Flavio Mignone

TL;DR: Detailed polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development.

TL;DR: Gene expression is finely regulated at the post-transcriptional level through the regulation of stem-loop structures, upstream initiation codons and open reading frames, internal ribosome entry sites and various cis-acting elements that are bound by RNA-binding proteins.

TL;DR: The major structural and compositional features of eukaryotic mRNA untranslated regions are reviewed and some examples of bioinformatic analyses for their functional characterization are provided.

TL;DR: UTRdb, a specialized database of 5' and 3' untranslated sequences of eukaryotic mRNAs cleaned from redundancy is developed, enriched with specialized information not present in the primary databases including the presence of nucleotide sequence patterns already demonstrated by experimental analysis to have some functional role.

TL;DR: In the current update, the UTR entries have been organized in a gene-centric structure to better visualize and retrieve 5′ and 3′UTR variants generated by alternative initiation and termination of transcription and alternative splicing.