F
Felix T. Wieland
Researcher at Heidelberg University
Publications - 158
Citations - 22192
Felix T. Wieland is an academic researcher from Heidelberg University. The author has contributed to research in topics: COPI & Golgi apparatus. The author has an hindex of 71, co-authored 158 publications receiving 20604 citations. Previous affiliations of Felix T. Wieland include Stanford University.
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Journal ArticleDOI
Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes
Katarina Trajkovic,Chieh Hsu,Salvatore Chiantia,Lawrence Rajendran,Dirk Wenzel,Felix T. Wieland,Petra Schwille,Britta Brügger,Mikael Simons +8 more
TL;DR: It is found that cargo is segregated into distinct subdomains on the endosomal membrane and that the transfer of exosome-associated domains into the lumen of theendosome did not depend on the function of the ESCRT (endosomal sorting complex required for transport) machinery, but required the sphingolipid ceramide.
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Molecular Anatomy of a Trafficking Organelle
Shigeo Takamori,Matthew Holt,Katinka Stenius,Edward A. Lemke,Mads Grønborg,Dietmar Riedel,Henning Urlaub,Stephan Schenck,Britta Brügger,Philippe Ringler,Shirley A. Müller,Burkhard Rammner,Frauke Gräter,Jochen S. Hub,Bert L. de Groot,Gottfried Mieskes,Yoshinori Moriyama,Jürgen Klingauf,Helmut Grubmüller,John E. Heuser,Felix T. Wieland,Reinhard Jahn +21 more
TL;DR: A model has been constructed that integrates all quantitative data and includes structural models of abundant proteins and, with the exception of the V-ATPase, contains numerous copies of proteins essential for membrane traffic and neurotransmitter uptake.
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Protein Sorting by Transport Vesicles
TL;DR: Eukaryotic life depends on the spatial and temporal organization of cellular membrane systems and general principles that underlie a broad variety of physiological processes, including cell surface growth, the biogenesis of distinct intracellular organelles, endocytosis, and the controlled release of hormones and neurotransmitters.
Journal ArticleDOI
Vip21/caveolin is a cholesterol-binding protein
Masayuki Murata,Johan Peränen,Rupert Schreiner,Felix T. Wieland,Teymuras V. Kurzchalia,Kai Simons +5 more
TL;DR: Findings suggest that VIP21/caveolin, through its cholesterol-binding properties, serves a specific function in microdomain formation during membrane trafficking in caveolae and apical transport vesicles.
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Quantitative analysis of biological membrane lipids at the low picomole level by nano-electrospray ionization tandem mass spectrometry.
TL;DR: The optimized ionization and fragmentation conditions described together with the principle of internal standardization by nonnatural analogues allow the rapid and quantitative determination of membrane lipid compositions down to sample amounts of 1000 cells.