G
Geoffrey Prévot
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 17
Citations - 180
Geoffrey Prévot is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Medicine & Innate immune system. The author has an hindex of 4, co-authored 11 publications receiving 73 citations. Previous affiliations of Geoffrey Prévot include University of Bordeaux & French Institute of Health and Medical Research.
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Journal ArticleDOI
Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition.
Bram Priem,Mandy M. T. van Leent,Mandy M. T. van Leent,Abraham J. P. Teunissen,Alexandros Marios Sofias,Alexandros Marios Sofias,Vera P. Mourits,Lisa Willemsen,Emma D. Klein,Roderick S. Oosterwijk,Anu E. Meerwaldt,Anu E. Meerwaldt,Jazz Munitz,Geoffrey Prévot,Anna Vera D Verschuur,Sheqouia A. Nauta,Esther M. van Leeuwen,Elizabeth L. Fisher,Karen A.M. de Jong,Yiming Zhao,Yohana C. Toner,Georgios Soultanidis,Claudia Calcagno,Paul H. H. Bomans,Heiner Friedrich,Nico A. J. M. Sommerdijk,Thomas Reiner,Thomas Reiner,Raphaël Duivenvoorden,Raphaël Duivenvoorden,Eva Zupančič,Julie Di Martino,Ewelina Kluza,Mohammad Rashidian,Hidde L. Ploegh,Rick M. Dijkhuizen,Sjoerd Hak,Carlos Pérez-Medina,Carlos Pérez-Medina,Jose Javier Bravo-Cordero,Menno P.J. de Winther,Leo A. B. Joosten,Leo A. B. Joosten,Andrea van Elsas,Zahi A. Fayad,Alexander Rialdi,Denis Torre,Ernesto Guccione,Jordi Ochando,Jordi Ochando,Mihai G. Netea,Mihai G. Netea,Mihai G. Netea,Arjan W. Griffioen,Willem J. M. Mulder +54 more
TL;DR: It is shown that rationally designed nanobiologics can promote trained immunity and elicit a durable anti-tumor response either as a monotherapy or in combination with checkpoint inhibitor drugs.
Journal ArticleDOI
Harnessing Lysosomal pH through PLGA Nanoemulsion as a Treatment of Lysosomal-Related Neurodegenerative Diseases
Geoffrey Prévot,Federico N. Soria,Marie-Laure Thiolat,Marie-Laure Thiolat,Jonathan Daniel,Jean Baptiste Verlhac,Mireille Blanchard-Desce,Erwan Bezard,Erwan Bezard,Philippe Barthélémy,Sylvie Crauste-Manciet,Benjamin Dehay,Benjamin Dehay +12 more
TL;DR: It is demonstrated that acidic oil-in-water nanoemulsions loaded with poly(dl-lactide- co-glycolide) (PLGA) are able to rescue impaired lysosomal pH in genetic cellular models of Parkinson's disease.
Journal ArticleDOI
A modular approach toward producing nanotherapeutics targeting the innate immune system.
Mandy M. T. van Leent,Mandy M. T. van Leent,Anu E. Meerwaldt,Anu E. Meerwaldt,Alexandre Berchouchi,Yohana C. Toner,Marianne E. Burnett,Emma D. Klein,Anna Vera D Verschuur,Sheqouia A. Nauta,Jazz Munitz,Geoffrey Prévot,Esther M. van Leeuwen,Farideh Ordikhani,Vera P. Mourits,Claudia Calcagno,Philip M. Robson,George Soultanidis,Thomas Reiner,Thomas Reiner,Rick R. M. Joosten,Heiner Friedrich,Joren C. Madsen,Ewelina Kluza,Roy van der Meel,Leo A. B. Joosten,Mihai G. Netea,Mihai G. Netea,Jordi Ochando,Zahi A. Fayad,Carlos Perez-Medina,Willem J. M. Mulder,Willem J. M. Mulder,Abraham J. P. Teunissen +33 more
TL;DR: In this article, a short regimen of intravenously administered rapamycin-loaded nanobiologics (mTORi-NBs) significantly prolonged allograft survival in a heart transplantation mouse model.
Journal ArticleDOI
Iron oxide core oil-in-water nanoemulsion as tracer for atherosclerosis MPI and MRI imaging.
Geoffrey Prévot,Tina Kauss,Cyril Lorenzato,Alexandra Gaubert,Mélusine Larivière,Julie Baillet,Jeanny Laroche-Traineau,Marie Josée Jacobin-Valat,Laurent Adumeau,Stéphane Mornet,Philippe Barthélémy,Martine Duonor-Cérutti,Gisèle Clofent-Sanchez,Sylvie Crauste-Manciet +13 more
TL;DR: Preliminary results support that magnetic oil-in-water nanoemulsion platform could selectively image atherosclerosis and showed reasonable MRI/MPS signals and a significant labelling of the atheroma plaque.
Journal ArticleDOI
Acidic nanoparticles protect against α‐synuclein‐induced neurodegeneration through the restoration of lysosomal function
Marie-Laure Arotcarena,Federico N. Soria,Anthony Cunha,Evelyne Doudnikoff,Geoffrey Prévot,Jonathan Daniel,Mireille Blanchard-Desce,Philippe Barthélémy,Erwan Bezard,Sylvie Crauste-Manciet,Benjamin Dehay +10 more
TL;DR: It is demonstrated in vivo that aNPs protect nigral dopaminergic neurons from cell death, ameliorate α‐synuclein pathology, and restore lysosomal function in mice injected with PD patient‐derived Lewy body extracts carrying toxic α‐ synuclein aggregates.