F
Fernando Pelaez
Researcher at Merck & Co.
Publications - 124
Citations - 7806
Fernando Pelaez is an academic researcher from Merck & Co.. The author has contributed to research in topics: Integrase & Farnesyl Protein Transferase. The author has an hindex of 41, co-authored 124 publications receiving 7350 citations. Previous affiliations of Fernando Pelaez include Autonomous University of Madrid.
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Journal ArticleDOI
Platensimycin is a selective FabF inhibitor with potent antibiotic properties
Jun Wang,Stephen M. Soisson,Katherine Young,Wesley L. Shoop,Wesley L. Shoop,Srinivas Kodali,Andrew Galgoci,Ronald E. Painter,Gopalakrishnan Parthasarathy,Yui S. Tang,Richard D. Cummings,Sookhee Ha,Karen Dorso,Mary Motyl,Hiranthi Jayasuriya,John G. Ondeyka,Kithsiri Herath,Chaowei Zhang,Lorraine D. Hernandez,John J. Allocco,Angela Basilio,José R. Tormo,Olga Genilloud,Francisca Vicente,Fernando Pelaez,Lawrence F. Colwell,Sang Ho Lee,B.F. Michael,Thomas J. Felcetto,Charles Gill,Lynn L. Silver,Lynn L. Silver,Jeffery D. Hermes,Ken Bartizal,John F. Barrett,Dennis M. Schmatz,Joseph W. Becker,Doris F. Cully,Sheo B. Singh +38 more
TL;DR: Platensimycin demonstrates strong, broad-spectrum Gram-positive antibacterial activity by selectively inhibiting cellular lipid biosynthesis through the selective targeting of β-ketoacyl-(acyl-carrier-protein (ACP) in the synthetic pathway of fatty acids.
Journal ArticleDOI
Discovery of a small molecule insulin mimetic with antidiabetic activity in mice.
Bei Zhang,Gino Salituro,Deborah Szalkowski,Zhihua Li,Yan Zhang,Inmaculada Royo,Dolores Vilella,Maria Teresa Diez,Fernando Pelaez,Caroline Ruby,Richard L. Kendall,Xianzhi Mao,Patrick R. Griffin,Jimmy R. Calaycay,Juleen R. Zierath,James V. Heck,Roy G. Smith,David E. Moller +17 more
TL;DR: The discovery of a nonpeptidyl fungal metabolite (L-783,281) that acted as an insulin mimetic in several biochemical and cellular assays demonstrates the feasibility of discovering novel insulin receptor activators that may lead to new therapies for diabetes.
Journal ArticleDOI
Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties.
Jun Wang,Srinivas Kodali,Sang Ho Lee,Andrew Galgoci,Ronald E. Painter,Karen Dorso,Fred Racine,Mary Motyl,Lorraine D. Hernandez,Elizabeth Tinney,Steven L. Colletti,Kithsiri Herath,Richard D. Cummings,Oscar Salazar,Ignacio González,Angela Basilio,Francisca Vicente,Olga Genilloud,Fernando Pelaez,Hiranthi Jayasuriya,Katherine Young,Doris F. Cully,Sheo B. Singh +22 more
TL;DR: Platencin shows potent in vivo efficacy without any observed toxicity, emphasizing the fact that more antibiotics with novel structures and new modes of action can be discovered by using this antisense differential sensitivity whole-cell screening paradigm.
Journal ArticleDOI
Screening of antimicrobial activities in red, green and brown macroalgae from Gran Canaria (Canary Islands, Spain).
Antonio González del Val,Gonzalo Platas,Angela Basilio,Angeles Cabello,Julian Gorrochategui,Inmaculada Suay,Francisca Vicente,Eduardo Portillo,Miguel Jiménez del Río,Guillermo García Reina,Fernando Pelaez +10 more
TL;DR: In this article, extracts from 44 species of seaweed from Gran Canaria (Canary Islands, Spain) were screened for the production of antibacterial and antifungal compounds against a panel of Gram-negative and Gram-positive bacteria, mycobacteria, yeasts and fungi.
Journal ArticleDOI
Discovery of Novel Antifungal (1,3)-β-d-Glucan Synthase Inhibitors
Janet C. Onishi,Maria S. Meinz,John R. Thompson,James E. Curotto,Sarah Dreikorn,Mark Rosenbach,Cameron M. Douglas,George K. Abruzzo,Amy M. Flattery,Leopold Kong,Angeles Cabello,Francisca Vicente,Fernando Pelaez,Maria Teresa Diez,Isabel Martin,Gerald F. Bills,Robert A. Giacobbe,Anne W. Dombrowski,Robert E. Schwartz,Sandra A. Morris,Guy H. Harris,A. Tsipouras,Kenneth E. Wilson,Myra B. Kurtz +23 more
TL;DR: Results of natural-product screening by a series of newly developed methods has led to the identification of four acidic terpenoid (1,3)-β-d-glucan synthase inhibitors, which have limited oral bioavailability and in vitro antifungal activity comparable to that of L-733560, a close analogue of MK-0991.