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David Communi
Researcher at Université libre de Bruxelles
Publications - 74
Citations - 6442
David Communi is an academic researcher from Université libre de Bruxelles. The author has contributed to research in topics: Chemerin & Ligand (biochemistry). The author has an hindex of 25, co-authored 69 publications receiving 5988 citations. Previous affiliations of David Communi include Free University of Brussels.
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The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.
Masato Kotani,Michel Detheux,Ann Vandenbogaerde,David Communi,Jean-Marie Vanderwinden,Emmanuel Le Poul,Stéphane Brézillon,Richard Tyldesley,Nathalie Suarez-Huerta,Fabrice Vandeput,Cédric Blanpain,Serge N. Schiffmann,Gilbert Vassart,Marc Parmentier +13 more
TL;DR: Stimulation of oxytocin secretion after kisspeptin administration to rats confirmed this hypothesis that human GPR54 was highly expressed in placenta, pituitary, pancreas, and spinal cord, suggesting a role in the regulation of endocrine function.
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Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids.
Valérie Wittamer,Jean-Denis Franssen,Marisa Vulcano,Jean François Mirjolet,Emmanuel Le Poul,Isabelle Migeotte,Stéphane Brézillon,Richard Tyldesley,Cédric Blanpain,Michel Detheux,Alberto Mantovani,Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Gilbert Vassart,Marc Parmentier,David Communi +16 more
TL;DR: Chemerin appears as a potent chemoattractant protein of a novel class, which requires proteolytic activation and is specific for APCs, and was shown to promote calcium mobilization and chemotaxis of immature DCs and macrophages in a ChemR23-dependent manner.
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Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1
Monica Autiero,Johannes Waltenberger,Didier Communi,Andrea Kranz,Lieve Moons,Diether Lambrechts,Jens Kroll,Stéphane Plaisance,Maria De Mol,Françoise Bono,Stefanie Kliche,Guido Fellbrich,Kurt Ballmer-Hofer,Domenico Maglione,Ulrike Mayr-Beyrle,Mieke Dewerchin,Saskia Dombrowski,Danica Stanimirovic,Paul Van Hummelen,Christoph Dehio,Daniel J. Hicklin,Graziella Persico,Jean-Marc Herbert,David Communi,Masabumi Shibuya,Desire Collen,Edward M. Conway,Peter Carmeliet +27 more
TL;DR: It is reported that placental growth factor (PGF) regulates inter- and intramolecular cross talk between the VEGF RTKs Flt1 and Flk1, which is likely to have therapeutic implications, as treatment with VegF/PGF heterodimer or a combination of VEGf plus PGF increased ischemic myocardial angiogenesis in a mouse model that was refractory to V EGF alone.
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Formyl peptide receptors: a promiscuous subfamily of G protein-coupled receptors controlling immune responses.
TL;DR: The physiological role of the FPR family is still incompletely understood, due in part to the large variety of ligands, the redundancy with other chemoattractant agents, and the lack of clear orthologs between human and mouse receptors.
Journal ArticleDOI
The role of chemerin in the colocalization of NK and dendritic cell subsets into inflamed tissues.
Silvia Parolini,Amerigo Santoro,Emanuela Marcenaro,Walter Luini,Luisa Massardi,Fabio Facchetti,David Communi,Marc Parmentier,Alessandra Majorana,Marina Sironi,Giovanna Tabellini,Alessandro Moretta,Silvano Sozzani +12 more
TL;DR: A role for the ChemR23/chemerin axis in the recruitment of blood NK cells is proposed and chemerin is strongly implicate as a key factor for the colocalization of NK cells and DC subsets in pathologic peripheral tissues.