F
Francis G. Spinale
Researcher at University of South Carolina
Publications - 469
Citations - 24683
Francis G. Spinale is an academic researcher from University of South Carolina. The author has contributed to research in topics: Heart failure & Ventricular remodeling. The author has an hindex of 84, co-authored 451 publications receiving 23239 citations. Previous affiliations of Francis G. Spinale include Biogen Idec & Veterans Health Administration.
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Journal ArticleDOI
Myocardial Matrix Remodeling and the Matrix Metalloproteinases: Influence on Cardiac Form and Function
TL;DR: The purpose of this review is to examine and redefine the myocardial matrix as a critical and dynamic entity with respect to the remodeling process encountered with MI, hypertension, or cardiomyopathic disease, and to dispel the historical belief that the myCardial matrix is a passive structure.
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Pathophysiologically relevant concentrations of tumor necrosis factor- α promote progressive left ventricular dysfunction and remodeling in rats
Biykem Bozkurt,Scott B. Kribbs,Fred J. Clubb,Lloyd H. Michael,Vladimir V. Didenko,Peter J. Hornsby,Yukihiro Seta,Hakan Oral,Francis G. Spinale,Douglas L. Mann +9 more
TL;DR: These studies suggest that pathophysiologically relevant concentrations of TNF-alpha are sufficient to mimic certain aspects of the phenotype observed in experimental and clinical models of heart failure.
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Matrix Metalloproteinases: Regulation and Dysregulation in the Failing Heart
TL;DR: The elucidation of upstream signaling mechanisms that contribute to the selective induction of MMP species within the myocardium as well as strategies to normalize the balance between MMPs and TIMPs may yield some therapeutic strategies by which to control myocardial extracellular remodeling and thereby slow the progression of the CHF process.
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A Matrix Metalloproteinase Induction/Activation System Exists in the Human Left Ventricular Myocardium and Is Upregulated in Heart Failure
Francis G. Spinale,Mytsi L. Coker,Lena J. Heung,Brian R. Bond,Himali R. Gunasinghe,Takuma Etoh,Aron T. Goldberg,James L. Zellner,A. Jackson Crumbley +8 more
TL;DR: Increased LV myocardial MMP activity and selective upregulation of MMPs with nonischemic and ischemic forms of DCM occurred and a local MMP induction/activation system was identified in isolated normal human LV myocytes that was upregulated with DCM.
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Increased matrix metalloproteinase activity and selective upregulation in LV myocardium from patients with end-stage dilated cardiomyopathy.
Chadwick V. Thomas,Mytsi L. Coker,James L. Zellner,John R. Handy,A. Jackson Crumbley,Francis G. Spinale +5 more
TL;DR: Increased LV myocardial MMP activity and evidence for independent regulatory mechanisms of MMP and TIMP expression with DCM suggest that selective inhibition of M MP species within the LVMyocardium may provide a novel therapeutic target in patients withDCM.