E
Emma D. Klein
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 11
Citations - 193
Emma D. Klein is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Medicine & Innate immune system. The author has an hindex of 4, co-authored 8 publications receiving 56 citations.
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Journal ArticleDOI
Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition.
Bram Priem,Mandy M. T. van Leent,Mandy M. T. van Leent,Abraham J. P. Teunissen,Alexandros Marios Sofias,Alexandros Marios Sofias,Vera P. Mourits,Lisa Willemsen,Emma D. Klein,Roderick S. Oosterwijk,Anu E. Meerwaldt,Anu E. Meerwaldt,Jazz Munitz,Geoffrey Prévot,Anna Vera D Verschuur,Sheqouia A. Nauta,Esther M. van Leeuwen,Elizabeth L. Fisher,Karen A.M. de Jong,Yiming Zhao,Yohana C. Toner,Georgios Soultanidis,Claudia Calcagno,Paul H. H. Bomans,Heiner Friedrich,Nico A. J. M. Sommerdijk,Thomas Reiner,Thomas Reiner,Raphaël Duivenvoorden,Raphaël Duivenvoorden,Eva Zupančič,Julie Di Martino,Ewelina Kluza,Mohammad Rashidian,Hidde L. Ploegh,Rick M. Dijkhuizen,Sjoerd Hak,Carlos Pérez-Medina,Carlos Pérez-Medina,Jose Javier Bravo-Cordero,Menno P.J. de Winther,Leo A. B. Joosten,Leo A. B. Joosten,Andrea van Elsas,Zahi A. Fayad,Alexander Rialdi,Denis Torre,Ernesto Guccione,Jordi Ochando,Jordi Ochando,Mihai G. Netea,Mihai G. Netea,Mihai G. Netea,Arjan W. Griffioen,Willem J. M. Mulder +54 more
TL;DR: It is shown that rationally designed nanobiologics can promote trained immunity and elicit a durable anti-tumor response either as a monotherapy or in combination with checkpoint inhibitor drugs.
Journal ArticleDOI
Probing myeloid cell dynamics in ischaemic heart disease by nanotracer hot-spot imaging
Max L. Senders,Max L. Senders,Anu E. Meerwaldt,Anu E. Meerwaldt,Mandy M. T. van Leent,Mandy M. T. van Leent,Brenda L. Sanchez-Gaytan,Brenda L. Sanchez-Gaytan,Jan C. van de Voort,Yohana C. Toner,Alexander Maier,Emma D. Klein,Nathaniel A. T. Sullivan,Alexandros Marios Sofias,Alexandros Marios Sofias,Hannah Groenen,Christopher Faries,Roderick S. Oosterwijk,Esther M. van Leeuwen,Francois Fay,Francois Fay,Elena Chepurko,Thomas Reiner,Raphaël Duivenvoorden,Raphaël Duivenvoorden,Lior Zangi,Rick M. Dijkhuizen,Sjoerd Hak,Filip K. Swirski,Matthias Nahrendorf,Carlos Pérez-Medina,Carlos Pérez-Medina,Abraham J. P. Teunissen,Zahi A. Fayad,Claudia Calcagno,Gustav J. Strijkers,Gustav J. Strijkers,Willem J. M. Mulder +37 more
TL;DR: A multimodal imaging approach using an innovative high-density lipoprotein-derived nanotracer with a perfluoro-crown ether payload enables myeloid cell dynamics to be studied in vivo in mouse models of atherosclerosis and myocardial infarction.
Journal ArticleDOI
Prosaposin mediates inflammation in atherosclerosis.
