Frances Wu

TL;DR: In this paper, the authors identify two distinct homozygous LSS missense mutations (W581R and G588S) in two families with extensive congenital cataracts.

TL;DR: This study demonstrates the critical role of caspase-8 in IOP-induced cell death in rodent models of acute glaucoma and identifies a mechanism of retinal retinal ganglion cell death and provides a previously unidentified treatment strategy to preserve vision in acute glAUcoma.

TL;DR: This work designs a surgical method of cataract removal that preserves endogenous LECs and achieves functional lens regeneration in rabbits and macaques, as well as in human infants with cataracts, and provides a new paradigm for tissue regeneration using endogenous stem cells.

TL;DR: This is the first large-scale clinical study to systematically identify chromosomal aneuploidies based on cell-free fetal DNA using a benchtop semiconductor sequencing platform (SSP), which relies on the MPS platform but offers advantages over existing noninvasive screening techniques.

TL;DR: It is suggested that the preservation of visual acuity was likely achieved through host photoreceptor rescue, and hRPC transplantation into the subretinal space of RCS rats was well tolerated, with no adverse effects such as tumor formation noted at 12 weeks after treatment.