F
Frederick Klauschen
Researcher at Humboldt University of Berlin
Publications - 238
Citations - 17312
Frederick Klauschen is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 45, co-authored 170 publications receiving 12451 citations. Previous affiliations of Frederick Klauschen include Charité & National Institutes of Health.
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Journal ArticleDOI
Robust Anti-viral Immunity Requires Multiple Distinct T Cell-Dendritic Cell Interactions.
Sarah Eickhoff,Anna Brewitz,Michael Y. Gerner,Frederick Klauschen,Karl Komander,Hiroaki Hemmi,Natalio Garbi,Tsuneyasu Kaisho,Ronald N. Germain,Wolfgang Kastenmüller +9 more
TL;DR: The role of dendritic cell (DC) subsets in initial activation of the two T cell types and their co-operation is addressed, delineate the complex choreography of cellular interactions underlying effective cell-mediated anti-viral responses, and has implications for basic DC subset biology.
Journal ArticleDOI
Detection and Segmentation of Cell Nuclei in Virtual Microscopy Images: A Minimum-Model Approach
Stephan Wienert,Daniel Heim,Kai Saeger,Albrecht Stenzinger,Michael Beil,Peter Hufnagl,Manfred Dietel,Carsten Denkert,Frederick Klauschen +8 more
TL;DR: A novel contour-based “minimum-model” cell detection and segmentation approach that uses minimal a priori information and detects contours independent of their shape and allows for an accurate segmentation of a broad spectrum of normal and disease-related morphological features without the requirement of prior training.
Journal ArticleDOI
CD8+ T Cells Orchestrate pDC-XCR1+ Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming.
Anna Brewitz,Sarah Eickhoff,Sabrina Dähling,Thomas Quast,Sammy Bedoui,Richard A. Kroczek,Christian Kurts,Natalio Garbi,Winfried Barchet,Matteo Iannacone,Frederick Klauschen,Waldemar Kolanus,Tsuneyasu Kaisho,Marco Colonna,Ronald N. Germain,Wolfgang Kastenmüller +15 more
TL;DR: It is demonstrated that primed CD8+ T cells reorganize the intranodal dendritic cell network to optimize pDC and XCR1+ DC cooperativity and thereby enhance CD8- T cell immunity.
Journal ArticleDOI
Evaluation of automated brain MR image segmentation and volumetry methods.
Frederick Klauschen,Aaron L. Goldman,Vincent Barra,Andreas Meyer-Lindenberg,Arvid Lundervold +4 more
TL;DR: Since the discrepancies between results reach the same order of magnitude as volume changes observed in disease, these effects limit the usability of the segmentation methods for following volume changes in individual patients over time and should be taken into account during the planning and analysis of brain volume studies.
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Standardized evaluation of tumor-infiltrating lymphocytes in breast cancer: results of the ring studies of the international immuno-oncology biomarker working group.
Carsten Denkert,Stephan Wienert,Audrey Poterie,Sibylle Loibl,Jan Budczies,Sunil V. Badve,Zsuzsanna Bago-Horvath,Anita Bane,Shahinaz Bedri,Jane E. Brock,Ewa Chmielik,Matthias Christgen,Cecile Colpaert,Sandra Demaria,Gert Van den Eynden,Giuseppe Floris,Stephen B. Fox,Dongxia Gao,Barbara Ingold Heppner,S Rim Kim,Zuzana Kos,Hans Kreipe,Sunil R. Lakhani,Frédérique Penault-Llorca,Giancarlo Pruneri,Nina Radosevic-Robin,David L. Rimm,Stuart J. Schnitt,Bruno Valentin Sinn,Bruno Valentin Sinn,Peter Sinn,Nicolas Sirtaine,Sandra A O'Toole,Giuseppe Viale,Koen Van de Vijver,Roland de Wind,Gunter von Minckwitz,Frederick Klauschen,Michael Untch,Peter A. Fasching,Toralf Reimer,Karen Willard-Gallo,Stefan Michiels,Sherene Loi,Roberto Salgado +44 more
TL;DR: This large international standardization project shows that reproducible evaluation of TIL is feasible in breast cancer and opens the way for standardized reporting of tumor immunological parameters in clinical studies and diagnostic practice.