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Erik C. B. Johnson
Researcher at Johns Hopkins University Applied Physics Laboratory
Publications - 89
Citations - 2452
Erik C. B. Johnson is an academic researcher from Johns Hopkins University Applied Physics Laboratory. The author has contributed to research in topics: Computer science & Medicine. The author has an hindex of 18, co-authored 62 publications receiving 1665 citations. Previous affiliations of Erik C. B. Johnson include Emory University & University of Illinois at Urbana–Champaign.
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Journal ArticleDOI
Insights into the mechanism and catalysis of the native chemical ligation reaction.
TL;DR: The most common thiol catalysts used to date have been either a mixture of thiophenol/benzyl mercaptan, or the alkanethiol MESNA.
Journal ArticleDOI
Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation
Erik C. B. Johnson,Eric B. Dammer,Duc M. Duong,Lingyan Ping,Maotian Zhou,Luming Yin,Lenora Higginbotham,Andrew Guajardo,Bartholomew White,Juan C. Troncoso,Madhav Thambisetty,Thomas J. Montine,Edward B. Lee,John Q. Trojanowski,Thomas G. Beach,Eric M. Reiman,Vahram Haroutunian,Vahram Haroutunian,Minghui Wang,Eric E. Schadt,Bin Zhang,Dennis W. Dickson,Nilufer Ertekin-Taner,Todd E. Golde,Vladislav A. Petyuk,Philip L. De Jager,David A. Bennett,Thomas S. Wingo,Srikant Rangaraju,Ihab Hajjar,Joshua M. Shulman,James J. Lah,Allan I. Levey,Nicholas T. Seyfried +33 more
TL;DR: Large-scale, comprehensive proteomic profiling of Alzheimer’s disease brain and cerebrospinal fluid reveals disease-associated protein coexpression modules and highlights the importance of glia and energy metabolism in disease pathogenesis.
Journal ArticleDOI
Life Extension Factor Klotho Prevents Mortality and Enhances Cognition in hAPP Transgenic Mice
Dena B. Dubal,Lei Zhu,Pascal E. Sanchez,Kurtresha Worden,Lauren Broestl,Erik C. B. Johnson,Kaitlyn Ho,Gui Qiu Yu,Daniel Kim,Alexander Betourne,Makoto Kuro-o,Eliezer Masliah,Carmela R. Abraham,Lennart Mucke +13 more
TL;DR: It is shown that elevating klotho expression decreases premature mortality and network dysfunction in human amyloid precursor protein (hAPP) transgenic mice, which simulate key aspects of AD.
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Deep proteomic network analysis of Alzheimer’s disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease
Erik C. B. Johnson,Eric B. Dammer,Duc M. Duong,Luming Yin,Madhav Thambisetty,Juan C. Troncoso,James J. Lah,Allan I. Levey,Nicholas T. Seyfried +8 more
TL;DR: A new proteomic systems-level analysis of AD brain based on 6,533 proteins measured across AD, AsymAD, and controls using an analysis pipeline consisting of isobaric tandem mass tag (TMT) mass spectrometry and offline prefractionation is reported.
Journal ArticleDOI
Integrated Proteomics Reveals Brain-Based Cerebrospinal Fluid Biomarkers in Asymptomatic and Symptomatic Alzheimer’s Disease
Lenora Higginbotham,Lingyan Ping,Eric B. Dammer,Duc M. Duong,Maotian Zhou,Marla Gearing,Cheyenne Hurst,Jonathan D. Glass,Stewart A. Factor,Erik C. B. Johnson,Ihab Hajjar,James J. Lah,Allan I. Levey,Nicholas T. Seyfried +13 more
TL;DR: Results are a promising step toward a network-based biomarker tool for AD clinical applications and identify cerebrospinal fluid biomarkers representing a wide spectrum of AD pathophysiology.