F
Franz Oesch
Researcher at University of Mainz
Publications - 580
Citations - 22320
Franz Oesch is an academic researcher from University of Mainz. The author has contributed to research in topics: Epoxide hydrolase & Microsomal epoxide hydrolase. The author has an hindex of 76, co-authored 578 publications receiving 21684 citations. Previous affiliations of Franz Oesch include University of Basel & National Institutes of Health.
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Mammalian epoxide hydrases: inducible enzymes catalysing the inactivation of carcinogenic and cytotoxic metabolites derived from aromatic and olefinic compounds.
TL;DR: Whether a given aromatic or olefinic compound produces such an effect would depend on a variety of factors, such as the relative rate of formation and degradation of the intermediate oxirane, on its stability with respect to spontaneous isomerization to the corresponding phenol and on its chemical electrophilic reactivity.
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A radiometric assay for hepatic epoxide hydrase activity with [7-3H] styrene oxide☆
TL;DR: The simplicity of the present assay permits the use of epoxide hydrase a a marker enzyme for microsomal membranes in hepatic microsomes increases during maturation of rats and following pretreatment of rats with phenobarbital or 3-methylcholanthrene.
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Genotoxicity investigations on nanomaterials: Methods, preparation and characterization of test material, potential artifacts and limitations—Many questions, some answers
TL;DR: It is concluded that experiences with other, non-nano, substances taught us that mechanisms of genotoxic effects can be diverse and their elucidation can be demanding, while there often is an immediate need to assess the genotoxicity hazard.
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A multiplex polymerase chain reaction protocol for the simultaneous analysis of the glutathione S-transferase GSTM1 and GSTT1 polymorphisms.
Michael Arand,Roland Mühlbauer,Jan G. Hengstler,Elke Jäger,Jürgen Fuchs,Lars Winkler,Franz Oesch +6 more
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Immunoselection in vivo : independent loss of MHC class I and melanocyte differentiation antigen expression in metastatic melanoma
Elke Jäger,Mark Ringhoffer,Michael Altmannsberger,Michael Arand,Julia Karbach,Dirk Jäger,Franz Oesch,Alexander Knuth +7 more
TL;DR: The results suggest that strategies enhancing the expression of MHC class I and tumor‐associated antigens need to be considered in attempts at making vaccination more effective.