L
Lisa Willemsen
Researcher at University of Amsterdam
Publications - 14
Citations - 448
Lisa Willemsen is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Macrophage & Medicine. The author has an hindex of 5, co-authored 8 publications receiving 161 citations.
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Journal ArticleDOI
High titers and low fucosylation of early human anti-SARS-CoV-2 IgG promote inflammation by alveolar macrophages.
Willianne Hoepel,Hung-Jen Chen,Chiara Elisabeth Geyer,Sona Allahverdiyeva,Xue D. Manz,Steven W. de Taeye,Jurjan Aman,Lynn Mes,Maurice Steenhuis,Guillermo R. Griffith,Peter I. Bonta,Philip J. M. Brouwer,Tom G. Caniels,Karlijn van der Straten,Korneliusz Golebski,René E. Jonkers,Mads Delbo Larsen,Federica Linty,Jan Nouta,Cindy P. A. A. van Roomen,Frank E.H.P. van Baarle,Cornelis M. van Drunen,Gertjan Wolbink,Alexander P.J. Vlaar,Godelieve J. de Bree,Rogier W. Sanders,Rogier W. Sanders,Lisa Willemsen,Annette E. Neele,Diederik van de Beek,Theo Rispens,Manfred Wuhrer,Harm Jan Bogaard,Marit J. van Gils,Gestur Vidarsson,Menno P.J. de Winther,Jeroen den Dunnen +36 more
TL;DR: In this paper, the authors show that early-phase severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) spike protein-specific immunoglobulin G (IgG) in serum of critically ill COVID-19 patients induces excessive inflammatory responses by human alveolar macrophages.
Journal ArticleDOI
Macrophage subsets in atherosclerosis as defined by single-cell technologies.
TL;DR: Three main macrophage subsets are described: resident‐like, pro‐inflammatory and anti‐inflammatory foamy TREM2hi macrophages, which are found in both mouse and human atherosclerotic plaques, andMacrophage subset‐specific markers and functions are discussed.
Journal ArticleDOI
Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition.
Bram Priem,Mandy M. T. van Leent,Mandy M. T. van Leent,Abraham J. P. Teunissen,Alexandros Marios Sofias,Alexandros Marios Sofias,Vera P. Mourits,Lisa Willemsen,Emma D. Klein,Roderick S. Oosterwijk,Anu E. Meerwaldt,Anu E. Meerwaldt,Jazz Munitz,Geoffrey Prévot,Anna Vera D Verschuur,Sheqouia A. Nauta,Esther M. van Leeuwen,Elizabeth L. Fisher,Karen A.M. de Jong,Yiming Zhao,Yohana C. Toner,Georgios Soultanidis,Claudia Calcagno,Paul H. H. Bomans,Heiner Friedrich,Nico A. J. M. Sommerdijk,Thomas Reiner,Thomas Reiner,Raphaël Duivenvoorden,Raphaël Duivenvoorden,Eva Zupančič,Julie Di Martino,Ewelina Kluza,Mohammad Rashidian,Hidde L. Ploegh,Rick M. Dijkhuizen,Sjoerd Hak,Carlos Pérez-Medina,Carlos Pérez-Medina,Jose Javier Bravo-Cordero,Menno P.J. de Winther,Leo A. B. Joosten,Leo A. B. Joosten,Andrea van Elsas,Zahi A. Fayad,Alexander Rialdi,Denis Torre,Ernesto Guccione,Jordi Ochando,Jordi Ochando,Mihai G. Netea,Mihai G. Netea,Mihai G. Netea,Arjan W. Griffioen,Willem J. M. Mulder +54 more
TL;DR: It is shown that rationally designed nanobiologics can promote trained immunity and elicit a durable anti-tumor response either as a monotherapy or in combination with checkpoint inhibitor drugs.
Posted ContentDOI
Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients promotes macrophage hyper-inflammatory responses
Willianne Hoepel,Hung-Jen Chen,Sona Allahverdiyeva,Xue D. Manz,Jurjan Aman,Peter I. Bonta,Philip J. M. Brouwer,Steven W. de Taeye,Tom G. Caniels,Karlijn van der Straten,Korneliusz Golebski,Guillermo R. Griffith,René E. Jonkers,Mads Delbo Larsen,Federica Linty,Anette Neele,Jan Nouta,Frank E.H.P. van Baarle,Cornelis M. van Drunen,Alexander P.J. Vlaar,Godelieve J. de Bree,Rogier W. Sanders,Lisa Willemsen,Manfred Wuhrer,Harm Jan Bogaard,Marit J. van Gils,Gestur Vidarsson,Menno P.J. de Winther,Jeroen den Dunnen +28 more
TL;DR: It is shown that anti-Spike IgG from serum of severely ill COVID-19 patients induces a hyper-inflammatory response by human macrophages, which subsequently breaks pulmonary endothelial barrier integrity and induces microvascular thrombosis.
Journal ArticleDOI
Impact of cholesterol on proinflammatory monocyte production by the bone marrow
Lotte C.A. Stiekema,Lisa Willemsen,Yannick Kaiser,Koen H.M. Prange,Nicholas J. Wareham,S. Matthijs Boekholdt,Carlijn Kuijk,Menno P.J. de Winther,Carlijn Voermans,Matthias Nahrendorf,Erik S.G. Stroes,Jeffrey Kroon +11 more
TL;DR: In this paper, the impact of LDL-C on monocyte production in the bone marrow (BM) compartment in human subjects was investigated, which revealed a potential contributory role of HSPC transcriptomic reprogramming to residual inflammatory risk in FH patients despite cholesterol-lowering therapy.