M
Michael Dudek
Researcher at Technische Universität München
Publications - 13
Citations - 824
Michael Dudek is an academic researcher from Technische Universität München. The author has contributed to research in topics: Immune system & Cytotoxic T cell. The author has an hindex of 5, co-authored 8 publications receiving 184 citations. Previous affiliations of Michael Dudek include University of Oxford.
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Journal ArticleDOI
NASH limits anti-tumour surveillance in immunotherapy-treated HCC
Dominik Pfister,Dominik Pfister,Nicolás Gonzalo Núñez,Roser Pinyol,Olivier Govaere,Matthias Pinter,Marta Szydlowska,Revant Gupta,Mengjie Qiu,Aleksandra Deczkowska,Assaf Weiner,Florian Müller,Ankit Sinha,Ankit Sinha,Ekaterina Friebel,Thomas Engleitner,Thomas Engleitner,Daniela Lenggenhager,Anja Moncsek,Danijela Heide,Kristin Stirm,Jan Kosla,Eleni Kotsiliti,Valentina Leone,Michael Dudek,Suhail Yousuf,Donato Inverso,Donato Inverso,Indrabahadur Singh,Ana Teijeiro,Florian Castet,Carla Montironi,Philipp K. Haber,Dina Tiniakos,Dina Tiniakos,Pierre Bedossa,Simon Cockell,Ramy Younes,Ramy Younes,Michele Vacca,Fabio Marra,Jörn M. Schattenberg,Michael Allison,Elisabetta Bugianesi,Vlad Ratziu,Tiziana Pressiani,Antonio D'Alessio,Nicola Personeni,Lorenza Rimassa,Ann K. Daly,Bernhard Scheiner,Katharina Pomej,Martha M. Kirstein,Arndt Vogel,Markus Peck-Radosavljevic,F. Hucke,Fabian Finkelmeier,Oliver Waidmann,Jörg Trojan,Kornelius Schulze,Henning Wege,Sandra Koch,Arndt Weinmann,Marco Bueter,Fabian Rössler,Alexander Siebenhüner,Sara De Dosso,Jan-Philipp Mallm,Viktor Umansky,Viktor Umansky,Manfred Jugold,Tom Luedde,Andrea Schietinger,Andrea Schietinger,Peter Schirmacher,Brinda Emu,Hellmut G. Augustin,Hellmut G. Augustin,Adrian T. Billeter,Beat P. Müller-Stich,Hiroto Kikuchi,Dan G. Duda,Fabian Kütting,Dirk Waldschmidt,Matthias P. Ebert,Nuh N. Rahbari,Henrik E. Mei,Axel Schulz,Marc Ringelhan,Nisar P. Malek,Stephan Spahn,Michael Bitzer,Marina Ruiz de Galarreta,Amaia Lujambio,Jean-François Dufour,Thomas U. Marron,Thomas U. Marron,Ahmed Kaseb,Masatoshi Kudo,Yi Hsiang Huang,Yi Hsiang Huang,Nabil Djouder,Katharina Wolter,Lars Zender,Lars Zender,Parice N. Marche,Parice N. Marche,Thomas Decaens,Thomas Decaens,David J. Pinato,Roland Rad,Roland Rad,Joachim C. Mertens,Achim Weber,Kristian Unger,Felix Meissner,Susanne Roth,Zuzana Macek Jilkova,Zuzana Macek Jilkova,Zuzana Macek Jilkova,Manfred Claassen,Quentin M. Anstee,Ido Amit,Percy A. Knolle,Burkhard Becher,Josep M. Llovet,Josep M. Llovet,Josep M. Llovet,Mathias Heikenwalder +128 more
TL;DR: The progressive accumulation of exhausted, unconventionally activated CD8+PD1+ T cells in NASH-affected livers provides a rationale for stratification of patients with HCC according to underlying aetiology in studies of immunotherapy as a primary or adjuvant treatment.
