R
Roderick S. Oosterwijk
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 3
Citations - 118
Roderick S. Oosterwijk is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Ex vivo & Myeloid. The author has an hindex of 2, co-authored 2 publications receiving 39 citations.
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Journal ArticleDOI
Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition.
Bram Priem,Mandy M. T. van Leent,Mandy M. T. van Leent,Abraham J. P. Teunissen,Alexandros Marios Sofias,Alexandros Marios Sofias,Vera P. Mourits,Lisa Willemsen,Emma D. Klein,Roderick S. Oosterwijk,Anu E. Meerwaldt,Anu E. Meerwaldt,Jazz Munitz,Geoffrey Prévot,Anna Vera D Verschuur,Sheqouia A. Nauta,Esther M. van Leeuwen,Elizabeth L. Fisher,Karen A.M. de Jong,Yiming Zhao,Yohana C. Toner,Georgios Soultanidis,Claudia Calcagno,Paul H. H. Bomans,Heiner Friedrich,Nico A. J. M. Sommerdijk,Thomas Reiner,Thomas Reiner,Raphaël Duivenvoorden,Raphaël Duivenvoorden,Eva Zupančič,Julie Di Martino,Ewelina Kluza,Mohammad Rashidian,Hidde L. Ploegh,Rick M. Dijkhuizen,Sjoerd Hak,Carlos Pérez-Medina,Carlos Pérez-Medina,Jose Javier Bravo-Cordero,Menno P.J. de Winther,Leo A. B. Joosten,Leo A. B. Joosten,Andrea van Elsas,Zahi A. Fayad,Alexander Rialdi,Denis Torre,Ernesto Guccione,Jordi Ochando,Jordi Ochando,Mihai G. Netea,Mihai G. Netea,Mihai G. Netea,Arjan W. Griffioen,Willem J. M. Mulder +54 more
TL;DR: It is shown that rationally designed nanobiologics can promote trained immunity and elicit a durable anti-tumor response either as a monotherapy or in combination with checkpoint inhibitor drugs.
Journal ArticleDOI
Probing myeloid cell dynamics in ischaemic heart disease by nanotracer hot-spot imaging
Max L. Senders,Max L. Senders,Anu E. Meerwaldt,Anu E. Meerwaldt,Mandy M. T. van Leent,Mandy M. T. van Leent,Brenda L. Sanchez-Gaytan,Brenda L. Sanchez-Gaytan,Jan C. van de Voort,Yohana C. Toner,Alexander Maier,Emma D. Klein,Nathaniel A. T. Sullivan,Alexandros Marios Sofias,Alexandros Marios Sofias,Hannah Groenen,Christopher Faries,Roderick S. Oosterwijk,Esther M. van Leeuwen,Francois Fay,Francois Fay,Elena Chepurko,Thomas Reiner,Raphaël Duivenvoorden,Raphaël Duivenvoorden,Lior Zangi,Rick M. Dijkhuizen,Sjoerd Hak,Filip K. Swirski,Matthias Nahrendorf,Carlos Pérez-Medina,Carlos Pérez-Medina,Abraham J. P. Teunissen,Zahi A. Fayad,Claudia Calcagno,Gustav J. Strijkers,Gustav J. Strijkers,Willem J. M. Mulder +37 more
TL;DR: A multimodal imaging approach using an innovative high-density lipoprotein-derived nanotracer with a perfluoro-crown ether payload enables myeloid cell dynamics to be studied in vivo in mouse models of atherosclerosis and myocardial infarction.
Journal ArticleDOI
Resolving sepsis-induced immunoparalysis via trained immunity by targeting interleukin-4 to myeloid cells.
David P. Schrijver,Rutger J. Röring,Jeroen Deckers,Anne de Dreu,Yohana C. Toner,Geoffrey Prévot,Bram Priem,Jazz Munitz,Eveline G. Nugraha,Anthony Azzun,Tom Anbergen,Laszlo Groh,Anouk M. D. Becker,Carlos Pérez-Medina,Roderick S. Oosterwijk,Boris Novakovic,Simone J.C.F.M. Moorlag,A. A. I. Jansen,Peter Pickkers,Matthijs Kox,Thijs J. Beldman,Ewelina Kluza,Mandy M. T. van Leent,Abraham J. P. Teunissen,R. van der Meel,Zahi A. Fayad,Leo A. B. Joosten,Edward A. Fisher,Maarten Merkx,Mihai G. Netea,Willem J. M. Mulder +30 more
TL;DR: In this article , a fusion protein of apolipoprotein A1 (apoA1) and interleukin-4 (IL4) was developed to take advantage of this paradoxical IL4 feature in vivo, which integrates into a lipid nanoparticle.