David B. Neau

TL;DR: A diffraction data publication and dissemination system, Structural Biology Data Grid (SBDG), to preserve primary experimental data sets that support scientific publications and demonstrates that the information archived by SBDG is sufficient to reprocess data to statistics that meet or exceed the quality of the original published structures.

TL;DR: It is demonstrated that ortho-chlorinated PCB metabolites strongly inhibit DHBD, promote its suicide inactivation and interfere with the degradation of other compounds, which have important implications for bioremediation strategies.

TL;DR: A small molecular inhibitor, N4A, was identified as an initial lead compound for PFKFB3 inhibitor with therapeutic potential and determined the crystal structure of the PFK FB3•N4A complex to 2.4 Å resolution and attained the more potent YN1.

TL;DR: Five SBiX–S100B complexes were identified and crystallographic structures confirmed their covalent binding to Cys84 near site 2 and thus present straightforward chemical biology strategies for bridging sites 1 and 3.

TL;DR: It is shown for both species that mutations at the C-terminal end of this epitope dramatically improve presentation to these T cells, suggesting that pancreas-specific posttranslational modifications of this peptide may play a role in the induction of diabetes and explain how the pathogenic T cells escape deletion in the thymus.