F
Fritz J. Sedlazeck
Researcher at Baylor College of Medicine
Publications - 171
Citations - 12273
Fritz J. Sedlazeck is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Genome & Biology. The author has an hindex of 35, co-authored 122 publications receiving 7133 citations. Previous affiliations of Fritz J. Sedlazeck include Medical University of Vienna & Cold Spring Harbor Laboratory.
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Posted ContentDOI
Phased Diploid Genome Assembly with Single Molecule Real-Time Sequencing
Chen-Shan Chin,Paul Peluso,Fritz J. Sedlazeck,Maria Nattestad,Gregory T. Concepcion,Alicia Clum,Christopher Dunn,Ronan C. O'Malley,Rosa Figueroa-Balderas,Abraham Morales-Cruz,Grant R. Cramer,Massimo Delledonne,Chongyuan Luo,Joseph R. Ecker,Dario Cantu,David R. Rank,Michael C. Schatz +16 more
TL;DR: The FALCON-based assemblies were substantially more contiguous and complete than alternate short or long-read approaches, and enabled the study of haplotype structures and heterozygosities between the homologous chromosomes, including identifying widespread heterozygous structural variations within the coding sequences.
Posted ContentDOI
Fast and accurate reference-guided scaffolding of draft genomes
Michael Alonge,Sebastian Soyk,Srividya Ramakrishnan,Xingang Wang,Sara Goodwin,Fritz J. Sedlazeck,Zachary B. Lippman,Zachary B. Lippman,Michael C. Schatz,Michael C. Schatz +9 more
TL;DR: RaGOO is presented, an open-source reference-guided contig ordering and orienting tool that leverages the speed and sensitivity of Minimap2 to accurately achieve chromosome-scale assemblies in just minutes and outperforms error-prone reference-free methods and enable rapid pan-genome analysis.
Journal ArticleDOI
Chromosomal-level assembly of the Asian seabass genome using long sequence reads and multi-layered scaffolding
Shubha Vij,Heiner Kuhl,Inna S. Kuznetsova,Inna S. Kuznetsova,Aleksey Komissarov,Andrey A. Yurchenko,Peter van Heusden,Siddharth Singh,Natascha May Thevasagayam,Sai Rama Sridatta Prakki,Kathiresan Purushothaman,Jolly M. Saju,Junhui Jiang,Stanley Kimbung Mbandi,Mario Jonas,Amy Hin Yan Tong,Sarah Mwangi,Doreen Lau,Si Yan Ngoh,Woei Chang Liew,Xueyan Shen,Lawrence S. Hon,James P Drake,Matthew Boitano,Richard Hall,Chen-Shan Chin,Ramkumar Lachumanan,Jonas Korlach,Vladimir A. Trifonov,Marsel R. Kabilov,Alexey E. Tupikin,Darrell Green,Simon Moxon,Tyler Garvin,Fritz J. Sedlazeck,Fritz J. Sedlazeck,Gregory Vurture,Gopikrishna Gopalapillai,Vinaya Kumar Katneni,Tansyn Noble,Vinod Scaria,Sridhar Sivasubbu,Dean R. Jerry,Stephen J. O'Brien,Stephen J. O'Brien,Michael C. Schatz,Michael C. Schatz,Tamas Dalmay,Stephen Turner,Si Lok,Alan Christoffels,László Orbán,László Orbán,László Orbán +53 more
TL;DR: The quality of the Asian seabass genome assembly far exceeds that of any other fish species, and will serve as a new standard for fish genomics.
Journal ArticleDOI
Complex rearrangements and oncogene amplifications revealed by long-read DNA and RNA sequencing of a breast cancer cell line
Maria Nattestad,Sara Goodwin,Karen Ng,Timour Baslan,Fritz J. Sedlazeck,Fritz J. Sedlazeck,Philipp Rescheneder,Tyler Garvin,Han Fang,James Gurtowski,Elizabeth Hutton,Elizabeth Tseng,Chen-Shan Chin,Timothy Beck,Yogi Sundaravadanam,Melissa Kramer,Eric Antoniou,John Douglas Mcpherson,James W. Hicks,W. Richard McCombie,Michael C. Schatz,Michael C. Schatz +21 more
TL;DR: One of the most detailed maps of structural variations in a cancer genome available is developed and a complex sequence of nested duplications and translocations is discovered around the important ERBB2 oncogene, suggesting a punctuated progression.
Journal ArticleDOI
Towards population-scale long-read sequencing.
TL;DR: Sedlazeck et al. as discussed by the authors survey recent developments in population-scale long-read sequencing, highlight potential challenges of a scaled-up approach and provide guidance regarding experimental design.