Mandy M. T. van Leent,Mandy M. T. van Leent,Thijs J. Beldman,Thijs J. Beldman,Yohana C. Toner,Marnix Lameijer,Marnix Lameijer,Nils Rother,Siroon Bekkering,Abraham J. P. Teunissen,Xianxiao Zhou,Roy van der Meel,Joost Malkus,Sheqouia A. Nauta,Emma D. Klein,Francois Fay,Francois Fay,Brenda L. Sanchez-Gaytan,Brenda L. Sanchez-Gaytan,Carlos Pérez-Medina,Carlos Pérez-Medina,Ewelina Kluza,Yu-Xiang Ye,Gregory R. Wojtkiewicz,Edward A. Fisher,Filip K. Swirski,Matthias Nahrendorf,Bin Zhang,Yang Li,Yang Li,Bowen Zhang,Leo A. B. Joosten,Gerard Pasterkamp,Arjan Boltjes,Zahi A. Fayad,Esther Lutgens,Esther Lutgens,Mihai G. Netea,Mihai G. Netea,Niels P. Riksen,Willem J. M. Mulder,Raphaël Duivenvoorden,Raphaël Duivenvoorden +42 more
TL;DR: In this article, the authors used myeloid cell-specific nanobiologics in apolipoprotein E-deficient (Apoe−/−) mice and found that targeting the mTOR and ribosomal protein S6 kinase-1 (S6K1) signaling pathways rapidly diminished plaque macrophages' inflammatory activity.
Journal ArticleDOI
Imaging Cardiovascular and Lung Macrophages With the Positron Emission Tomography Sensor 64Cu-Macrin in Mice, Rabbits, and Pigs.
Matthias Nahrendorf,Friedrich Felix Hoyer,Anu E. Meerwaldt,Anu E. Meerwaldt,Mandy M. T. van Leent,Mandy M. T. van Leent,Max L. Senders,Max L. Senders,Claudia Calcagno,Philip M. Robson,George Soultanidis,Carlos Pérez-Medina,Carlos Pérez-Medina,Abraham J. P. Teunissen,Yohana C. Toner,Kiyotake Ishikawa,Kenneth Fish,Ken Sakurai,Esther M. van Leeuwen,Esther M. van Leeuwen,Emma D. Klein,Alexandros Marios Sofias,Alexandros Marios Sofias,Thomas Reiner,Thomas Reiner,David Rohde,Aaron D. Aguirre,Gregory R. Wojtkiewicz,Stephen D. Schmidt,Yoshiko Iwamoto,David Izquierdo-Garcia,Peter Caravan,Filip K. Swirski,Ralph Weissleder,Willem J. M. Mulder +34 more
TL;DR: Results indicate 64Cu-Macrin could serve as a facile PET nanotracer to survey spatiotemporal macrophages dynamics during various physiological and pathological conditions and could stage inflammatory cardiovascular disease activity, assist disease management, and serve as an imaging biomarker for emerging macrophage-targeted therapeutics.
Journal ArticleDOI
A modular approach toward producing nanotherapeutics targeting the innate immune system.
Mandy M. T. van Leent,Mandy M. T. van Leent,Anu E. Meerwaldt,Anu E. Meerwaldt,Alexandre Berchouchi,Yohana C. Toner,Marianne E. Burnett,Emma D. Klein,Anna Vera D Verschuur,Sheqouia A. Nauta,Jazz Munitz,Geoffrey Prévot,Esther M. van Leeuwen,Farideh Ordikhani,Vera P. Mourits,Claudia Calcagno,Philip M. Robson,George Soultanidis,Thomas Reiner,Thomas Reiner,Rick R. M. Joosten,Heiner Friedrich,Joren C. Madsen,Ewelina Kluza,Roy van der Meel,Leo A. B. Joosten,Mihai G. Netea,Mihai G. Netea,Jordi Ochando,Zahi A. Fayad,Carlos Perez-Medina,Willem J. M. Mulder,Willem J. M. Mulder,Abraham J. P. Teunissen +33 more
TL;DR: In this article, a short regimen of intravenously administered rapamycin-loaded nanobiologics (mTORi-NBs) significantly prolonged allograft survival in a heart transplantation mouse model.