F
Frances Wu
Researcher at University of California, San Diego
Publications - 22
Citations - 1051
Frances Wu is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 9, co-authored 15 publications receiving 829 citations.
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Journal ArticleDOI
Lanosterol reverses protein aggregation in cataracts
Ling Zhao,Xiang-Jun Chen,Jie Zhu,Yi-Bo Xi,Xu Yang,Li-Dan Hu,Hong Ouyang,Sherrina Patel,Xin Jin,Danni Lin,Frances Wu,Ken Flagg,Huimin Cai,Gen Li,Guiqun Cao,Ying Lin,Daniel Chen,Cindy Wen,Christopher Chung,Yandong Wang,Austin Qiu,Emily Yeh,Wenqiu Wang,Xun Hu,Seanna Grob,Ruben Abagyan,Zhiguang Su,Harry C. Tjondro,Xi-Juan Zhao,Hongrong Luo,Rui Hou,J. Jefferson,P. Perry,Weiwei Gao,Igor Kozak,David B. Granet,Yingrui Li,Xiaodong Sun,Jun Wang,Liangfang Zhang,Yizhi Liu,Yong-Bin Yan,Kang Zhang +42 more
TL;DR: In this paper, the authors identify two distinct homozygous LSS missense mutations (W581R and G588S) in two families with extensive congenital cataracts.
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Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1β production in acute glaucoma
Wei Chi,Fei Li,Hongrui Chen,Yandong Wang,Yingting Zhu,Xuejiao Yang,Jie Zhu,Frances Wu,Hong Ouyang,Jian Ge,Robert N. Weinreb,Kang Zhang,Yehong Zhuo +12 more
TL;DR: This study demonstrates the critical role of caspase-8 in IOP-induced cell death in rodent models of acute glaucoma and identifies a mechanism of retinal retinal ganglion cell death and provides a previously unidentified treatment strategy to preserve vision in acute glAUcoma.
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Lens regeneration using endogenous stem cells with gain of visual function
Haotian Lin,Hong Ouyang,Jie Zhu,Shan Huang,Zhenzhen Liu,Shuyi Chen,Guiqun Cao,Gen Li,Robert A.J. Signer,Yanxin Xu,Christopher Chung,Ying Zhang,Danni Lin,Sherrina Patel,Frances Wu,Huimin Cai,Jiayi Hou,Cindy Wen,Maryam Jafari,Xialin Liu,Lixia Luo,Jin Zhu,Austin Qiu,Rui Hou,Baoxin Chen,Jiangna Chen,David B. Granet,Christopher W.D. Heichel,Fu Shang,Xuri Li,Michal Krawczyk,Dorota Skowronska-Krawczyk,Yujuan Wang,William Shi,Daniel Chen,Zheng Zhong,Zheng Zhong,Sheng Zhong,Liangfang Zhang,Shaochen Chen,Sean J. Morrison,Richard L. Maas,Kang Zhang,Yizhi Liu +43 more
TL;DR: This work designs a surgical method of cataract removal that preserves endogenous LECs and achieves functional lens regeneration in rabbits and macaques, as well as in human infants with cataracts, and provides a new paradigm for tissue regeneration using endogenous stem cells.
Journal ArticleDOI
Noninvasive prenatal diagnosis of common aneuploidies by semiconductor sequencing
Can Liao,Ai-hua Yin,Chun-fang Peng,Fang Fu,Jiexia Yang,Ru Li,Yangyi Chen,Dong-hong Luo,Yongling Zhang,Yan-Mei Ou,Jian Li,Jing Wu,Mingqin Mai,Rui Hou,Frances Wu,Hongrong Luo,Dong-Zhi Li,Hailiang Liu,Xiao-zhuang Zhang,Kang Zhang +19 more
TL;DR: This is the first large-scale clinical study to systematically identify chromosomal aneuploidies based on cell-free fetal DNA using a benchtop semiconductor sequencing platform (SSP), which relies on the MPS platform but offers advantages over existing noninvasive screening techniques.
Journal ArticleDOI
Human Retinal Progenitor Cell Transplantation Preserves Vision
Jing Luo,Jing Luo,Petr Baranov,Sherrina Patel,Hong Ouyang,John Quach,Frances Wu,Austin Qiu,Hongrong Luo,Caroline A Hicks,Jing Zeng,Jing Zeng,Jing Zhu,Jessica Lu,Nicole Sfeir,Cindy Wen,Meixia Zhang,Victoria Reade,Sara Patel,John Sinden,Xiaodong Sun,Peter X. Shaw,Michael J. Young,Kang Zhang +23 more
TL;DR: It is suggested that the preservation of visual acuity was likely achieved through host photoreceptor rescue, and hRPC transplantation into the subretinal space of RCS rats was well tolerated, with no adverse effects such as tumor formation noted at 12 weeks after treatment.