Journal ArticleDOI
Auto-aggressive CXCR6 + CD8 T cells cause liver immune pathology in NASH
Michael Dudek,Dominik Pfister,Sainitin Donakonda,Pamela Filpe,Annika Schneider,Melanie Laschinger,Daniel Hartmann,Norbert Hüser,Philippa Meiser,Felix Bayerl,Donato Inverso,Donato Inverso,Jennifer Wigger,Marcial Sebode,Rupert Öllinger,Roland Rad,Silke Hegenbarth,Martina Anton,Adrien Guillot,Andrew P. Bowman,Danijela Heide,Florian Müller,Pierluigi Ramadori,Valentina Leone,Cristina García-Cáceres,Tim Gruber,Gabriel Seifert,Agnieszka M. Kabat,Jan-Philipp Mallm,Simon Reider,Maria Effenberger,Susanne Roth,Adrian T. Billeter,Beat P. Müller-Stich,Edward J. Pearce,Friedrich Koch-Nolte,Rafael Käser,Herbert Tilg,Robert Thimme,Tobias Boettler,Frank Tacke,Jean-François Dufour,Dirk Haller,Peter J. Murray,Peter J. Murray,Ron M. A. Heeren,Dietmar Zehn,Jan P. Böttcher,Mathias Heikenwalder,Percy A. Knolle +49 more
TL;DR: In this paper, a preclinical mouse model that displays key features of human NASH (hereafter, NASH mice), was used to detect the hepatic accumulation of CD8 T cells with phenotypes that combined tissue residency (CXCR6) with effector (granzyme) and exhaustion (PD1) characteristics.
Journal ArticleDOI
Inhibition of LTβR signalling activates WNT-induced regeneration in lung.
Thomas M. Conlon,Gerrit John-Schuster,Danijela Heide,Dominik Pfister,Mareike Lehmann,Yan Hu,Zeynep Ertüz,Martin A. Lopez,Meshal Ansari,Maximilian Strunz,Christoph Mayr,Chiara Ciminieri,Rita Costa,Marlene Kohlhepp,Adrien Guillot,Gizem Gunes,Aicha Jeridi,Maja C. Funk,Giorgi Beroshvili,Sandra Prokosch,Jenny Hetzer,Stijn E. Verleden,Stijn E. Verleden,Hani N. Alsafadi,Michael Lindner,Gerald Burgstaller,Lore Becker,Martin Irmler,Michael Dudek,Jakob Janzen,Eric Goffin,Reinoud Gosens,Percy A. Knolle,Bernard Pirotte,Tobias Stoeger,Johannes Beckers,Darcy E. Wagner,Indrabahadur Singh,Fabian J. Theis,Martin Hrabé de Angelis,Tracy O'Connor,Frank Tacke,Michael Boutros,Emmanuel Dejardin,Oliver Eickelberg,Herbert B. Schiller,Melanie Königshoff,Mathias Heikenwalder,Ali Önder Yildirim +48 more
TL;DR: It is suggested that inhibition of LTβR signalling represents a viable therapeutic option that combines prevention of tertiary lymphoid structures 1 and inhibition of apoptosis with tissue-regenerative strategies.
Journal ArticleDOI
CD90(+) Stromal Cells are Non-Professional Innate Immune Effectors of the Human Colonic Mucosa.
Benjamin M. J. Owens,Tessa A. M. Steevels,Michael Dudek,David Walcott,Mei-Yi Sun,Alice Mayer,Philip Allan,Alison Simmons,Alison Simmons +8 more
TL;DR: CD90+ iSCs represent an abundant population of “non-professional” innate immune effector cells of the human colonic mucosa and likely play an important adjunctive role in host defense and immune regulation at this site.
Journal ArticleDOI
Liver sinusoidal endothelial cell cross-priming is supported by CD4 T cell-derived IL-2
Michaela Wittlich,Michael Dudek,Jan P. Böttcher,Oliver Schanz,Silke Hegenbarth,Tobias Bopp,Edgar Schmitt,Christian Kurts,Christoph Garbers,Stefan Rose John,Percy A. Knolle,Percy A. Knolle,Dirk Wohlleber +12 more
TL;DR: It is demonstrated that LSEC can serve as a platform to facilitate CD4-CD8 T cell crosstalk enhancing the immune function of LSECs to cross-prime CD8 T cells and enable CD4 T cell help for LSEC-priming of CD8T cells.