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Darleen A. Sandoval
Researcher at University of Michigan
Publications - 137
Citations - 9873
Darleen A. Sandoval is an academic researcher from University of Michigan. The author has contributed to research in topics: Glucose homeostasis & Sleeve gastrectomy. The author has an hindex of 47, co-authored 137 publications receiving 8108 citations. Previous affiliations of Darleen A. Sandoval include Arizona State University & Vanderbilt University.
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Journal ArticleDOI
FXR is a molecular target for the effects of vertical sleeve gastrectomy
Karen K. Ryan,Valentina Tremaroli,Christoffer Clemmensen,Christoffer Clemmensen,Petia Kovatcheva-Datchary,Andriy Myronovych,Rebekah Karns,Hilary E. Wilson-Pérez,Darleen A. Sandoval,Rohit Kohli,Fredrik Bäckhed,Fredrik Bäckhed,Randy J. Seeley +12 more
TL;DR: It is demonstrated that the therapeutic value of VSG does not result from mechanical restriction imposed by a smaller stomach, rather, VSG is associated with increased circulating bile acids, and associated changes to gut microbial communities, which point to bile acid and FXR signalling as an important molecular underpinning for the beneficial effects of this weight-loss surgery.
Journal ArticleDOI
Glucagon-like peptide 1 (GLP-1)
Timo D. Müller,Brian Finan,Stephen R. Bloom,David A. D'Alessio,Daniel J. Drucker,Peter R. Flatt,Andreas Fritsche,Fiona M. Gribble,Harvey J. Grill,Joel F. Habener,Jens J. Holst,Wolfgang Langhans,Juris J. Meier,Michael A. Nauck,Diego Perez-Tilve,Alessandro Pocai,Frank Reimann,Darleen A. Sandoval,Thue W. Schwartz,Randy J. Seeley,Kerstin Stemmer,Mads Tang-Christensen,Stephen C. Woods,Richard D. DiMarchi,M.H. Tschöp +24 more
TL;DR: The numerous beneficial effects of GLP-1 render this hormone an interesting candidate for the development of pharmacotherapies to treat obesity, diabetes, and neurodegenerative disorders.
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A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents
Brian Finan,Bin Yang,Nickki Ottaway,David L. Smiley,Tao Ma,Christoffer Clemmensen,Joseph Chabenne,Lianshan Zhang,Kirk M. Habegger,Katrin Fischer,Jonathan E. Campbell,Darleen A. Sandoval,Randy J. Seeley,Konrad Bleicher,Sabine Uhles,William Riboulet,Jürgen Funk,Cornelia Hertel,Sara Belli,Elena Sebokova,Karin Conde-Knape,Anish Konkar,Daniel J. Drucker,Vasily M. Gelfanov,Paul T. Pfluger,Timo D. Müller,Diego Perez-Tilve,Richard D. DiMarchi,Matthias H. Tschöp +28 more
TL;DR: It is demonstrated that these individual constituent activities harmonize to govern the overall metabolic efficacy, which predominantly results from synergistic glucagon action to increase energy expenditure, GLP-1 action to reduce caloric intake and improve glucose control, and GIP action to potentiate the incretin effect and buffer against the diabetogenic effect of inherent glucagon activity.
Journal ArticleDOI
Pancreatic acinar cells produce, release, and respond to tumor necrosis factor-alpha : role in regulating cell death and pancreatitis
Anna S. Gukovskaya,Ilya Gukovsky,V. Zaninovic,M Song,Darleen A. Sandoval,S Gukovsky,Stephen J. Pandol +6 more
TL;DR: The results indicate that pancreatic acinar cells produce, release, and respond to TNFalpha, a cytokine that regulates apoptosis in both isolated pancreas and experimental pancreatitis.
Journal ArticleDOI
Physiology of Proglucagon Peptides: Role of Glucagon and GLP-1 in Health and Disease
TL;DR: The physiological functions of both glucagon and GLP-1 are discussed by comparing and contrasting how these peptides function, variably in concert and opposition, to regulate glucose and energy homeostasis.