Doreen te Raa

TL;DR: In this paper, the authors describe a 34-year old, pregnant female, who presented at 25 weeks of gestation with an acute collapse with reduced consciousness and shortness of breath caused by massive pulmonary embolism.

TL;DR: It is shown here that CLL-derived CMV-specific CD8(+) T cells display lower expression of exhaustion markers and are functionally intact, indicating that the changes in the T-cell compartment in CLL may be more heterogeneous than presently assumed.

TL;DR: In this paper, the authors investigated the impact of CLL-directed treatments on the course of Coronavirus disease 2019 (COVID-19) and found that patients with chronic lymphocytic leukemia (CLL) may be more susceptible to the disease due to age, disease, and treatment-related immunosuppression.

TL;DR: A next‐generation sequencing platform is developed to determine the genetic profile, intratumoural heterogeneity, and clonal structure of two independent CLL cohorts and finds evidence for subclonal mutations in 67·5% of CLL cases with mutations of cancer consensus genes.

TL;DR: The data extend earlier findings that specific genomic alterations and diversity of subclones are associated with disease progression and persistence of disease in CLL and identify novel recurrently mutated genes and associated outcomes.