is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 10, co-authored 17 publications receiving 2828 citations. Previous affiliations of Daisy A. Hoagland include University of Vermont.
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Journal ArticleDOI
Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.
Daniel Blanco-Melo,Benjamin E. Nilsson-Payant,Wen-Chun Liu,Skyler Uhl,Daisy A. Hoagland,Rasmus Møller,Tristan X. Jordan,Kohei Oishi,Maryline Panis,David H. Sachs,Taia T. Wang,Robert E. Schwartz,Jean K. Lim,Randy A. Albrecht,Benjamin R. tenOever +14 more
TL;DR: It is proposed that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.
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A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids.
Liuliu Yang,Yuling Han,Benjamin E. Nilsson-Payant,Vikas Gupta,Pengfei Wang,Xiaohua Duan,Xiaohua Duan,Xuming Tang,Jiajun Zhu,Zeping Zhao,Fabrice Jaffré,Tuo Zhang,Tae Wan Kim,Oliver Harschnitz,David Redmond,Sean Houghton,Chengyang Liu,Ali Naji,Gabriele Ciceri,Sudha R Guttikonda,Yaron Bram,Duc-Huy T. Nguyen,Michele Cioffi,Vasuretha Chandar,Daisy A. Hoagland,Yaoxing Huang,Jenny Xiang,Hui Wang,Hui Wang,David Lyden,Alain C. Borczuk,Huanhuan Joyce Chen,Lorenz Studer,Fong Cheng Pan,David D. Ho,Benjamin R. tenOever,Todd Evans,Robert E. Schwartz,Shuibing Chen +38 more
TL;DR: It is found that human pancreatic beta cells and liver organoids are highly permissive to SARS-CoV-2 infection, further validated using adult primary human islets and adult hepatocyte and cholangiocyte organoids.
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Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells.
Zharko Daniloski,Tristan X. Jordan,Hans-Hermann Wessels,Daisy A. Hoagland,Silva Kasela,Mateusz Legut,Silas Maniatis,Eleni P. Mimitou,Lu Lu,Evan T. Geller,Oded Danziger,Brad R. Rosenberg,Hemali Phatnani,Peter Smibert,Tuuli Lappalainen,Benjamin R. tenOever,Neville E. Sanjana +16 more
TL;DR: Overall, this work provides a genome-scale, quantitative resource of the impact of the loss of each host gene on fitness/response to viral infection.
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A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics.
Longlong Si,Haiqing Bai,Melissa Rodas,Wuji Cao,Crystal Yuri Oh,Amanda Jiang,Amanda Jiang,Rasmus Møller,Daisy A. Hoagland,Kohei Oishi,Shu Horiuchi,Skyler Uhl,Daniel Blanco-Melo,Randy A. Albrecht,Wen-Chun Liu,Tristan X. Jordan,Benjamin E. Nilsson-Payant,Ilona Golynker,Justin J. Frere,James Logue,Robert Haupt,Marisa McGrath,Stuart Weston,Tian Zhang,Roberto Plebani,Roberto Plebani,Mercy Soong,Atiq Nurani,Seongmin Kim,Danni Y. Zhu,Kambez H. Benam,Kambez H. Benam,Girija Goyal,Sarah E. Gilpin,Rachelle Prantil-Baun,Steven P. Gygi,Rani K. Powers,Kenneth E. Carlson,Matthew B. Frieman,Benjamin R. tenOever,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber +42 more
TL;DR: In this paper, a microfluidic bronchial-airway-on-a-chip line was used to model the human airway epithelium and pulmonary endothelium to model viral infection, strain-dependent virulence, cytokine production and the recruitment of circulating immune cells.
Journal ArticleDOI
Leveraging the antiviral type I interferon system as a first line of defense against SARS-CoV-2 pathogenicity.
Daisy A. Hoagland,Rasmus Møller,Skyler Uhl,Kohei Oishi,Justin J. Frere,Ilona Golynker,Shu Horiuchi,Maryline Panis,Daniel Blanco-Melo,David H. Sachs,Knarik Arkun,Jean K. Lim,Benjamin R. tenOever +12 more
TL;DR: In this paper, the authors investigated the dynamics of the systemic response to SARS-CoV-2 in hamsters by histological analysis and transcriptional profiling, and they found that the antiviral response with intranasal administration of recombinant IFN-I reduced viral disease, prevented transmission, and lowered inflammation in vivo.