G
Georgina S Humphreys
Researcher at University of Oxford
Publications - 26
Citations - 836
Georgina S Humphreys is an academic researcher from University of Oxford. The author has contributed to research in topics: Malaria & Plasmodium falciparum. The author has an hindex of 10, co-authored 19 publications receiving 597 citations. Previous affiliations of Georgina S Humphreys include University of London & University of Glasgow.
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Journal ArticleDOI
Amodiaquine and Artemether-Lumefantrine Select Distinct Alleles of the Plasmodium falciparum mdr1 Gene in Tanzanian Children Treated for Uncomplicated Malaria
Georgina S Humphreys,I. Merinopoulos,Jalal Uddin Ahmed,Christopher J. M. Whitty,Theonest K. Mutabingwa,Theonest K. Mutabingwa,Colin J. Sutherland,Rachel Hallett +7 more
TL;DR: It is concluded that AL and AQ exert opposite within-host selective effects on the Pfmdr1 gene of P. falciparum.
Journal ArticleDOI
Association of mutations in the Plasmodium falciparum Kelch13 gene (Pf3D7_1343700) with parasite clearance rates after artemisinin-based treatments : a WWARN individual patient data meta-analysis
Chanaki Amaratunga,Voahangy Andrianaranjaka,Elizabeth A. Ashley,Delia Bethell,Anders Björkman,Craig A. Bonnington,Roland A. Cooper,Mehul Dhorda,Arjen M. Dondorp,Annette Erhart,Rick M. Fairhurst,Abul Faiz,Caterina I. Fanello,Mark M. Fukuda,Philippe J Guerin,Rob Hooft van Huijsduijnen,Tran Tinh Hien,N. V. Hong,Ye Htut,Fang Huang,Georgina S Humphreys,Mallika Imwong,Kalynn Kennon,Pharath Lim,Khin Lin,Chanthap Lon,Andreas Mårtensson,Mayfong Mayxay,Olugbenga A. Mokuolu,Ulrika Morris,Billy Ngasala,Alfred Amambua-Ngwa,Harald Noedl,François Nosten,Marie A. Onyamboko,Aung Pyae Phyo,Christopher V. Plowe,Sasithon Pukrittayakamee,Milijaona Randrianarivelojosia,Philip J. Rosenthal,David L. Saunders,Carol Hopkins Sibley,Frank Smithuis,Michele D. Spring,Paul Sondo,Sokunthea Sreng,Peter Starzengruber,Kasia Stepniewska,Seila Suon,Shannon Takala-Harrison,Kamala Thriemer,Nguyen Thuy-Nhien,Kyaw Myo Tun,Nicholas J. White,Charles J. Woodrow +54 more
TL;DR: An individual patient data meta-analysis of the associations between parasite clearance half-life (PC1/2) and pfk13 genotype based on a large set of individual patient records from Asia and Africa demonstrates that 15 additional pfK13 alleles are associated strongly with the slow-clearing phenotype in Southeast Asia.
Journal ArticleDOI
The effect of chloroquine dose and primaquine on Plasmodium vivax recurrence: a WorldWide Antimalarial Resistance Network systematic review and individual patient pooled meta-analysis
Robert J. Commons,Robert J. Commons,Julie A. Simpson,Kamala Thriemer,Georgina S Humphreys,Tesfay Abreha,Sisay G Alemu,Sisay G Alemu,Arletta Añez,Nicholas M. Anstey,Ghulam Rahim Awab,Ghulam Rahim Awab,J. Kevin Baird,Bridget E. Barber,Isabelle Borghini-Fuhrer,Cindy S. Chu,Cindy S. Chu,Umberto D'Alessandro,Umberto D'Alessandro,Prabin Dahal,André Daher,André Daher,Peter J. de Vries,Annette Erhart,Annette Erhart,Annette Erhart,Margarete S M Gomes,Lilia Gonzalez-Ceron,Matthew J. Grigg,Aliehsan Heidari,Jimee Hwang,Jimee Hwang,Piet A. Kager,Tsige Ketema,Tsige Ketema,Wasif A. Khan,Marcus V. G. Lacerda,Toby Leslie,Benedikt Ley,Kartini Lidia,Wuelton Marcelo Monteiro,François Nosten,François Nosten,Dhelio Batista Pereira,Giao T Phan,Giao T Phan,Aung Pyae Phyo,Mark Rowland,Kavitha Saravu,Carol Hopkins Sibley,André Siqueira,André Siqueira,Kasia Stepniewska,Inge Sutanto,Walter R. J. Taylor,Guy E. Thwaites,Binh Q. Tran,Hien Tinh Tran,Neena Valecha,José Luiz Fernandes Vieira,Sonam Wangchuk,Timothy William,Charles J. Woodrow,Charles J. Woodrow,Lina Zuluaga-Idárraga,Philippe J Guerin,Nicholas J. White,Nicholas J. White,Ric N. Price,Ric N. Price +69 more
TL;DR: Radical cure with primaquine was highly effective in preventing early recurrence and may also improve blood schizontocidal efficacy against chloroquine-resistant P vivax malaria.
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Risk of Plasmodium vivax parasitaemia after Plasmodium falciparum infection: a systematic review and meta-analysis
Robert J. Commons,Julie A. Simpson,Kamala Thriemer,Mohammad Sharif Hossain,Nicholas M. Douglas,Nicholas M. Douglas,Georgina S Humphreys,Carol Hopkins Sibley,Carol Hopkins Sibley,Philippe J Guerin,Ric N. Price,Ric N. Price +11 more
TL;DR: A high risk of vivax parasitaemia is found after treatment of falciparum malaria, particularly in areas with short relapse periodicity and after rapidly eliminated treatment in co-endemic regions.
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The efficacy of dihydroartemisinin-piperaquine and artemether-lumefantrine with and without primaquine on Plasmodium vivax recurrence: A systematic review and individual patient data meta-analysis
Robert J. Commons,Julie A. Simpson,Kamala Thriemer,Tesfay Abreha,Ishag Adam,Nicholas M. Anstey,Ashenafi Assefa,Ghulam Rahim Awab,Ghulam Rahim Awab,J. Kevin Baird,Bridget E. Barber,Cindy S. Chu,Prabin Dahal,André Daher,André Daher,Timothy M. E. Davis,Arjen M. Dondorp,Matthew J. Grigg,Georgina S Humphreys,Jimee Hwang,Jimee Hwang,Harin Karunajeewa,Moses Laman,Moses Laman,Kartini Lidia,Brioni R. Moore,Brioni R. Moore,Brioni R. Moore,Ivo Mueller,Ivo Mueller,Ivo Mueller,François Nosten,Ayodhia Pitaloka Pasaribu,Ayodhia Pitaloka Pasaribu,Dhelio Batista Pereira,Aung Pyae Phyo,Jeanne Rini Poespoprodjo,Carol Hopkins Sibley,Kasia Stepniewska,Inge Sutanto,Guy E. Thwaites,Tran Tinh Hien,Nicholas J. White,Timothy William,Charles J. Woodrow,Philippe J Guerin,Ric N. Price +46 more
TL;DR: The risk of recurrent P. vivax recurrence at day 42 is observed to be significantly lower following treatment with DP compared with AL, reflecting the longer period of post-treatment prophylaxis; this risk was reduced substantially by coadministration with PQ.